Human MHC Class I-restricted high avidity CD4 + T cells generated by co-transfer of TCR and CD8 mediate efficient tumor rejection in vivo
(2013)
Journal Article
Xue, S.-A., Gao, L., Ahmadi, M., Ghorashian, S., Barros, R. D., Pospori, C., Holler, A., Wright, G., Thomas, S., Topp, M., Morris, E. C., & Stauss, H. J. (2013). Human MHC Class I-restricted high avidity CD4 + T cells generated by co-transfer of TCR and CD8 mediate efficient tumor rejection in vivo. OncoImmunology, 2(1), Article e22590. https://doi.org/10.4161/onci.22590
In this study, we generated human MHC Class I-restricted CD4+ T cells specific for Epstein-Barr virus (EBV) and cytomegalovirus (CMV), two herpesviridae associated with lymphoma, nasopharyngeal carcinoma and medulloblastoma, respectively. Retroviral... Read More about Human MHC Class I-restricted high avidity CD4 + T cells generated by co-transfer of TCR and CD8 mediate efficient tumor rejection in vivo.