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An enduring in vitro wound healing phase recipient by bioactive glass-graphene oxide nanocomposites

Nandhakumar, Manjubaashini; Thangaian, Daniel Thangadurai; Sundaram, Senthilarasu; Roy, Anurag; Subramanian, Balakumar


Manjubaashini Nandhakumar

Daniel Thangadurai Thangaian

Anurag Roy

Balakumar Subramanian


Bioactive glass (BG) is an interesting topic in soft tissue engineering because of its biocompatibility and bonding potential to increase fibroblast cell proliferation, synthesize growth factors, and stimulate granulation tissue development. The proposed BG with and without sodium (Na), prepared by the sol–gel method, is employed in wound healing studies. The BG/graphene oxide (GO) and BG (Na-free)/GO nanocomposites were investigated against fibroblast L929 cells in vitro; the 45S5 BG nanocomposites exhibited desired cell viability (80%), cell proliferation (30%), cell migration (25%), metabolic activity, and wound contraction due to extracellular matrix (ECM) production and enhanced protein release by fibroblast cells. Additionally, the antioxidant assays for BG, BG (Na-free), GO, and BG/GO, BG (Na-free)/GO were evaluated for effective wound healing properties. The results showed decreased inflammation sites in the wound area, assessed by the (2,2-diphenyl-1-picryl-hydrazyl-hydrate) (DPPH) assay with ~ 80% radical scavenging activity, confirming their anti-inflammatory and improved wound healing properties.

Journal Article Type Article
Acceptance Date Sep 15, 2022
Online Publication Date Sep 28, 2022
Publication Date 2022
Deposit Date Oct 5, 2022
Publicly Available Date Oct 5, 2022
Journal Scientific Reports
Publisher Nature Publishing Group
Peer Reviewed Peer Reviewed
Volume 12
Issue 1
Article Number 16162
Public URL


An enduring in vitro wound healing phase recipient by bioactive glass-graphene oxide nanocomposites (7.4 Mb)

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Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made.

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