Slower Decline in C-Reactive Protein after an Inflammatory Insult Is Associated with Longer Survival in Older Hospitalised Patients

Barma, Maryam; Goodbrand, James A.; Donnan, Peter T.; McGilchrist, Mark M.; Frost, Helen; McMurdo, Marion E. T.; Witham, Miles D.

Abstract

Background Enhancing biological resilience may offer a novel way to prevent and ameliorate disease in older patients. We investigated whether changes in C-reactive protein (CRP), as a dynamic marker of the acute inflammatory response to diverse stressors, may provide a way to operationalize the concept of resilience in older adults. We tested this hypothesis by examining whether such changes could predict prognosis by identifying which individuals are at greater risk of 6-month mortality. Methods Analysis of prospective, routinely collected datasets containing data on hospitalization, clinical chemistry and rehabilitation outcomes for rehabilitation inpatients between 1999 and 2011. Maximum CRP response during acute illness and CRP recovery indices (time and slope of CRP decay to half maximum, and to

Citation

Barma, M., Goodbrand, J. A., Donnan, P. T., McGilchrist, M. M., Frost, H., McMurdo, M. E. T., & Witham, M. D. (2016). Slower Decline in C-Reactive Protein after an Inflammatory Insult Is Associated with Longer Survival in Older Hospitalised Patients. PLOS ONE, 11(7), Article e0159412. https://doi.org/10.1371/journal.pone.0159412

• Journal Article Type: Article
• Acceptance Date: Jul 2, 2016
• Online Publication Date: Jul 28, 2016
• Publication Date: Jul 2, 2016
• Deposit Date: Oct 12, 2017
• Publicly Available Date: Oct 12, 2017
• Journal: PLOS ONE
• Print ISSN: 1932-6203
• Publisher: Public Library of Science
• Peer Reviewed: Peer Reviewed
• Volume: 11
• Issue: 7
• Article Number: e0159412
• DOI: https://doi.org/10.1371/journal.pone.0159412
• Keywords: General Biochemistry, Genetics and Molecular Biology; General Agricultural and Biological Sciences; General Medicine
• Public URL: http://researchrepository.napier.ac.uk/Output/996910
• Contract Date: Oct 12, 2017