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All Outputs (17)

Fibrosis is an early marker of subcutaneous adipose tissue dysfunction in polycystic ovary syndrome (PCOS) (2025)
Presentation / Conference Contribution
Wang, Y., McCredie, R., Rae, M., Cahill, A., Duncan, C., & Siemienowicz, K. (2025, May). Fibrosis is an early marker of subcutaneous adipose tissue dysfunction in polycystic ovary syndrome (PCOS). Presented at Joint Congress of the European Society for Paediatric Endocrinology (ESPE) and the European Society of Endocrinology (ESE) 2025: Connecting Endocrinology Across the Life Course, Copenhagen, Denmark

Prenatally androgenised female sheep are a clinically realistic model of PCOS. In adolescence (11 months of age) there is reduced subcutaneous adipogenesis and in adulthood (30 months of age) there is increased subcutaneous adipose tissue (SAT) dysfu... Read More about Fibrosis is an early marker of subcutaneous adipose tissue dysfunction in polycystic ovary syndrome (PCOS).

Excess adrenal androgen secretion is a consequence of in utero androgen excess in an ovine model of PCOS (2025)
Presentation / Conference Contribution
Rae, M., Ramaswamy, S., Siemienowicz, K., McNeilly, A., Howie, F., Wilson, K., Hogg, K., & Duncan, W. C. (2025, May). Excess adrenal androgen secretion is a consequence of in utero androgen excess in an ovine model of PCOS. Presented at Joint Congress of the European Society for Paediatric Endocrinology (ESPE) and the European Society of Endocrinology (ESE) 2025: Connecting Endocrinology Across the Life Course, Copenhagen, Denmark

Evidence for bone marrow adipose tissue dysfunction in polycystic ovary syndrome (PCOS) (2025)
Presentation / Conference Contribution
McCredie, R., Levate, G., Wang, Y., Rae, M., Duncan, C., & Siemienowicz, K. (2025, May). Evidence for bone marrow adipose tissue dysfunction in polycystic ovary syndrome (PCOS). Presented at Joint Congress of the European Society for Paediatric Endocrinology (ESPE) and the European Society of Endocrinology (ESE) 2025: Connecting Endocrinology Across the Life Course, Copenhagen, Denmark

The effect of intranasal insulin on post prandial thermogenesis in obese women with and without polycystic ovary syndrome (2025)
Presentation / Conference Contribution
Duncan, C., Wang, Y., McCredie, R., Franks, S., Fowler, P., Stimson, R., Rae, M., & Siemienowicz, K. (2025, May). The effect of intranasal insulin on post prandial thermogenesis in obese women with and without polycystic ovary syndrome. Presented at Joint Congress of the European Society for Paediatric Endocrinology (ESPE) and the European Society of Endocrinology (ESE) 2025: Connecting Endocrinology Across the Life Course, Copenhagen, Denmark

Assessing the toxicity of engineered nanomaterials in the male reproductive system: Developing improved methods and strategies for hazard assessment (2022)
Presentation / Conference Contribution
Ross, B. L., Malone, E. M., Rae, M. T., Bouwmeester, H., van der Zande, M., & Hutchison, G. R. (2022, March). Assessing the toxicity of engineered nanomaterials in the male reproductive system: Developing improved methods and strategies for hazard assessment. Poster presented at Society of Toxicology 61st Annual Meeting, San Diego, California

Dyslipidaemia and altered hepatic function in males - consequences of androgen excess in fetal life (2019)
Presentation / Conference Contribution
Siemienowicz, K., Filis, P., Shaw, S., Douglas, A., Thomas, J., Howie, F., Fowler, P., Duncan, C., & Rae, M. (2019, May). Dyslipidaemia and altered hepatic function in males - consequences of androgen excess in fetal life. Presented at 21st European Congress of Endocrinology, Lyon, France

Introduction: Adult male offspring of women with PCOS have increased dyslipidaemia, characterised by elevated triglycerides (TG), increased total and LDL-cholesterol (LDL-C), and hyperinsulinaemia. As altered intrauterine endocrine environments can ‘... Read More about Dyslipidaemia and altered hepatic function in males - consequences of androgen excess in fetal life.

Physical Activity Index influence on all-cause mortality and vascular health measures: Findings from the Framingham Heart Study. European Journal of Sport Sciences (2018)
Presentation / Conference Contribution
Muggeridge, D., Rae, M., Florida-James, G., & Ross, M. (2018, July). Physical Activity Index influence on all-cause mortality and vascular health measures: Findings from the Framingham Heart Study. European Journal of Sport Sciences. Presented at 23rd Annual Congress of the European College of Sport Science, Dublin, Ireland

Preferential activation of HIF-2 adaptive mechanisms in neuronal-like cells in response to hypoxia (2017)
Presentation / Conference Contribution
Fraser, J., Baudel, M., Rae, M., Darlison, M., & Poole, A. (2017, April). Preferential activation of HIF-2 adaptive mechanisms in neuronal-like cells in response to hypoxia. Poster presented at British Neuroscience Association - festival of neuroscience 2017

Stroke is a leading cause of death and disability worldwide. Blockage, or occlusion, of cerebral arteries causes irreversible neuronal damage as disrupted blood flow starves neurones of oxygen and glucose. The hypoxia inducible factors (HIFs) are mas... Read More about Preferential activation of HIF-2 adaptive mechanisms in neuronal-like cells in response to hypoxia.

The expression of the chloride co-transporters NKCC1 and KCC2 is reversed in the penumbra following (2017)
Presentation / Conference Contribution
Baudel, M., Rae, M., Fraser, J., & Poole, A. (2017, April). The expression of the chloride co-transporters NKCC1 and KCC2 is reversed in the penumbra following. Presented at BNA 2017

Stroke is one of the major causes of death and disability worldwide. The harm caused by the interruption of blood flow to the brain unfolds in the subsequent hours and days, so it is critical to identify new therapeutic targets that could reduce neur... Read More about The expression of the chloride co-transporters NKCC1 and KCC2 is reversed in the penumbra following.

Development of in vitro strategies to predict in vivo toxicity of engineered nanoparticles to the male reproductive system. (2016)
Presentation / Conference Contribution
Malone, E., Ross, B., Rae, M., Bouwmeester, H., Gosens, I., Cassee, F., Werner, E., Ślązak, M., & Hutchison, G. (2016, September). Development of in vitro strategies to predict in vivo toxicity of engineered nanoparticles to the male reproductive system. Poster presented at 11th International Particle Toxicology Conference

The introduction of engineered nanomaterials (ENM) to new materials and products requires informed risk
assessment. The altered physico-chemical properties of ENM mean traditional assays to evaluate toxicity
must be modified or validated to ensure... Read More about Development of in vitro strategies to predict in vivo toxicity of engineered nanoparticles to the male reproductive system..

Exaggerated metabolic changes during puberty precede adult obesity and hyperlipidemia in an ovine model of Polycystic Ovary Syndrome (PCOS) (2016)
Presentation / Conference Contribution
Siemienowicz, K., Coukan, F., Lerner, A., Franks, S., Rae, M., & Duncan, C. (2016, July). Exaggerated metabolic changes during puberty precede adult obesity and hyperlipidemia in an ovine model of Polycystic Ovary Syndrome (PCOS). Paper presented at Society for Reproduction and Fertility Annual Conference, Winchester

Altered adipocytes in an ovine model of polycystic ovary syndrome (2015)
Presentation / Conference Contribution
Siemienowicz, K., Couckan, F., Lerner, A., Franks, S., Rae, M., & Duncan, C. (2015, November). Altered adipocytes in an ovine model of polycystic ovary syndrome. Poster presented at Society for Endocrinology BES, Edinburgh

Obesity in PCOS: a consequence of prenatally programmed reduced energy expenditure (2015)
Presentation / Conference Contribution
Siemienowicz, K., Rae, M., Lerner, A., Franks, S., & Duncan, C. (2015, July). Obesity in PCOS: a consequence of prenatally programmed reduced energy expenditure. Paper presented at Society for Reproduction and Fertility Annual Conference, Oxford

Polycystic ovary syndrome, a common endocrine condition affecting up to 10% of women of reproductive age, is associated with an increased risk of developing insulin resistance and obesity. Obesity is associated with increased energy intake or reduced... Read More about Obesity in PCOS: a consequence of prenatally programmed reduced energy expenditure.

The pathophysiology of increased hepatic IGF1 expression in an ovine model of polycystic ovary syndrome (2014)
Presentation / Conference Contribution
Siemienowicz, K., Boswell, L., Carr, D., Mina, T., Connolly, F., Rae, M., & Duncan, C. (2014, May). The pathophysiology of increased hepatic IGF1 expression in an ovine model of polycystic ovary syndrome. Poster presented at 16th European Congress of Endocrinology, Wroclaw, Poland

Exposure of pregnant sheep to increased concentrations of testosterone during midgestation results in a PCOS-like condition in the female offspring that includes increased hepatic IGF1. The aim of this study was to investigate the molecular pathophys... Read More about The pathophysiology of increased hepatic IGF1 expression in an ovine model of polycystic ovary syndrome.