Discovery of potential RAF selective back pocket as a promising biological site for BRAF inhibitors targeting resistant melanoma opens the door for a new generation of kinase inhibitors: Design, synthesis, biological evaluation, and in silico molecular simulation
(2025)
Journal Article
Ammar, U., El-Din, M. G., Abdel-Maksoud, M., Ali, E., El-Gamal, M., Mahmoud, Z., Ahn, S., Nguyen, N. H., Kim, E., Jun, P. S., Deug, K. Y., Choi, H. S., Lee, K. H., Choi, G., & Oh, C.-H. (2025). Discovery of potential RAF selective back pocket as a promising biological site for BRAF inhibitors targeting resistant melanoma opens the door for a new generation of kinase inhibitors: Design, synthesis, biological evaluation, and in silico molecular simulation. International Journal of Biological Macromolecules, 320(Part 2), Article 145699. https://doi.org/10.1016/j.ijbiomac.2025.145699
Despite the approved combination of BRAFV600E and MEK inhibitors to treat drug-resistant melanoma, serious side effects associated with this combination have been reported, particularly referring to MEK inhibitors. In the current study, an isosteric...
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