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Co-optimization method to improve lateral resolution in photoacoustic computed tomography

Zhang, Yang; Yang, Shufan; Xia, Zhiying; Hou, Ruijie; Xu, Bin; Hou, Lianping; Marsh, John H.; Jiangmin Hou, Jamie; Mojtaba Rezaei Sani, Seyed; Liu, Xuefeng; Xiong, Jichuan


Yang Zhang

Zhiying Xia

Ruijie Hou

Bin Xu

Lianping Hou

John H. Marsh

Jamie Jiangmin Hou

Seyed Mojtaba Rezaei Sani

Xuefeng Liu

Jichuan Xiong


In biomedical imaging, photoacoustic computed tomography (PACT) has recently gained increased interest as this imaging technique has good optical contrast and depth of acoustic penetration. However, a spinning blur will be introduced during the image reconstruction process due to the limited size of the ultrasonic transducers (UT) and a discontinuous measurement process. In this study, a damping UT and adaptive back-projection co-optimization (CODA) method is developed to improve the lateral spatial resolution of PACT. In our PACT system, a damping aperture UT controls the size of the receiving area, which suppresses image blur at the signal acquisition stage. Then, an innovative adaptive back-projection algorithm is developed, which corrects the undesirable artifacts. The proposed method was evaluated using agar phantom and ex-vivo experiments. The results show that the CODA method can effectively compensate for the spinning blur and eliminate unwanted artifacts in PACT. The proposed method can significantly improve the lateral spatial resolution and image quality of reconstructed images, making it more appealing for wider clinical applications of PACT as a novel, cost-effective modality.


Zhang, Y., Yang, S., Xia, Z., Hou, R., Xu, B., Hou, L., …Xiong, J. (2022). Co-optimization method to improve lateral resolution in photoacoustic computed tomography. Biomedical Optics Express, 13(9), 4621-4636.

Journal Article Type Article
Acceptance Date Aug 2, 2022
Online Publication Date Aug 9, 2022
Publication Date 2022-09
Deposit Date Aug 5, 2022
Publicly Available Date Aug 9, 2022
Publisher Optical Society of America
Peer Reviewed Peer Reviewed
Volume 13
Issue 9
Pages 4621-4636
Public URL


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