All Outputs (3)

Characterisation of autophagy induction by the thiopurine drugs azathioprine, mercaptopurine and thioguanine in THP-1 macrophages (2024)
Journal Article
Masson, C. D., Findlay-Greene, F., Henderson Sousa, F., Henderson, P., Fraser, J. A., Barlow, P. G., & Stevens, C. (online). Characterisation of autophagy induction by the thiopurine drugs azathioprine, mercaptopurine and thioguanine in THP-1 macrophages. Naunyn-Schmiedeberg's Archives of Pharmacology, https://doi.org/10.1007/s00210-024-03563-0

Purpose: Activating autophagy may be therapeutically beneficial, and we have previously shown that azathioprine (AZA), an immunomodulatory drug, induces autophagy. Here, we evaluated the induction of autophagy by the thiopurines AZA, mercaptopurine (... Read More about Characterisation of autophagy induction by the thiopurine drugs azathioprine, mercaptopurine and thioguanine in THP-1 macrophages.

Design of a new class of broad-spectrum therapeutics targeted to drug-resistant bacteria (2024)
Journal Article
Surendran, A., Turnbull, A., Flockhart, A., Findlay-Greene, F., Nowosielska, M., Morrison, D., Mincher, D. J., & Donnellan, S. (2024). Design of a new class of broad-spectrum therapeutics targeted to drug-resistant bacteria. All Life, 17(1), Article 2379309. https://doi.org/10.1080/26895293.2024.2379309

We hypothesise that antimicrobial resistance (AMR) cannot be overcome by simply ‘drugging’ single biological targets, therefore, our focus is developing broad-spectrum therapeutics. Herein we present the synthesis of two novel spacer-linked, anthraqu... Read More about Design of a new class of broad-spectrum therapeutics targeted to drug-resistant bacteria.

Evolution and immunopathology of chikungunya virus informs therapeutic development (2023)
Journal Article
Henderson Sousa, F., Ghaisani Komarudin, A., Findlay-Greene, F., Bowolaksono, A., Sasmono, R. T., Stevens, C., & Barlow, P. G. (2023). Evolution and immunopathology of chikungunya virus informs therapeutic development. Disease Models and Mechanisms, 16(4), https://doi.org/10.1242/dmm.049804

Chikungunya virus (CHIKV), a mosquito-borne alphavirus, is an emerging global threat identified in more than 60 countries across continents. The risk of CHIKV transmission is rising due to increased global interactions, year-round presence of mosquit... Read More about Evolution and immunopathology of chikungunya virus informs therapeutic development.