Outputs (18)

A 16-week progressive exercise training intervention in treatment-naïve chronic lymphocytic leukaemia: a randomised-controlled pilot study (2024)
Journal Article
Brown, F. F., Oliver, R., Eddy, R., Causer, A. J., Emery, A., Collier-Bain, H. D., Dutton, D., Crowe, J., Augustine, D., Graby, J., Rees, D., Rothschild-Rodriguez, D., Peacock, O. J., Moore, S., Murray, J., Turner, J. E., & Campbell, J. P. (2024). A 16-week progressive exercise training intervention in treatment-naïve chronic lymphocytic leukaemia: a randomised-controlled pilot study. Frontiers in Oncology, 14, Article 1472551. https://doi.org/10.3389/fonc.2024.1472551

Background: Chronic lymphocytic leukaemia (CLL) typically presents with asymptomatic, early-stage disease that is monitored until disease progression (‘treatment-naïve’ CLL). The objective of this pilot study was to assess the feasibility and prelimi... Read More about A 16-week progressive exercise training intervention in treatment-naïve chronic lymphocytic leukaemia: a randomised-controlled pilot study.

Downhill running does not alter blood C1q availability or complement-dependent cytotoxicity of therapeutic monoclonal antibodies against haematological cancer cell lines in vitro (2024)
Journal Article
Collier-Bain, H. D., Brown, F. F., Causer, A. J., Ross, L., Rothschild-Rodriguez, D., Browne, N., Eddy, R., Cleary, K. L., Gray, J. C., Cragg, M. S., Moore, S., Murray, J., Turner, J. E., & Campbell, J. P. (2024). Downhill running does not alter blood C1q availability or complement-dependent cytotoxicity of therapeutic monoclonal antibodies against haematological cancer cell lines in vitro. Scientific Reports, 14(1), Article 28239. https://doi.org/10.1038/s41598-024-79690-8

Complement-dependent cytotoxicity (CDC) is a primary mechanism-of-action of monoclonal antibody (mAb) immunotherapies used to treat haematological cancers, including rituximab and daratumumab. However, mAb efficacy may be limited by reduced bioavaila... Read More about Downhill running does not alter blood C1q availability or complement-dependent cytotoxicity of therapeutic monoclonal antibodies against haematological cancer cell lines in vitro.

Characterising how a single bout of exercise in people with myeloma affects clonal plasma cell and immune effector cell frequency in blood, and daratumumab efficacy in vitro (2024)
Journal Article
Collier-Bain, H. D., Emery, A., Brown, F. F., Causer, A. J., Oliver, R., Eddy, R., Leach, S., Graby, J., Augustine, D., Moore, S., Crowe, J., Murray, J., Turner, J. E., & Campbell, J. P. (2024). Characterising how a single bout of exercise in people with myeloma affects clonal plasma cell and immune effector cell frequency in blood, and daratumumab efficacy in vitro. Brain, Behavior, and Immunity - Health, 42, Article 100865. https://doi.org/10.1016/j.bbih.2024.100865

Multiple myeloma is a haematological cancer characterised by the accumulation of clonal plasma cells in the bone marrow and is commonly treated with daratumumab, an anti-CD38 monoclonal antibody immunotherapy. Daratumumab often fails to induce string... Read More about Characterising how a single bout of exercise in people with myeloma affects clonal plasma cell and immune effector cell frequency in blood, and daratumumab efficacy in vitro.

A single bout of vigorous intensity exercise enhances the efficacy of rituximab against human chronic lymphocytic leukaemia B-cells ex vivo (2024)
Journal Article
Collier-Bain, H. D., Emery, A., Causer, A. J., Brown, F. F., Oliver, R., Dutton, D., Crowe, J., Augustine, D., Graby, J., Leach, S., Eddy, R., Rothschild-Rodriguez, D., Gray, J. C., Cragg, M. S., Cleary, K. L., Moore, S., Murray, J., Turner, J. E., & Campbell, J. P. (2024). A single bout of vigorous intensity exercise enhances the efficacy of rituximab against human chronic lymphocytic leukaemia B-cells ex vivo. Brain, Behavior, and Immunity, 118, 468-479. https://doi.org/10.1016/j.bbi.2024.03.023

Chronic lymphocytic leukaemia (CLL) is characterised by the clonal proliferation and accumulation of mature B-cells and is often treated with rituximab, an anti-CD20 monoclonal antibody immunotherapy. Rituximab often fails to induce stringent disease... Read More about A single bout of vigorous intensity exercise enhances the efficacy of rituximab against human chronic lymphocytic leukaemia B-cells ex vivo.

Safety and Feasibility of a 16-Week Progressive Exercise Intervention in Treatment Naïve Chronic Lymphocytic Leukaemia (2023)
Journal Article
Brown, F. F., Oliver, R., Causer, A. J., Collier-Bain, H. D., Emery, A., Eddy, R., Dutton, D., Crowe, J., Augustine, D., Graby, J., Rees, D., Rothschild Rodriguez, D., Peacock, O., Moore, S., Murray, J., Turner, J. E., & Campbell, J. P. (2023). Safety and Feasibility of a 16-Week Progressive Exercise Intervention in Treatment Naïve Chronic Lymphocytic Leukaemia. Blood, 142(suppl 1), 6533. https://doi.org/10.1182/blood-2023-186956

A growing body of evidence from preclinical and human epidemiology studies of multiple cancer types indicate that physical activity can delay or avert the outgrowth of cancer, in a mechanistic process that may involve exercise-indu... Read More about Safety and Feasibility of a 16-Week Progressive Exercise Intervention in Treatment Naïve Chronic Lymphocytic Leukaemia.

Harnessing the immunomodulatory effects of exercise to enhance the efficacy of monoclonal antibody therapies against B-cell haematological cancers: a narrative review (2023)
Journal Article
Collier-Bain, H. D., Brown, F. F., Causer, A. J., Emery, A., Oliver, R., Moore, S., Murray, J., Turner, J. E., & Campbell, J. P. (2023). Harnessing the immunomodulatory effects of exercise to enhance the efficacy of monoclonal antibody therapies against B-cell haematological cancers: a narrative review. Frontiers in Oncology, 13, Article 1244090. https://doi.org/10.3389/fonc.2023.1244090

Therapeutic monoclonal antibodies (mAbs) are standard care for many B-cell haematological cancers. The modes of action for these mAbs include: induction of cancer cell lysis by activating Fcγ-receptors on innate immune cells; opsonising target cells... Read More about Harnessing the immunomodulatory effects of exercise to enhance the efficacy of monoclonal antibody therapies against B-cell haematological cancers: a narrative review.

Patient–clinician dynamics in remote consultations: a qualitative study of cardiology and rheumatology outpatient clinics in the UK (2023)
Journal Article
Grey, E., Brown, F., Smith, P., Springett, D., Augustine, D., Sengupta, R., Peacock, O., & Gillison, F. (2023). Patient–clinician dynamics in remote consultations: a qualitative study of cardiology and rheumatology outpatient clinics in the UK. BMJ Open, 13(5), Article e070923. https://doi.org/10.1136/bmjopen-2022-070923

Objective: Explore the experiences of patients and clinicians in rheumatology and cardiology outpatient clinics during the first year of the COVID-19 pandemic, focusing on the impact of remote consultations on interpersonal dynamics.

Design: Quali... Read More about Patient–clinician dynamics in remote consultations: a qualitative study of cardiology and rheumatology outpatient clinics in the UK.

“A disembodied voice over the telephone”: a qualitative study of healthcare practitioners’ experiences in geriatric medicine (2023)
Journal Article
Brown, F., Sanders, I., Watkins, R., Grey, E., Smith, P., Springett, D., Welsh, T., & Gillison, F. (2023). “A disembodied voice over the telephone”: a qualitative study of healthcare practitioners’ experiences in geriatric medicine. BMC Geriatrics, 23, Article 270. https://doi.org/10.1186/s12877-023-03909-y

Objectives: This study explored the experience of delivering care remotely among practitioners in a UK geriatric medicine clinic.

Methods: Nine semi-structured interviews were conducted with consultants (n = 5), nurses (n = 2), a speech and langua... Read More about “A disembodied voice over the telephone”: a qualitative study of healthcare practitioners’ experiences in geriatric medicine.

The effects of exercise on complement system proteins in humans: a systematic scoping review (2022)
Journal Article
Rothschild-Rodriguez, D., Causer, A. J., Brown, F. F., Collier-Bain, H. D., Moore, S., Murray, J., Turner, J. E., & Campbell, J. P. (2022). The effects of exercise on complement system proteins in humans: a systematic scoping review. Exercise Immunology Review, 28, 58-92

Background: The complement system is comprised of the classical , lectin and alternative pathways that result in the formation of: pro-inflammatory anaphylatoxins; opsonins that label cells for phagocytic removal; and, a membrane attack complex that... Read More about The effects of exercise on complement system proteins in humans: a systematic scoping review.

‘You’re kind of left to your own devices’: a qualitative focus group study of patients with breast, prostate or blood cancer at a hospital in the South West of England, exploring their engagement with exercise and physical activity during cancer treatment and in the months following standard care (2022)
Journal Article
Smith, S. K., Wiltshire, G., Brown, F. F., Dhillon, H., Osborn, M., Wexler, S., Beresford, M., Tooley, M. A., & Turner, J. E. (2022). ‘You’re kind of left to your own devices’: a qualitative focus group study of patients with breast, prostate or blood cancer at a hospital in the South West of England, exploring their engagement with exercise and physical activity during cancer treatment and in the months following standard care. BMJ Open, 12(3), Article e056132. https://doi.org/10.1136/bmjopen-2021-056132

Objectives: The aim of this study was to explore the experiences of patients with breast, prostate or blood cancer, regarding their (1) engagement with exercise and physical activity during treatment and in the months following standard care, and (2)... Read More about ‘You’re kind of left to your own devices’: a qualitative focus group study of patients with breast, prostate or blood cancer at a hospital in the South West of England, exploring their engagement with exercise and physical activity during cancer treatment and in the months following standard care.