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The lived experience of interferon-free treatments for hepatitis C: A thematic analysis

Whiteley, David; Whittaker, Anne; Elliott, Lawrie; Cunningham-Burley, Sarah


David Whiteley

Anne Whittaker

Lawrie Elliott

Sarah Cunningham-Burley


Background: International discourse concerning the evolution in hepatitis C virus (HCV) therapy has tended to focus on improving outcomes, shortened treatment length and reduced side-effects of interferon-free regimens. How these treatments are being understood and experienced by the people receiving them has so far been overlooked. This study therefore aimed to explore the lived experience of individuals taking interferon-free HCV therapies. Methods: Data were generated through 16 semi-structured interviews with a purposive sample of eight participants, recruited from a university hospital in Scotland. The interviews took place between June 2015 and March 2016, before and after a period of interferon-free HCV treatment. The data were interrogated using a thematic analysis, underpinned by social phenomenological theory. Results: Three overriding themes were identified. 'Expectations and realisations' characterised the influence that interferon continued to cast over interferon-free treatment, contrasting the practicalities of taking interferon-free therapy with preconceived notions. 'An honour and a pleasure' portrayed a positive experience of an undemanding therapy, yet among those with a history of drug use, was also positioned as a privilege, associated with feelings of luck and guilt. 'Treatment needs' illustrated the strategies participants used to search for treatment efficacy, and the value those with a significant history of drug use placed on support. One nonconforming case is then discussed to enhance rigour and trustworthiness. Conclusion: This is the first qualitative exploration of the experience of interferon-free HCV treatment reported globally. The results from this study suggest a cultural lag exists between the pharmacological developments which have been witnessed, and societal understandings of them. This has implications for the way services meet the needs of, and offer therapy to, HCV positive individuals

Journal Article Type Article
Acceptance Date Oct 19, 2016
Online Publication Date Nov 11, 2016
Publication Date 2016-12
Deposit Date Nov 17, 2016
Publicly Available Date Nov 12, 2017
Journal International Journal of Drug Policy
Print ISSN 0955-3959
Publisher Elsevier
Peer Reviewed Peer Reviewed
Volume 38
Pages 21-28
Keywords antiviral agents; hepatitis C; interferon-free; lived experience; qualitative research; therapeutics
Public URL
Contract Date Nov 17, 2016


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