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Optimizing polypharmacy management in the elderly: a comprehensive European benchmarking survey and the development of an innovative online benchmarking application (2023)
Journal Article
Kardas, P., Mair, A., Stewart, D., & Lewek, P. (2023). Optimizing polypharmacy management in the elderly: a comprehensive European benchmarking survey and the development of an innovative online benchmarking application. Frontiers in Pharmacology, 14, Article 1254912. https://doi.org/10.3389/fphar.2023.1254912

Background: Polypharmacy, defined as the simultaneous use of multiple medications by a patient, is a worldwide problem of rising prevalence. Paving the way for drug interactions, adverse drug reactions and non-adherence, it leads to negative health o... Read More about Optimizing polypharmacy management in the elderly: a comprehensive European benchmarking survey and the development of an innovative online benchmarking application.

Optimizing pharmacotherapy and deprescribing strategies in older adults living with multimorbidity and polypharmacy: EuGMS SIG on pharmacology position paper (2023)
Journal Article
van Poelgeest, E., Seppala, L., Bahat, G., Ilhan, B., Mair, A., van Marum, R., …van der Velde, N. (2023). Optimizing pharmacotherapy and deprescribing strategies in older adults living with multimorbidity and polypharmacy: EuGMS SIG on pharmacology position paper. European Geriatric Medicine, 14(6), 1195-1209. https://doi.org/10.1007/s41999-023-00872-0

Key summary points: Aim: To summarize the literature on medication review and deprescribing in older adults, and formulate recommendations to improve prescribing medications in older, multimorbid adults with polypharmacy. Findings: Current evidence d... Read More about Optimizing pharmacotherapy and deprescribing strategies in older adults living with multimorbidity and polypharmacy: EuGMS SIG on pharmacology position paper.

Recommendations for wider adoption of clinical pharmacy in Central and Eastern Europe in order to optimise pharmacotherapy and improve patient outcomes (2023)
Journal Article
Urbańczyk, K., Guntschnig, S., Antoniadis, V., Falamic, S., Kovacevic, T., Kurczewska-Michalak, M., …Kardas, P. (2023). Recommendations for wider adoption of clinical pharmacy in Central and Eastern Europe in order to optimise pharmacotherapy and improve patient outcomes. Frontiers in Pharmacology, 14, Article 1244151. https://doi.org/10.3389/fphar.2023.1244151

Clinical pharmacy as an area of practice, education and research started developing around the 1960s when pharmacists across the globe gradually identified the need to focus more on ensuring the appropriate use of medicines to improve patient outcome... Read More about Recommendations for wider adoption of clinical pharmacy in Central and Eastern Europe in order to optimise pharmacotherapy and improve patient outcomes.

Polypharmacy and Integrated Care (2021)
Book Chapter
Mair, A., & Alonso, A. (2021). Polypharmacy and Integrated Care. In V. Amelung, V. Stein, E. Suter, N. Goodwin, E. Nolte, & R. Balicer (Eds.), Handbook Integrated Care (453-477). Cham: Springer. https://doi.org/10.1007/978-3-030-69262-9_27

Safe and effective pharmacological treatment remains one of the greatest challenges in medicine, where models of healthcare delivery lag behind the enormous growth in single disease focused treatment with medicines. The implications for safe, efficie... Read More about Polypharmacy and Integrated Care.

Appropriate polypharmacy: a barometer for integrated care (2020)
Journal Article
Mair, A., Antoniadou, E., Hendry, A., & Gabrovec, B. (2021). Appropriate polypharmacy: a barometer for integrated care. Journal of Integrated Care, 29(2), 204-214. https://doi.org/10.1108/jica-04-2020-0019

Purpose Polypharmacy, the concurrent use of multiple medicines by one individual, is a common and growing challenge driven by an ageing population and the growing number of people living longer with chronic conditions. Up to 11% of unplanned hospita... Read More about Appropriate polypharmacy: a barometer for integrated care.

Current evidence on the impact of medication optimization or pharmacological interventions on frailty or aspects of frailty: a systematic review of randomized controlled trials (2020)
Journal Article
Pazan, F., Petrovic, M., Cherubini, A., Onder, G., Cruz-Jentoft, A. J., Denkinger, M., …Wehling, M. (2021). Current evidence on the impact of medication optimization or pharmacological interventions on frailty or aspects of frailty: a systematic review of randomized controlled trials. European Journal of Clinical Pharmacology, 77(1), 1-12. https://doi.org/10.1007/s00228-020-02951-8

Background Frailty and adverse drug effects are linked in the fact that polypharmacy is correlated with the severity of frailty; however, a causal relation has not been proven in older people with clinically manifest frailty. Methods A literatur... Read More about Current evidence on the impact of medication optimization or pharmacological interventions on frailty or aspects of frailty: a systematic review of randomized controlled trials.

Addressing the Challenge of Polypharmacy (2019)
Journal Article
Mair, A., Wilson, M., & Dreischulte, T. (2020). Addressing the Challenge of Polypharmacy. Annual Review of Pharmacology and Toxicology, 60(1), 661-681. https://doi.org/10.1146/annurev-pharmtox-010919-023508

Polypharmacy describes the concomitant use of multiple medicines and represents a growing global challenge attributable to aging populations with an increasing prevalence of multimorbidity. Polypharmacy can be appropriate but is problematic when the... Read More about Addressing the Challenge of Polypharmacy.

Next-generation ARIA care pathways for rhinitis and asthma: a model for multimorbid chronic diseases (2019)
Journal Article
Bousquet, J. J., the ARIA Study Group, Schünemann, H. J., Togias, A., Erhola, M., Hellings, P. W., …the MASK Study Group. (2019). Next-generation ARIA care pathways for rhinitis and asthma: a model for multimorbid chronic diseases. Clinical and Translational Allergy, 9, Article 44 (2019). https://doi.org/10.1186/s13601-019-0279-2

Background In all societies, the burden and cost of allergic and chronic respiratory diseases are increasing rapidly. Most economies are struggling to deliver modern health care effectively. There is a need to support the transformation of the healt... Read More about Next-generation ARIA care pathways for rhinitis and asthma: a model for multimorbid chronic diseases.

The polypharmacy programme in Scotland: realistic prescribing (2019)
Journal Article
Mair, A., Wilson, M., & Dreischulte, T. (2019). The polypharmacy programme in Scotland: realistic prescribing. Prescriber, 30(8), 10-16. https://doi.org/10.1002/psb.1779

Since 2012, NHS Scotland has published a series of polypharmacy guidelines to help clinicians address the many medication‐related problems arising from multimorbidity. Here, Alpana Mair, Chair of the guideline group, Martin Wilson and Tobias Dreischu... Read More about The polypharmacy programme in Scotland: realistic prescribing.

Medication Safety in Transitions of Care: Technical Report (2019)
Report
World Health Organisation. (2019). Medication Safety in Transitions of Care: Technical Report. Geneva: WHO

Medication discrepancies impact almost every patient that moves across transitions of care, e.g. admission to or discharge from hospital. WHO urges countries to prioritise early and sustained action to reduce medication-related harm arising at transi... Read More about Medication Safety in Transitions of Care: Technical Report.

Polypharmacy and pharmacovigilance: How they relate and why it matters (2019)
Journal Article
Mair, A. (2019). Polypharmacy and pharmacovigilance: How they relate and why it matters. Uppsala Reports, 80, 12-13

Patients with multiple medical conditions – and, consequently, needing multiple medications – present one of the greatest challenges currently facing health services.

ARIA pharmacy 2018 “Allergic rhinitis care pathways for community pharmacy”: AIRWAYS ICPs initiative (European Innovation Partnership on Active and Healthy Ageing, DG CONNECT and DG Santé), 
POLLAR (Impact of Air POLLution on Asthma and Rhinitis), 
GARD Demonstration project (2019)
Journal Article
Bosnic‐Anticevich, S., Costa, E., Menditto, E., Lourenço, O., Novellino, E., Bialek, S., …Bousquet, J. (2019). ARIA pharmacy 2018 “Allergic rhinitis care pathways for community pharmacy”: AIRWAYS ICPs initiative (European Innovation Partnership on Active and Healthy Ageing, DG CONNECT and DG Santé), 
POLLAR (Impact of Air POLLution on Asthma and Rhinitis), 
GARD Demonstration project. Allergy, 74(7), 1219-1236. https://doi.org/10.1111/all.13701

Pharmacists are trusted health care professionals. Many patients use over‐the‐counter (OTC) medications and are seen by pharmacists who are the initial point of contact for allergic rhinitis management in most countries. The role of pharmacists in in... Read More about ARIA pharmacy 2018 “Allergic rhinitis care pathways for community pharmacy”: AIRWAYS ICPs initiative (European Innovation Partnership on Active and Healthy Ageing, DG CONNECT and DG Santé), 
POLLAR (Impact of Air POLLution on Asthma and Rhinitis), 
GARD Demonstration project.

Age-Related Medicine (2019)
Journal Article
Wahlich, J., Orlu, M., Mair, A., Stegemann, S., & van Riet-Nales, D. (2019). Age-Related Medicine. Pharmaceutics, 11(4), Article 172. https://doi.org/10.3390/pharmaceutics11040172

A meeting organised by the Academy of Pharmaceutical Sciences focussed on the challenges of developing medicines for older adults. International experts discussed the complexity introduced by polypharmacy and multiple morbidities and how the risk–ben... Read More about Age-Related Medicine.

Adherence to treatment in allergic rhinitis using mobile technology. The MASK Study (2019)
Journal Article
Sheikh, A., De Vries, G., Anto, J. M., Annesi‐Maesano, I., Wickman, M., Hellings, P. W., …Menditto, E. (2019). Adherence to treatment in allergic rhinitis using mobile technology. The MASK Study. Clinical and Experimental Allergy, 49(4), 442-460. https://doi.org/10.1111/cea.13333

Background Mobile technology may help to better understand the adherence to treatment. MASK‐rhinitis (Mobile Airways Sentinel NetworK for allergic rhinitis) is a patient‐centred ICT system. A mobile phone app (the Allergy Diary) central to MASK is a... Read More about Adherence to treatment in allergic rhinitis using mobile technology. The MASK Study.

EuGMS Task and Finish group on Fall-Risk-Increasing Drugs (FRIDs): Position on Knowledge Dissemination, Management, and Future Research (2019)
Journal Article
Seppala, L. J., van der Velde, N., Masud, T., Blain, H., Petrovic, M., van der Cammen, T. J., …the EuGMS Special Interest Group on Pharmacology. (2019). EuGMS Task and Finish group on Fall-Risk-Increasing Drugs (FRIDs): Position on Knowledge Dissemination, Management, and Future Research. Drugs and Aging, 36(4), 299-307. https://doi.org/10.1007/s40266-018-0622-7

Falls are a major public health concern in the older population, and certain medication classes are a significant risk factor for falls. However, knowledge is lacking among both physicians and older people, including caregivers, concerning the role o... Read More about EuGMS Task and Finish group on Fall-Risk-Increasing Drugs (FRIDs): Position on Knowledge Dissemination, Management, and Future Research.