The influence of resistance training on neuromuscular function in middle-aged and older adults: A systematic review and meta-analysis of randomised controlled trials.

James, Emily; Nichols, Simon; Goodall, Stuart; Hicks, Kirsty M; O'doherty, Alasdair F

Abstract

Background: Deterioration of neuromuscular function is a major mechanism of age-related strength loss. Resistance training (RT) improves muscle strength and mass. However, the effects of RT on neuromuscular adaptations in middle-aged and older adults are unclear. Methods: Randomised controlled RT interventions (≥2 weeks) involving adults aged ≥50 years were identified. Primary outcome measures were voluntary activation (VA), electromyographic (EMG) activity during maximal voluntary contraction (MVC), and antagonist coactivation. Data were pooled using a weighted random-effect model. Sub-analyses were conducted by muscle or muscle group and health status of participants. Sensitivity analysis was based on study quality. P < 0.05 indicated statistical significance. Results: Twenty-seven studies were included. An effect was found for VA (standardised mean difference [SMD] 0.54, 0.01 to 1.07, P = 0.04), This result remained significant following sensitivity analysis involving only studies that were low risk of bias. Subgroup analyses showed an effect for plantar flexor VA (SMD 1.13, 0.20 to 2.06, P = 0.02) and VA in healthy participants (SMD 1.04, 0.32 to 1.76, P = 0.004). There was no effect for EMG activity or antagonist coactivation of any muscle group (P > 0.05). Discussion: Resistance training did not alter EMG activity or antagonist coactivation in older adults. Sensitivity analysis resulted in the effect for VA remaining significant, indicating that this finding was not dependent on study quality. Studies predominantly involved healthy older adults (78%), limiting the generalisability of these findings to clinical cohorts. Future research should determine the effects of RT on neuromuscular function in people with sarcopenia and age-related syndromes.

Citation

James, E., Nichols, S., Goodall, S., Hicks, K. M., & O'doherty, A. F. (2021). The influence of resistance training on neuromuscular function in middle-aged and older adults: A systematic review and meta-analysis of randomised controlled trials. Experimental Gerontology, 149, Article 111320. https://doi.org/10.1016/j.exger.2021.111320

• Journal Article Type: Article
• Acceptance Date: Mar 18, 2021
• Online Publication Date: Mar 24, 2021
• Publication Date: 2021-07
• Deposit Date: Oct 21, 2024
• Publicly Available Date: Oct 21, 2024
• Journal: Experimental Gerontology
• Print ISSN: 0531-5565
• Publisher: Elsevier
• Peer Reviewed: Peer Reviewed
• Volume: 149
• Article Number: 111320
• DOI: https://doi.org/10.1016/j.exger.2021.111320
• Keywords: Ageing, Resistance training, Neuromuscular, Muscle activation