Sex-specific disease aetiology from developmental steroid insults: mechanistic understanding and biomarker development towards disease prevention

Early pregnancy maternal progesterone administration alters pituitary and testis function and steroid profile in male fetuses (2020)
Journal Article
Siemienowicz, K. J., Wang, Y., Marečková, M., Nio-Kobayashi, J., Fowler, P. A., Rae, M. T., & Duncan, W. C. (2020). Early pregnancy maternal progesterone administration alters pituitary and testis function and steroid profile in male fetuses. Scientific Reports, 10(1), https://doi.org/10.1038/s41598-020-78976-x

Maternal exposure to increased steroid hormones, including estrogens, androgens or glucocorticoids during pregnancy results in chronic conditions in offspring that manifest in adulthood. Little is known about effects of progesterone administration in... Read More about Early pregnancy maternal progesterone administration alters pituitary and testis function and steroid profile in male fetuses.

Aberrant subcutaneous adipogenesis precedes adult metabolic dysfunction in an ovine model of polycystic ovary syndrome (PCOS) (2020)
Journal Article
Siemienowicz, K. J., Coukan, F., Franks, S., Rae, M. T., & Colin Duncan, W. (2021). Aberrant subcutaneous adipogenesis precedes adult metabolic dysfunction in an ovine model of polycystic ovary syndrome (PCOS). Molecular and Cellular Endocrinology, 519, Article 111042. https://doi.org/10.1016/j.mce.2020.111042

Polycystic ovary syndrome (PCOS) affects over 10% of women. Insulin resistance, elevated free fatty acids (FFAs) and increased adiposity are key factors contributing to metabolic dysfunction in PCOS. We hypothesised that aberrant adipogenesis duri... Read More about Aberrant subcutaneous adipogenesis precedes adult metabolic dysfunction in an ovine model of polycystic ovary syndrome (PCOS).