All Outputs (25)

P1‐066: Dietary restriction delays ageing, but not neuronal pathology, in drosophila models of Alzheimer's disease (2008)
Presentation / Conference Contribution
Kerr, F., Partridge, L., & AddNeuroMed consortium. (2008, July). P1‐066: Dietary restriction delays ageing, but not neuronal pathology, in drosophila models of Alzheimer's disease. Presented at Alzheimer's Association International Conference on Alzheimer's Disease, Chicago, Illinois

Background
Dietary restriction (DR) extends lifespan in diverse organisms and can delay a range of ageing-related diseases including Alzheimer's disease (AD), whereas high-fat diets are suggested to be an important environmental risk factor for AD.... Read More about P1‐066: Dietary restriction delays ageing, but not neuronal pathology, in drosophila models of Alzheimer's disease.

Hyperphosphorylation of tau and neurofilaments and activation of CDK5 and ERK1/2 in PTEN-deficient cerebella (2007)
Journal Article
Nayeem, N., Kerr, F., Naumann, H., Linehan, J., Lovestone, S., & Brandner, S. (2007). Hyperphosphorylation of tau and neurofilaments and activation of CDK5 and ERK1/2 in PTEN-deficient cerebella. Molecular and Cellular Neuroscience, 34(3), 400-408. https://doi.org/10.1016/j.mcn.2006.11.014

Inherited mutations to the tumor suppressor PTEN sporadically lead to cerebellar gangliocytoma characterized by migration defects. This has been modeled by CNS-specific PTEN ablation in mice, but the underlying mechanism cannot be explained by the kn... Read More about Hyperphosphorylation of tau and neurofilaments and activation of CDK5 and ERK1/2 in PTEN-deficient cerebella.

PTEN, a negative regulator of PI3 kinase signalling, alters tau phosphorylation in cells by mechanisms independent of GSK-3 (2006)
Journal Article
Kerr, F., Rickle, A., Nayeem, N., Brandner, S., Cowburn, R. F., & Lovestone, S. (2006). PTEN, a negative regulator of PI3 kinase signalling, alters tau phosphorylation in cells by mechanisms independent of GSK-3. FEBS Letters, 580(13), 3121-3128. https://doi.org/10.1016/j.febslet.2006.04.064

Deregulation of PTEN/Akt signalling has been recently implicated in the pathogenesis of Alzheimer's disease (AD), but the effects on the molecular processes underlying AD pathology have not yet been fully described. Here we report that overexpression... Read More about PTEN, a negative regulator of PI3 kinase signalling, alters tau phosphorylation in cells by mechanisms independent of GSK-3.

School Students as Drosophila Experimenters (2005)
Journal Article
Siyad, F., Griffiths, J., Janjua, F., Jackson, E., Rodrigues, I., Kerr, F., Mackay, D., & Lovestone, S. (2005). School Students as Drosophila Experimenters. PLOS Biology, 3(7), Article e246. https://doi.org/10.1371/journal.pbio.0030246

School students as Drosophila experimenters.

Glycogen synthase kinase-3 is increased in white cells early in Alzheimer's disease (2004)
Journal Article
Hye, A., Kerr, F., Archer, N., Foy, C., Poppe, M., Brown, R., Hamilton, G., Powell, J., Anderton, B., & Lovestone, S. (2004). Glycogen synthase kinase-3 is increased in white cells early in Alzheimer's disease. Neuroscience Letters, 373(1), 1-4. https://doi.org/10.1016/j.neulet.2004.10.031

Alzheimer's disease (AD) is a disorder without a molecular marker in peripheral tissues or a disease modifying treatment. As increasing evidence has suggested a role for glycogen synthase kinase-3 (GSK-3) in the pathogenesis of the condition we measu... Read More about Glycogen synthase kinase-3 is increased in white cells early in Alzheimer's disease.