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Outputs (47)

Priorities to inform research on tire particles and their chemical leachates: A collective perspective (2024)
Journal Article
Obanya, H. E., Khan, F. R., Carrasco-Navarro, V., Rødland, E. S., Walker-Franklin, I., Thomas, J., Cooper, A., Molden, N., Amaeze, N. H., Patil, R. S., Kukkola, A., Michie, L., Green-Ojo, B., Rauert, C., Couceiro, F., Hutchison, G., Tang, J., Ugor, J., Lee, S., Hofmann, T., & Ford, A. T. (2024). Priorities to inform research on tire particles and their chemical leachates: A collective perspective. Environmental Research, 263(3), Article 120222. https://doi.org/10.1016/j.envres.2024.120222

Concerns over the ecological impacts of urban road runoff have increased, partly due to recent research into the harmful impacts of tire particles and their chemical leachates. This study aimed to help the community of researchers, regulators and pol... Read More about Priorities to inform research on tire particles and their chemical leachates: A collective perspective.

A Horizon Scan to Support Chemical Pollution–Related Policymaking for Sustainable and Climate‐Resilient Economies (2023)
Journal Article
Green, C., Bilyanska, A., Bradley, M., Dinsdale, J., Hutt, L., Backhaus, T., Boons, F., Bott, D., Collins, C., Cornell, S. E., Craig, M., Depledge, M., Diderich, B., Fuller, R., Galloway, T. S., Hutchison, G. R., Ingrey, N., Johnson, A. C., Kupka, R., Matthiessen, P., …Lynch, I. (2023). A Horizon Scan to Support Chemical Pollution–Related Policymaking for Sustainable and Climate‐Resilient Economies. Environmental Toxicology and Chemistry, 42(6), 1212-1228. https://doi.org/10.1002/etc.5620

While chemicals are vital to modern society through materials, agriculture, textiles, new technology, medicines, and consumer goods, their use is not without risks. Unfortunately, our resources seem inadequate to address the breadth of chemical chall... Read More about A Horizon Scan to Support Chemical Pollution–Related Policymaking for Sustainable and Climate‐Resilient Economies.

Pre-validation of a reporter gene assay for oxidative stress for the rapid screening of nanobiomaterials (2022)
Journal Article
Martin, S., de Haan, L., Miro Estruch, I., Eder, K. M., Marzi, A., Schnekenburger, J., Blosi, M., Costa, A., Antonello, G., Bergamaschi, E., Riganti, C., Beal, D., Carrière, M., Taché, O., Hutchison, G., Malone, E., Young, L., Campagnolo, L., La Civita, F., Pietroiusti, A., …Bouwmeester, H. (2022). Pre-validation of a reporter gene assay for oxidative stress for the rapid screening of nanobiomaterials. Frontiers in Toxicology, 4, Article 974429. https://doi.org/10.3389/ftox.2022.974429

Engineered nanomaterials have been found to induce oxidative stress. Cellular oxidative stress, in turn, can result in the induction of antioxidant and detoxification enzymes which are controlled by the nuclear erythroid 2-related factor 2 (NRF2) tra... Read More about Pre-validation of a reporter gene assay for oxidative stress for the rapid screening of nanobiomaterials.

Assessing the toxicity of engineered nanomaterials in the male reproductive system: Developing improved methods and strategies for hazard assessment (2022)
Presentation / Conference Contribution
Ross, B. L., Malone, E. M., Rae, M. T., Bouwmeester, H., van der Zande, M., & Hutchison, G. R. (2022, March). Assessing the toxicity of engineered nanomaterials in the male reproductive system: Developing improved methods and strategies for hazard assessment. Poster presented at Society of Toxicology 61st Annual Meeting, San Diego, California

Key actions for a sustainable chemicals policy (2020)
Journal Article
Collins, C., Depledge, M., Fraser, R., Johnson, A., Hutchison, G., Matthiessen, P., Murphy, R., Owens, S., & Sumpter, J. (2020). Key actions for a sustainable chemicals policy. Environment International, 137, Article 105463. https://doi.org/10.1016/j.envint.2020.105463

Chemicals policies have spawned a wide range of regulations aimed at limiting damage to the environment and human health. Most instruments are reactive and fragmented. We propose a simple underpinning philosophy, “Do no harm”, to ensure a more sustai... Read More about Key actions for a sustainable chemicals policy.

Silver nanoparticles promote the emergence of heterogeneic human neutrophil sub-populations (2018)
Journal Article
Kemp, S., Young, L., Ross, M., Prach, M., Hutchison, G. R., Malone, E., & Fraser, J. A. (2018). Silver nanoparticles promote the emergence of heterogeneic human neutrophil sub-populations. Scientific Reports, 8(1), Article 7506. https://doi.org/10.1038/s41598-018-25854-2

Neutrophil surveillance is central to nanoparticle clearance. Silver nanoparticles (AgNP) have numerous uses, however conflicting evidence exists as to their impact on neutrophils and whether they trigger damaging inflammation. Neutrophil’s importanc... Read More about Silver nanoparticles promote the emergence of heterogeneic human neutrophil sub-populations.

Investigating the molecular mechanisms driving neuroendocrine differentiation in androgen deprived prostate cancer cells (2016)
Presentation / Conference Contribution
Sutton, J., Hutchison, G., Fraser, J., & Poole, A. (2016, November). Investigating the molecular mechanisms driving neuroendocrine differentiation in androgen deprived prostate cancer cells. Presented at National Cancer Research Institute Conference, Liverpool, UK

Background: Neuroendocrine differentiation is commonplace in prostate tumors treated with androgen deprivation therapy and is associated with castrate-resistant disease progression and poor prognosis. The molecular mechanisms driving neuroendocrine d... Read More about Investigating the molecular mechanisms driving neuroendocrine differentiation in androgen deprived prostate cancer cells.