Outputs (38)

Integrated approaches to testing and assessment for grouping nanomaterials following dermal exposure (2022)
Journal Article
Di Cristo, L., Janer, G., Dekkers, S., Boyles, M., Giusti, A., Keller, J. G., Wohlleben, W., Braakhuis, H., Ma-Hock, L., Oomen, A. G., Haase, A., Stone, V., Murphy, F., Johnston, H. J., & Sabella, S. (2022). Integrated approaches to testing and assessment for grouping nanomaterials following dermal exposure. Nanotoxicology, 16(3), 310-332. https://doi.org/10.1080/17435390.2022.2085207

Exposure to different nanoforms (NFs) via the dermal route is expected in occupational and consumer settings and thus it is important to assess their dermal toxicity and the contribution of dermal exposure to systemic bioavailability. We have formula... Read More about Integrated approaches to testing and assessment for grouping nanomaterials following dermal exposure.

Determining nanoform similarity via assessment of surface reactivity by abiotic and in vitro assays (2022)
Journal Article
Ag Seleci, D., Tsiliki, G., Werle, K., Elam, D. A., Okpowe, O., Seidel, K., Bi, X., Westerhoff, P., Innes, E., Boyles, M., Miller, M., Giusti, A., Murphy, F., Haase, A., Stone, V., & Wohlleben, W. (2022). Determining nanoform similarity via assessment of surface reactivity by abiotic and in vitro assays. NanoImpact, 26, Article 100390. https://doi.org/10.1016/j.impact.2022.100390

Grouping of substances is a method used to streamline hazard and risk assessment. Assessment of similarity provides the scientific evidence needed for formation of groups. This work reports on justification of grouping of nanoforms (NFs) via similari... Read More about Determining nanoform similarity via assessment of surface reactivity by abiotic and in vitro assays.

Bayesian based similarity assessment of nanomaterials to inform grouping (2022)
Journal Article
Tsiliki, G., Ag Seleci, D., Zabeo, A., Basei, G., Hristozov, D., Jeliazkova, N., Boyles, M., Murphy, F., Peijnenburg, W., Wohlleben, W., & Stone, V. (2022). Bayesian based similarity assessment of nanomaterials to inform grouping. NanoImpact, 25, Article 100389. https://doi.org/10.1016/j.impact.2022.100389

Nanoforms can be manufactured in plenty of variants by differing their physicochemical properties and toxicokinetic behaviour which can affect their hazard potential. To avoid testing of each single nanomaterial and nanoform variation and subsequentl... Read More about Bayesian based similarity assessment of nanomaterials to inform grouping.

Development of a standard operating procedure for the DCFH2-DA acellular assessment of reactive oxygen species produced by nanomaterials (2022)
Journal Article
Boyles, M., Murphy, F., Mueller, W., Wohlleben, W., Jacobsen, N. R., Braakhuis, H., Giusti, A., & Stone, V. (2022). Development of a standard operating procedure for the DCFH2-DA acellular assessment of reactive oxygen species produced by nanomaterials. Toxicology Mechanisms and Methods, 32(6), 439-452. https://doi.org/10.1080/15376516.2022.2029656

Improved strategies are required for testing nanomaterials (NMs) to make hazard and risk assessment more efficient and sustainable. Including reduced reliance on animal models, without decreasing the level of human health protection. Acellular detect... Read More about Development of a standard operating procedure for the DCFH2-DA acellular assessment of reactive oxygen species produced by nanomaterials.

Paradigms to assess the human health risks of nano- and microplastics (2021)
Journal Article
Noventa, S., Boyles, M. S. P., Seifert, A., Belluco, S., Jiménez, A. S., Johnston, H. J., Tran, L., Fernandes, T. F., Mughini-Gras, L., Orsini, M., Corami, F., Castro, K., Mutinelli, F., Boldrin, M., Puntes, V., Sotoudeh, M., Mascarello, G., Tiozzo, B., McLean, P., Ronchi, F., …Losasso, C. (2021). Paradigms to assess the human health risks of nano- and microplastics. Microplastics and Nanoplastics, 1, Article 9. https://doi.org/10.1186/s43591-021-00011-1

Human exposure to nano- and microplastics (NMPs) has raised major societal concerns, yet no framework to assess the risks of NMPs for human health exists. A substantial proportion of plastic produced worldwide is not properly disposed and persists in... Read More about Paradigms to assess the human health risks of nano- and microplastics.

Simulated biological fluids – a systematic review of their biological relevance and use in relation to inhalation toxicology of particles and fibres (2021)
Journal Article
Innes, E., Yiu, H. H. P., McLean, P., Brown, W., & Boyles, M. (2021). Simulated biological fluids – a systematic review of their biological relevance and use in relation to inhalation toxicology of particles and fibres. Critical Reviews in Toxicology, 51(3), 217-248. https://doi.org/10.1080/10408444.2021.1903386

The use of simulated biological fluids (SBFs) is a promising in vitro technique to better understand the release mechanisms and possible in vivo behaviour of materials, including fibres, metal-containing particles and nanomaterials. Applications of S... Read More about Simulated biological fluids – a systematic review of their biological relevance and use in relation to inhalation toxicology of particles and fibres.

A Method to Assess the Relevance of Nanomaterial Dissolution during Reactivity Testing (2020)
Journal Article
Peijnenburg, W. J. G. M., Ruggiero, E., Boyles, M., Murphy, F., Stone, V., Elam, D. A., Werle, K., & Wohlleben, W. (2020). A Method to Assess the Relevance of Nanomaterial Dissolution during Reactivity Testing. Materials, 13(10), Article 2235. https://doi.org/10.3390/ma13102235

The reactivity of particle surfaces can be used as a criterion to group nanoforms (NFs) based on similar potential hazard. Since NFs may partially or completely dissolve over the duration of the assays, with the ions themselves inducing a response, r... Read More about A Method to Assess the Relevance of Nanomaterial Dissolution during Reactivity Testing.

Assessment of the physicochemical properties of chrysotile-containing brake debris pertaining to toxicity (2019)
Journal Article
Boyles, M. S. P., Poland, C. A., Raftis, J., & Duffin, R. (2019). Assessment of the physicochemical properties of chrysotile-containing brake debris pertaining to toxicity. Inhalation Toxicology, 31(8), 325-342. https://doi.org/10.1080/08958378.2019.1683103

Grinding and drilling of chrysotile asbestos-containing brake pads during the 20thcentury led torelease of chrysotile, resulting in varying levels of workplace exposures of mechanics. Despite expo-sures, excess risk of mesothelioma remains in doubt.... Read More about Assessment of the physicochemical properties of chrysotile-containing brake debris pertaining to toxicity.

Assessing the bioactivity of crystalline silica in heated high-temperature insulation wools (2018)
Journal Article
Boyles, M. S. P., Brown, D., Knox, J., Horobin, M., Miller, M. R., Johnston, H. J., & Stone, V. (2018). Assessing the bioactivity of crystalline silica in heated high-temperature insulation wools. Inhalation Toxicology, 30(7-8), 255-272. https://doi.org/10.1080/08958378.2018.1513610

High-Temperature Insulation Wools (HTIW), such as alumino silicate wools (Refractory Ceramic Fibers) and Alkaline Earth Silicate wools, are used in high-temperature industries for thermal insulation. These materials have an amorphous glass-like struc... Read More about Assessing the bioactivity of crystalline silica in heated high-temperature insulation wools.

Releases from transparent blue automobile coatings containing nanoscale copper phthalocyanine and their effects on J774 A1 macrophages (2017)
Journal Article
Pang, C., Neubauer, N., Boyles, M., Brown, D., Kanase, N., Hristozov, D., Fernandes, T., Stone, V., Wohlleben, W., & Marcomini, A. (2017). Releases from transparent blue automobile coatings containing nanoscale copper phthalocyanine and their effects on J774 A1 macrophages. NanoImpact, 7, 75-83. https://doi.org/10.1016/j.impact.2017.06.002

Nanoscale copper phthalocyanine (n-CuPc) is a pigment widely used in paints to enhance automobile coatings and to make colors transparent and more appealing to users. Despite the benefits, n-CuPc can potentially be released into the environment and p... Read More about Releases from transparent blue automobile coatings containing nanoscale copper phthalocyanine and their effects on J774 A1 macrophages.