All Outputs (6)

Development of an immobilised artificial membrane liquid chromatography-mass spectrometry-based platform for high throughput and reliable assessments of the pulmonary permeability of drugs (2024)
Presentation / Conference Contribution
Dillon, A., Orzel, D., Russo, G., & Wiedmer, S. (2024, October). Development of an immobilised artificial membrane liquid chromatography-mass spectrometry-based platform for high throughput and reliable assessments of the pulmonary permeability of drugs. Poster presented at 34th International Symposium of Chromatography - ISC2024, Liverpool, UK

Immobilised artificial membrane liquid chromatography vs liposome electrokinetic capillary chromatography: Suitability in drug/bio membrane partitioning studies and effectiveness in the assessment of the passage of drugs through the respiratory mucosa (2024)
Journal Article
Orzel, D., Ravald, H., Dillon, A., Rantala, J., Wiedmer, S. K., & Russo, G. (2024). Immobilised artificial membrane liquid chromatography vs liposome electrokinetic capillary chromatography: Suitability in drug/bio membrane partitioning studies and effectiveness in the assessment of the passage of drugs through the respiratory mucosa. Journal of Chromatography A, 1734, Article 465286. https://doi.org/10.1016/j.chroma.2024.465286

This study pioneers a comparison of the application of biomimetic techniques, immobilised artificial membrane liquid chromatography (IAM LC) and liposome electrokinetic capillary chromatography (LEKC), for the prediction of pulmonary drug permeabilit... Read More about Immobilised artificial membrane liquid chromatography vs liposome electrokinetic capillary chromatography: Suitability in drug/bio membrane partitioning studies and effectiveness in the assessment of the passage of drugs through the respiratory mucosa.

The effectiveness of immobilised artificial membrane and liposome electrokinetic chromatography in predicting the pulmonary delivery of drugs in humans (2024)
Presentation / Conference Contribution
Orzel, D., Dillon, A., Russo, G., & Wiedmer, S. (2024, October). The effectiveness of immobilised artificial membrane and liposome electrokinetic chromatography in predicting the pulmonary delivery of drugs in humans. Poster presented at 34th International Symposium of Chromatography - ISC2024, Liverpool

Immobilized Artificial Membrane Liquid Chromatography vs Liposome Electrokinetic Chromatography: suitability in drug/bio membrane partitioning studies and effectiveness in the assessment of drugs’ passage through the respiratory mucosa (2024)
Presentation / Conference Contribution
Russo, G., Orzel, D., Dillon, A., Ravald, H., Rantala, J., & Wiedmer, S. K. (2024, October). Immobilized Artificial Membrane Liquid Chromatography vs Liposome Electrokinetic Chromatography: suitability in drug/bio membrane partitioning studies and effectiveness in the assessment of drugs’ passage through the respiratory mucosa. Paper presented at 34th International Symposium on Chromatography – ISC 2024, Liverpool

The effectiveness of biomimetic chromatography based methods in predictions of human pulmonary drug absorption (2023)
Presentation / Conference Contribution
Dillon, A., Orzek, D., MacCallum, J., & Russo, G. (2023, June). The effectiveness of biomimetic chromatography based methods in predictions of human pulmonary drug absorption. Poster presented at HPLC 2023

Nowadays immobilized artificial membranes (IAM) are commonly used for modelling drug
transport through biological lipid layers. In most published studies a compound’s lipophilicity
measurements are performed in isocratic conditions where a low pe... Read More about The effectiveness of biomimetic chromatography based methods in predictions of human pulmonary drug absorption.

Broadband Acoustic Resonance Dissolution Spectroscopy (BARDS): A rapid test for enteric coating thickness and integrity of controlled release pellet formulations (2018)
Journal Article
Alfarsi, A., Dillon, A., McSweeney, S., Krüse, J., Griffin, B., Devine, K., Sherry, P., Henken, S., Fitzpatrick, S., & Fitzpatrick, D. (2018). Broadband Acoustic Resonance Dissolution Spectroscopy (BARDS): A rapid test for enteric coating thickness and integrity of controlled release pellet formulations. International Journal of Pharmaceutics, 544(1), 31-38. https://doi.org/10.1016/j.ijpharm.2018.04.018

There are no rapid dissolution based tests for determining coating thickness, integrity and drug concentration in controlled release pellets either during production or post-production. The manufacture of pellets requires several coating steps depend... Read More about Broadband Acoustic Resonance Dissolution Spectroscopy (BARDS): A rapid test for enteric coating thickness and integrity of controlled release pellet formulations.