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Hypomorphic conditional deletion of E11/Podoplanin reveals a role in osteocyte dendrite elongation

Buttle, David J.; Pitsillides, Andrew A.; Staines, Katherine A.; Javaheri, Behzad; Hohenstein, Peter; Fleming, Robert; Ikpegbu, Ekele; Unger, Erin; Hopkinson, Mark; Buttle, David; Pitsillides, Andrew; Farquharson, Colin

Authors

David J. Buttle

Andrew A. Pitsillides

Katherine A. Staines

Behzad Javaheri

Peter Hohenstein

Robert Fleming

Ekele Ikpegbu

Erin Unger

Mark Hopkinson

David Buttle

Andrew Pitsillides

Colin Farquharson



Abstract

The transmembrane glycoprotein E11/Podoplanin (Pdpn) has been implicated in the initial stages of osteocyte differentiation. However, its precise function and regulatory mechanisms are still unknown. Due to the known embryonic lethality induced by global Pdpn deletion, we have herein explored the effect of bone specific Pdpn knockdown on osteocyte form and function in the post-natal mouse. Extensive skeletal phenotyping of male and female 6-week-old Oc-cre;Pdpnflox/flox (cKO) mice and their Pdpnflox/flox controls (fl/fl) has revealed that Pdpn deletion significantly compromises tibial cortical bone microarchitecture in both sexes, albeit to different extents (P

Journal Article Type Article
Acceptance Date May 8, 2017
Online Publication Date May 10, 2017
Publication Date 2017-11
Deposit Date May 8, 2017
Publicly Available Date Nov 2, 2017
Journal Journal of Cellular Physiology
Print ISSN 0021-9541
Publisher Wiley
Peer Reviewed Peer Reviewed
Volume 232
Issue 11
Pages 3006-3019
DOI https://doi.org/10.1002/jcp.25999
Keywords Osteocytes; E11; osteocalcin; osteoblasts; dendrite
Public URL http://researchrepository.napier.ac.uk/Output/841066
Contract Date Nov 2, 2017

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