Outputs (2)

The effects of PM10 particles and oxidative stress on macrophages and lung epithelial cells: modulating effects of calcium-signaling antagonists. (2007)
Journal Article
Brown, D. M., Hutchison, L., Donaldson, K., & Stone, V. (2007). The effects of PM10 particles and oxidative stress on macrophages and lung epithelial cells: modulating effects of calcium-signaling antagonists. American journal of physiology. Lung cellular and molecular physiology, 292, L1444-L1451. https://doi.org/10.1152/ajplung.00162.2006

We have previously examined the ability of air pollution particles (PM10) to promote release of the proinflammatory cytokine tumor necrosis factor- (TNF-) from human peripheral blood mononuclear cells and demonstrated a role for calcium as a signalin... Read More about The effects of PM10 particles and oxidative stress on macrophages and lung epithelial cells: modulating effects of calcium-signaling antagonists..

The effect of oxidative stress on macrophages and lung epithelial cells: The role of phosphodiesterases 1 and 4 (2007)
Journal Article
Brown, D. M., Hutchison, L., Donaldson, K., MacKenzie, S., Dick, C., & Stone, V. (2007). The effect of oxidative stress on macrophages and lung epithelial cells: The role of phosphodiesterases 1 and 4. Toxicology Letters, 168(1), 1-6. https://doi.org/10.1016/j.toxlet.2006.10.016

Reactive oxygen species (ROS) have been implicated in various pulmonary diseases by causing direct injury to lung epithelial cells. Signalling activity of cells through transcription factors such as nuclear factor kappa B (NF-κB) and AP-1 have been s... Read More about The effect of oxidative stress on macrophages and lung epithelial cells: The role of phosphodiesterases 1 and 4.