Outputs (68)

Quantifying the phenome-wide response to sex-specific selection in Drosophila melanogaster (2025)
Journal Article
Keaney, T. A., & Holman, L. (2025). Quantifying the phenome-wide response to sex-specific selection in Drosophila melanogaster. Evolution, 79(5), 765–778. https://doi.org/10.1093/evolut/qpaf024

In species with separate sexes, selection on males causes evolutionary change in female traits values (and vice versa) via genetic correlations, which has far-reaching consequences for adaptation. Here, we utilise a sex-specific form of Robertson’s S... Read More about Quantifying the phenome-wide response to sex-specific selection in Drosophila melanogaster.

From whole bodies to single cells: A guide to transcriptomic approaches for ecology and evolutionary biology (2024)
Journal Article
Hoedjes, K. M., Grath, S., Posnien, N., Ritchie, M. G., Schlötterer, C., Abbott, J. K., Almudi, I., Coronado‐Zamora, M., Durmaz Mitchell, E., Flatt, T., Fricke, C., Glaser‐Schmitt, A., González, J., Holman, L., Kankare, M., Lenhart, B., Orengo, D. J., Snook, R. R., Yılmaz, V. M., & Yusuf, L. (online). From whole bodies to single cells: A guide to transcriptomic approaches for ecology and evolutionary biology. Molecular Ecology, Article e17382. https://doi.org/10.1111/mec.17382

RNA sequencing (RNAseq) methodology has experienced a burst of technological developments in the last decade, which has opened up opportunities for studying the mechanisms of adaptation to environmental factors at both the organismal and cellular lev... Read More about From whole bodies to single cells: A guide to transcriptomic approaches for ecology and evolutionary biology.

Pleiotropic fitness effects across sexes and ages in the Drosophila genome and transcriptome (2023)
Journal Article
Wong, H. W. S., & Holman, L. (2023). Pleiotropic fitness effects across sexes and ages in the Drosophila genome and transcriptome. Evolution, 77(12), 2642–2655. https://doi.org/10.1093/evolut/qpad163

Selection varies between categories of individuals, with far-reaching ramifications: Sex-specific selection can impede or accelerate adaptation, and differences in selection between young and old individuals are ultimately responsible for senescence.... Read More about Pleiotropic fitness effects across sexes and ages in the Drosophila genome and transcriptome.

Polygenic signals of sex differences in selection in humans from the UK Biobank (2022)
Journal Article
Ruzicka, F., Holman, L., & Connallon, T. (2022). Polygenic signals of sex differences in selection in humans from the UK Biobank. PLOS Biology, 20(9), Article e3001768. https://doi.org/10.1371/journal.pbio.3001768

Sex differences in the fitness effects of genetic variants can influence the rate of adaptation and the maintenance of genetic variation. For example, “sexually antagonistic” (SA) variants, which are beneficial for one sex and harmful for the other,... Read More about Polygenic signals of sex differences in selection in humans from the UK Biobank.

Experimental sexual selection affects the evolution of physiological and life‐history traits (2022)
Journal Article
Garlovsky, M. D., Holman, L., Brooks, A. L., Novicic, Z. K., & Snook, R. R. (2022). Experimental sexual selection affects the evolution of physiological and life‐history traits. Journal of Evolutionary Biology, 35(5), 742-751. https://doi.org/10.1111/jeb.14003

Sexual selection and sexual conflict are expected to affect all aspects of the phenotype, not only traits that are directly involved in reproduction. Here, we show coordinated evolution of multiple physiological and life-history traits in response to... Read More about Experimental sexual selection affects the evolution of physiological and life‐history traits.

Social immunity in the honey bee: do immune-challenged workers enter enforced or self-imposed exile? (2022)
Journal Article
Conroy, T. E., & Holman, L. (2022). Social immunity in the honey bee: do immune-challenged workers enter enforced or self-imposed exile?. Behavioral Ecology and Sociobiology, 76(2), Article 32. https://doi.org/10.1007/s00265-022-03139-z

Animals living in large colonies are especially vulnerable to infectious pathogens and may therefore have evolved additional defences. Eusocial insects supplement their physiological immune systems with ‘social immunity’, a set of adaptations that im... Read More about Social immunity in the honey bee: do immune-challenged workers enter enforced or self-imposed exile?.

A comment on 'The adaptive value of gluttony: predators mediate the life history trade‐offs of satiation threshold' by Pruitt & Krauel (2010) (2021)
Journal Article
Postma, E., Gonzalez‐Voyer, A., & Holman, L. (2021). A comment on 'The adaptive value of gluttony: predators mediate the life history trade‐offs of satiation threshold' by Pruitt & Krauel (2010). Journal of Evolutionary Biology, 34(12), 1989-1993. https://doi.org/10.1111/jeb.13885

Inspection of the data that accompany Pruitt and Krauel's study of individual variation in satiation threshold and a comparison of these data with the Materials and Methods and Results sections of the paper have revealed a number of issues that cast... Read More about A comment on 'The adaptive value of gluttony: predators mediate the life history trade‐offs of satiation threshold' by Pruitt & Krauel (2010).

Sexual selection affects the evolution of physiological and life history traits (2021)
Preprint / Working Paper
Snook, R. R., Brooks, A. L., Holman, L., & Garlovsky, S. D. Sexual selection affects the evolution of physiological and life history traits

Sexual selection and sexual conflict are expected to affect all aspects of the phenotype, not only traits that are directly involved in reproduction. Here, we show coordinated evolution of multiple physiological and life history traits in response to... Read More about Sexual selection affects the evolution of physiological and life history traits.

Sexual selection can partly explain low frequencies of Segregation Distorter alleles (2021)
Journal Article
Keaney, T. A., Jones, T. M., & Holman, L. (2021). Sexual selection can partly explain low frequencies of Segregation Distorter alleles. Proceedings of the Royal Society B: Biological Sciences, 288(1959), https://doi.org/10.1098/rspb.2021.1190

The Segregation Distorter (SD) allele found in Drosophila melanogaster distorts Mendelian inheritance in heterozygous males by causing developmental failure of non-SD spermatids, such that greater than 90% of the surviving sperm carry SD. This within... Read More about Sexual selection can partly explain low frequencies of Segregation Distorter alleles.

Male‐biased sexual selection, but not sexual dichromatism, predicts speciation in birds (2021)
Journal Article
Cally, J. G., Stuart‐Fox, D., Holman, L., Dale, J., & Medina, I. (2021). Male‐biased sexual selection, but not sexual dichromatism, predicts speciation in birds. Evolution, 75(4), 931-944. https://doi.org/10.1111/evo.14183

Sexual selection is thought to shape phylogenetic diversity by affecting speciation or extinction rates. However, the net effect of sexual selection on diversification is hard to predict because many of the hypothesized effects on speciation or extin... Read More about Male‐biased sexual selection, but not sexual dichromatism, predicts speciation in birds.