The assessment of paraspinal muscle epimuscular fat in participants with and without low back pain: A case-control study

Rosenstein, Brent; Burdick, Jessica; Roussac, Alexa; Rye, Meaghan; Naghdi, Neda; Valentin, Stephanie; Licka, Theresia; Sean, Monica; Tétreault, Pascal; Elliott, Jim; Fortin, Maryse

Abstract

It remains unclear whether paraspinal muscle fatty infiltration in low back pain (LBP) is i) solely intramuscular, ii) is lying outside the epimysium between the muscle and fascial plane (epimuscular) or iii) or combination of both, as imaging studies often use different segmentation protocols that are not thoroughly described. Epimuscular fat possibly disturbs force generation of paraspinal muscles, but is seldomly explored. This project aimed to 1) compare epimuscular fat in participants with and without chronic LBP, and 2) determine whether epimuscular fat is different across lumbar spinal levels and associated with BMI, age, sex and LBP status, duration or intensity. Fat and water lumbosacral MRIs of 50 chronic LBP participants and 41 healthy controls were used. The presence and extent of epimuscular fat for the paraspinal muscle group (erector spinae and multifidus) was assessed using a qualitative score (0–5 scale; 0 = no epimuscular fat and 5 = epimuscular fat present along the entire muscle) and quantitative manual segmentation method. Chi-squared tests evaluated associations between qualitative epimuscular fat ratings and LBP status at each lumbar level. Bivariate and partial spearman’s rho correlation assessed relationships between quantitative and qualitative epimuscular fat with participants’ characteristics. Epimuscular fat was more frequent at the L4-L5 (X2 = 13.781, p = 0.017) and L5-S1 level (X2 = 27.825, p < 0.001) in participants with LBP compared to controls, which was not found for the higher lumbar levels. The total qualitative score (combined from all levels) showed a significant positive correlation with BMI, age, sex (female) and LBP status (r = 0.23–0.55; p < 0.05). Similarly, the total area of epimuscular fat (quantitative measure) was significantly correlated with BMI, age and LBP status (r = 0.26–0.57; p < 0.05). No correlations were found between epimuscular fat and LBP duration or intensity. Paraspinal muscle epimuscular fat is more common in chronic LBP patients. The functional implications of epimuscular fat should be further explored.

Citation

Rosenstein, B., Burdick, J., Roussac, A., Rye, M., Naghdi, N., Valentin, S., Licka, T., Sean, M., Tétreault, P., Elliott, J., & Fortin, M. (2024). The assessment of paraspinal muscle epimuscular fat in participants with and without low back pain: A case-control study. Journal of Biomechanics, 163, Article 111928. https://doi.org/10.1016/j.jbiomech.2024.111928

• Journal Article Type: Article
• Acceptance Date: Jan 3, 2024
• Online Publication Date: Jan 10, 2024
• Publication Date: 2024-01
• Deposit Date: Mar 22, 2024
• Publicly Available Date: Mar 22, 2024
• Journal: Journal of Biomechanics
• Print ISSN: 0021-9290
• Publisher: Elsevier
• Peer Reviewed: Peer Reviewed
• Volume: 163
• Article Number: 111928
• DOI: https://doi.org/10.1016/j.jbiomech.2024.111928
• Keywords: Low back pain, Magnetic resonance imaging, Paraspinal muscles, Epimuscular fat
• Public URL: http://researchrepository.napier.ac.uk/Output/3573342