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All Outputs (20)

Student engagement and curriculum design within Clinical Exercise Physiology (2023)
Presentation / Conference Contribution
Leggate, M., Pitkethly, A., & De Klerk, T. (2023, April). Student engagement and curriculum design within Clinical Exercise Physiology. Paper presented at Innovation and Updates in Teaching and Student Education across Physiology and STEM in the UK, Leeds, UK

This project aims to determine the perceptions of both graduate and current students studying on a MSc programme in Clinical Exercise Science. This project aims to redevelop our current provision to align with the new Clinical Exercise Physiology Fra... Read More about Student engagement and curriculum design within Clinical Exercise Physiology.

Exercise acutely increases vitamin D receptor expression in T lymphocytes in vitamin D-deficient men, independent of age (2021)
Journal Article
Lithgow, H., Florida‐James, G., Ross, M., Duncan, G., & Leggate, M. (2021). Exercise acutely increases vitamin D receptor expression in T lymphocytes in vitamin D-deficient men, independent of age. Experimental Physiology, 106(7), 1460-1469. https://doi.org/10.1113/ep089480

Vitamin D plays a key role in the modulation of the immune system, mediated through the intracellular vitamin D receptor (VDR). Exercise has been shown to influence the activity and availability of the VDR. This study aimed to investigate the effect... Read More about Exercise acutely increases vitamin D receptor expression in T lymphocytes in vitamin D-deficient men, independent of age.

The effects of age and acute aerobic and resistance exercise on circulating T lymphocyte vitamin D receptor (VDR) expression in healthy males (2019)
Presentation / Conference Contribution
Leggate, M., Florida-James, G., Ross, M., Jurevicius, M., Duncan, G., & Lithgow, H. (2019, December). The effects of age and acute aerobic and resistance exercise on circulating T lymphocyte vitamin D receptor (VDR) expression in healthy males. Presented at Future Physiology, Liverpool, UK

A low vitamin D status has been identified as an association risk factor in the etiology of numerous chronic diseases, with older adults identified as generally more deficient than younger populations. Exercise has been shown to act as a direct and i... Read More about The effects of age and acute aerobic and resistance exercise on circulating T lymphocyte vitamin D receptor (VDR) expression in healthy males.

The effect of acute exercise on T cell vitamin D receptor (VDR) expression in young and older males (2018)
Presentation / Conference Contribution
Leggate, M., Lithgow, H., Florida-James, G., & Barlow, P. (2018, July). The effect of acute exercise on T cell vitamin D receptor (VDR) expression in young and older males. Presented at 23rd Annual Congress of the European College of Sport Science (ECSS), Dublin, Ireland

A low vitamin D status has been identified as an association risk factor in the etiology of numerous chronic diseases, with older adults identified as generally more deficient than younger populations. Exercise has been shown to act as a direct and i... Read More about The effect of acute exercise on T cell vitamin D receptor (VDR) expression in young and older males.

The combined effect of high-intensity intermittent training and vitamin D supplementation on glycemic control in overweight and obese adults (2018)
Journal Article
Lithgow, H. M., Florida-James, G., & Leggate, M. (2018). The combined effect of high-intensity intermittent training and vitamin D supplementation on glycemic control in overweight and obese adults. Physiological Reports, 6(9), Article e13684. https://doi.org/10.14814/phy2.13684

High intensity intermittent training (HIIT) has been shown to reduce the risk of chronic conditions including the development of type 2 diabetes mellitus (T2DM). Independently, a low vitamin D status has also been linked to the prevalence of T2DM. Th... Read More about The combined effect of high-intensity intermittent training and vitamin D supplementation on glycemic control in overweight and obese adults.

The Effect of a Single Bout of High Intensity Intermittent Exercise on Glucose Tolerance in Non-diabetic Older Adults (2018)
Journal Article
Lithgow, H., & Leggate, M. (2018). The Effect of a Single Bout of High Intensity Intermittent Exercise on Glucose Tolerance in Non-diabetic Older Adults. International Journal of Exercise Science, 11(3), 95-105

Our aim was to investigate the acute effects of a single bout of high intensity intermittent training (HIIT) on glucose tolerance and other physiological and metabolic markers in non-diabetic older adults. Fourteen healthy older adults (age, 64 ± 2 y... Read More about The Effect of a Single Bout of High Intensity Intermittent Exercise on Glucose Tolerance in Non-diabetic Older Adults.

The combined effect of high‐intensity intermittent training and vitamin D supplementation on glycemic control in overweight and obese adults (2017)
Presentation / Conference Contribution
Leggate, M., Lithgow, H., & Florida-James, G. (2017, May). The combined effect of high‐intensity intermittent training and vitamin D supplementation on glycemic control in overweight and obese adults. Poster presented at Cell Symposia: Exercise Metabolism, Gothenburg, Sweden

The aim of this study was to investigate if there was a synergistic effect of high intensity intermittent training (HIIT) and vitamin D3 supplementation on glycaemic control. Twenty participants (age, 34±9y; BMI, 31.4±2.8 kg·m-2) completed 6 weeks HI... Read More about The combined effect of high‐intensity intermittent training and vitamin D supplementation on glycemic control in overweight and obese adults.

Subclinical diastolic dysfunction in young adults with Type 2 diabetes mellitus: a multiparametric contrast-enhanced cardiovascular magnetic resonance pilot study assessing potential mechanisms (2014)
Journal Article
Khan, J. N., Wilmot, E. G., Leggate, M., Singh, A., Yates, T., Nimmo, M., …McCann, G. P. (2014). Subclinical diastolic dysfunction in young adults with Type 2 diabetes mellitus: a multiparametric contrast-enhanced cardiovascular magnetic resonance pilot study assessing potential mechanisms. European heart journal cardiovascular Imaging, 15(11), 1263-1269. https://doi.org/10.1093/ehjci/jeu121


Aims To assess the cardiac, vascular, anthropometric, and biochemical determinants of subclinical diastolic dysfunction in younger adults with Type 2 diabetes mellitus (T2DM) using multiparametric contrast-enhanced cardiovascular magnetic resonance... Read More about Subclinical diastolic dysfunction in young adults with Type 2 diabetes mellitus: a multiparametric contrast-enhanced cardiovascular magnetic resonance pilot study assessing potential mechanisms.

Type 2 diabetes mellitus and obesity in young adults: the extreme phenotype with early cardiovascular dysfunction (2014)
Journal Article
Wilmot, E. G., Leggate, M., Khan, J. N., Yates, T., Gorely, T., Bodicoat, D. H., Khunti, K., Kuijer, J. P. A., Gray, L. J., Singh, A., Clarysse, P., Croisille, P., Nimmo, M. A., McCann, G. P., & Davies, M. J. (2014). Type 2 diabetes mellitus and obesity in young adults: the extreme phenotype with early cardiovascular dysfunction. Diabetic medicine : a journal of the British Diabetic Association, 31(7), 794-798. https://doi.org/10.1111/dme.12431

Aim

A pilot study to phenotype young adults (< 40 years) with Type 2 diabetes mellitus.
Methods

Twenty people with Type 2 diabetes (aged 18–40 years), 10 lean and 10 obese control subjects underwent detailed assessment, including tagged cardia... Read More about Type 2 diabetes mellitus and obesity in young adults: the extreme phenotype with early cardiovascular dysfunction.

The effect of physical activity on mediators of inflammation (2013)
Journal Article
Nimmo, M. A., Leggate, M., Viana, J. L., & King, J. A. (2013). The effect of physical activity on mediators of inflammation. Diabetes, obesity & metabolism, 15(s3), 51-60. https://doi.org/10.1111/dom.12156

Being physically active and undertaking exercise on a regular basis are critical lifestyle behaviours which protect against the development of numerous chronic metabolic conditions. One of the key mechanisms by which physical activity exerts favourab... Read More about The effect of physical activity on mediators of inflammation.

Determination of inflammatory and prominent proteomic changes in plasma and adipose tissue after high-intensity intermittent training in overweight and obese males (2012)
Journal Article
Leggate, M., Carter, W. G., Evans, M. J. C., Vennard, R. A., Sribala-Sundaram, S., & Nimmo, M. A. (2012). Determination of inflammatory and prominent proteomic changes in plasma and adipose tissue after high-intensity intermittent training in overweight and obese males. Journal of Applied Physiology, 112, 1353-1360. https://doi.org/10.1152/japplphysiol.01080.2011

This study aimed to determine whether 2 wk of high-intensity intermittent training (HIIT) altered inflammatory status in plasma and adipose tissue in overweight and obese males. Twelve participants [mean (SD): age 23.7 (5.2) yr, body mass 91.0 (8.0)... Read More about Determination of inflammatory and prominent proteomic changes in plasma and adipose tissue after high-intensity intermittent training in overweight and obese males.

Circulating hormone and cytokine response to low-load resistance training with blood flow restriction in older men (2012)
Journal Article
Patterson, S. D., Leggate, M., Nimmo, M. A., & Ferguson, R. A. (2013). Circulating hormone and cytokine response to low-load resistance training with blood flow restriction in older men. European Journal of Applied Physiology, 113(3), 713-719. https://doi.org/10.1007/s00421-012-2479-5

It has been suggested that circulating hormones and cytokines are important in the adaptive response to low-load resistance training (LLRT) with blood flow restriction (BFR); however, their response following this type of training in older men is unc... Read More about Circulating hormone and cytokine response to low-load resistance training with blood flow restriction in older men.

The response of interleukin-6 and soluble interleukin-6 receptor isoforms following intermittent high intensity and continuous moderate intensity cycling (2010)
Journal Article
Leggate, M., Nowell, M. A., Jones, S. A., & Nimmo, M. A. (2010). The response of interleukin-6 and soluble interleukin-6 receptor isoforms following intermittent high intensity and continuous moderate intensity cycling. Cell Stress and Chaperones, 15, 827-833. https://doi.org/10.1007/s12192-010-0192-z

As interleukin-6 (IL-6), its soluble receptor (sIL-6R), and the IL-6/sIL-6R complex is transiently elevated in response to prolonged moderate-intensity exercise, this study investigated how these levels would be modulated by an acute bout of high-int... Read More about The response of interleukin-6 and soluble interleukin-6 receptor isoforms following intermittent high intensity and continuous moderate intensity cycling.

Individual responsiveness to exercise-induced fat loss is associated with change in resting substrate utilization (2009)
Journal Article
Barwell, N. D., Malkova, D., Leggate, M., & Gill, J. M. R. (2009). Individual responsiveness to exercise-induced fat loss is associated with change in resting substrate utilization. Metabolism, 58(9), 1320-1328. https://doi.org/10.1016/j.metabol.2009.04.016

Fat loss in response to exercise training varies between individuals, even when differences in compliance to the exercise program are accounted for. The purpose of this study was to investigate whether individual variation in change in fasting respir... Read More about Individual responsiveness to exercise-induced fat loss is associated with change in resting substrate utilization.

The response of circulating levels of the IL-6/IL-6R complex to exercise (2009)
Presentation / Conference Contribution
Leggate, M., Gray, S., & Nimmo, M. (2009, July). The response of circulating levels of the IL-6/IL-6R complex to exercise. Poster presented at Obesity & Insulin Resistance – From Cell to Whole Body: The Benefits of Exercise, University of Birmingham, UK

Leggate, M., Gray, S., & Nimmo, M. (2009, July). The response of circulating levels of the IL-6/IL-6R complex to exercise. Poster presented at Obesity & Insulin Resistance – From Cell to Whole Body: The Benefits of Exercise, University of Birmingham,... Read More about The response of circulating levels of the IL-6/IL-6R complex to exercise.

The response of circulating levels of the interleukin-6/interleukin-6 receptor complex to exercise in young men (2009)
Journal Article
Gray, S. R., Clifford, M., Lancaster, R., Leggate, M., Davies, M., & Nimmo, M. A. (2009). The response of circulating levels of the interleukin-6/interleukin-6 receptor complex to exercise in young men. Cytokine, 47(2), 98-102. https://doi.org/10.1016/j.cyto.2009.05.011

The formation of an interleukin-6/IL-6 receptor (IL-6/IL-6R) complex increases the biological activity and half-life of IL-6, with its response to exercise currently unknown. The aim of the present study was to determine the response of circulating l... Read More about The response of circulating levels of the interleukin-6/interleukin-6 receptor complex to exercise in young men.