Rheometrical Studies of Blood Clot Formation by Oscillatory Shear, Thromboelastography, Sonoclot Analysis and Free Oscillation Rheometry

Evans, P Adrian; Hawkins, Karl M; Lawrence, Matthew J; Williams, P Rhodri; Williams, Rhodri L

Abstract

We report studies of the coagulation of samples of whole human blood by oscillatory shear techniques, including Fourier Transform Mechanical Spectroscopy (FTMS). These techniques are used herein to identify the Gel Point of coagulating blood in terms of the Chambon‐Winter Gel Point criterion which provides a rheometrical basis for detecting the establishment of an incipient clot. A comparison of the results of FTMS with those obtained from measurements involving a Thromboelastograph (TEG), a Sonoclot Analyzer and a Free Oscillation Rheometer (FOR) indicate that the latter techniques are not capable of detecting the incipient clot, whose establishment occurs several minutes prior to TEG or FOR‐based assessments of clot formation time. The results of the present study suggest that FTMS is a useful tool in blood clotting research, being capable of providing a global coagulation profile in addition to detecting the instant of incipient clot formation.

Citation

Evans, P. A., Hawkins, K. M., Lawrence, M. J., Williams, P. R., & Williams, R. L. (2008). Rheometrical Studies of Blood Clot Formation by Oscillatory Shear, Thromboelastography, Sonoclot Analysis and Free Oscillation Rheometry. AIP conference proceedings, https://doi.org/10.1063/1.2964777

• Journal Article Type: Conference Paper
• Acceptance Date: Jan 1, 2008
• Publication Date: 2008
• Deposit Date: Jul 27, 2016
• Journal: AIP Conference Proceedings
• Print ISSN: 0094-243X
• Electronic ISSN: 0094-243X
• Publisher: AIP Publishing
• Peer Reviewed: Peer Reviewed
• DOI: https://doi.org/10.1063/1.2964777
• Keywords: Free oscillations, Fourier transform mass spectrometry, Gels, Fourier transform spectroscopy, Rheometry
• Public URL: http://researchrepository.napier.ac.uk/Output/317938