Outputs (3)

The potential virulence of Listeria monocytogenes strains isolated from fresh produce processing facilities as determined by an invertebrate Galleria mellonella model (2024)
Journal Article
Umaru, B., de Llanos Frutos, R., Donnellan, S., Smith, A., Flockhart, A., Singleton, I., & Wheelhouse, N. (2024). The potential virulence of Listeria monocytogenes strains isolated from fresh produce processing facilities as determined by an invertebrate Galleria mellonella model. PLOS ONE, 19(12), e0311839. https://doi.org/10.1371/journal.pone.0311839

Listeria monocytogenes, a bacterium responsible for listeriosis, is an environmental and food-borne pathogen that poses a particular risk to pregnant women and the elderly. While traditionally associated with animal products, ready-to-eat salads are... Read More about The potential virulence of Listeria monocytogenes strains isolated from fresh produce processing facilities as determined by an invertebrate Galleria mellonella model.

Evaluation of the protective efficacy of different doses of a Chlamydia abortus subcellular vaccine in a pregnant sheep challenge model for ovine enzootic abortion (2024)
Journal Article
Livingstone, M., Aitchison, K., Palarea-Albaladejo, J., Chianini, F., Silvia Rocchi, M., Gastón Caspe, S., Underwood, C., Flockhart, A., Wheelhouse, N., Entrican, G., Ranjan Wattegedera, S., & Longbottom, D. (2024). Evaluation of the protective efficacy of different doses of a Chlamydia abortus subcellular vaccine in a pregnant sheep challenge model for ovine enzootic abortion. Animals, 14(20), Article 3004. https://doi.org/10.3390/ani14203004

Chlamydia abortus causes the disease ovine enzootic abortion, which is one of the most infectious causes of foetal death in small ruminants worldwide. While the disease can be controlled using live and inactivated commercial vaccines, there is scope... Read More about Evaluation of the protective efficacy of different doses of a Chlamydia abortus subcellular vaccine in a pregnant sheep challenge model for ovine enzootic abortion.

Design of a new class of broad-spectrum therapeutics targeted to drug-resistant bacteria (2024)
Journal Article
Surendran, A., Turnbull, A., Flockhart, A., Findlay-Greene, F., Nowosielska, M., Morrison, D., Mincher, D. J., & Donnellan, S. (2024). Design of a new class of broad-spectrum therapeutics targeted to drug-resistant bacteria. All Life, 17(1), Article 2379309. https://doi.org/10.1080/26895293.2024.2379309

We hypothesise that antimicrobial resistance (AMR) cannot be overcome by simply ‘drugging’ single biological targets, therefore, our focus is developing broad-spectrum therapeutics. Herein we present the synthesis of two novel spacer-linked, anthraqu... Read More about Design of a new class of broad-spectrum therapeutics targeted to drug-resistant bacteria.