Sex-specific disease aetiology from developmental steroid insults: mechanistic understanding and biomarker development towards disease prevention

Hepatic Mitochondrial Dysfunction and Risk of Liver Disease in an Ovine Model of “PCOS Males” (2022)
Journal Article
Siemienowicz, K. J., Filis, P., Thomas, J., Fowler, P. A., Duncan, W. C., & Rae, M. T. (2022). Hepatic Mitochondrial Dysfunction and Risk of Liver Disease in an Ovine Model of “PCOS Males”. Biomedicines, 10(6), Article 1291. https://doi.org/10.3390/biomedicines10061291

First-degree male relatives of polycystic ovary syndrome (PCOS) sufferers can develop metabolic abnormalities evidenced by elevated circulating cholesterol and triglycerides, suggestive of a male PCOS equivalent. Similarly, male sheep overexposed to... Read More about Hepatic Mitochondrial Dysfunction and Risk of Liver Disease in an Ovine Model of “PCOS Males”.