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Mindfulness-based interventions for non-affective psychosis: A comprehensive systematic review and meta-analysis

Lai King Yip, Annie; Karatzias, Thanos; Tong Chien, Wai


Wai Tong Chien


Aim: Although mindfulness-based interventions (MBIs) are routinely used in clinical practice, a comprehensive synthesis of the effectiveness of MBIs for non-affective psychosis has yet to be conducted. The aim in the present review and meta-analysis was to investigate the effectiveness of MBIs including those with mindfulness as an active treatment component at alleviating symptoms of psychosis to inform future clinical practice.
Methods: A systematic review of studies published in journals or in dissertations in CINAHL, PubMed, EMBASE, PsycINFO, CENTRAL, ISRCTN or CNKI from January 1990 until December 2020. A total of 31 eligible studies (n=2,146) were included.
Results: Effect-size estimates suggested that 22 independent samples (n=1,632) produced a statistically significant small effect for psychotic symptoms (g=-0.48), and with a clinically significant reduction of 50% from baseline (pooled OR: 1.84). Separate meta-analyses demonstrated small effects for affective symptoms (g=-0.44) and small-to-large positive effects for quality of life (g=0.38), mindfulness skills (g=0.45), and insight into illness/treatment (g=1.35). The heterogeneity was high across the studies.
Conclusion: Results suggest that short-term MBIs can be beneficial for non-affective psychosis. Future research is needed to test the efficacy and safety of dedicated MBIs for this population group over a longer-term.


Lai King Yip, A., Karatzias, T., & Tong Chien, W. (2022). Mindfulness-based interventions for non-affective psychosis: A comprehensive systematic review and meta-analysis. Annals of Medicine, 54(1), 2340-2353.

Journal Article Type Article
Acceptance Date Jul 29, 2022
Online Publication Date Aug 25, 2022
Publication Date 2022
Deposit Date Aug 5, 2022
Publicly Available Date Aug 25, 2022
Journal Annals of Medicine
Print ISSN 0785-3890
Electronic ISSN 1365-2060
Publisher Taylor and Francis
Peer Reviewed Peer Reviewed
Volume 54
Issue 1
Pages 2340-2353
Public URL


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