A Better Disinfectant for Low-Resourced Hospitals? A Multi-Period Cluster Randomised Trial Comparing Hypochlorous Acid with Sodium Hypochlorite in Nigerian Hospitals: The EWASH Trial

Gon, Giorgia; Dansero, Lucia; Aiken, Alexander M.; Bottomley, Christian; Dancer, Stephanie J.; Graham, Wendy J.; Ike, Olivia C.; Lewis, Michelle; Meakin, Nick; Okafor, Obiora; Uwaezuoke, Nkolika S.; Okwor, Tochi Joy

Abstract

Environmental hygiene in hospitals is a major challenge worldwide. Low-resourced hospitals in African countries continue to rely on sodium hypochlorite (NaOCl) as major disinfectant. However, NaOCl has several limitations such as the need for daily dilution, irritation, and corrosion. Hypochlorous acid (HOCl) is an innovative surface disinfectant produced by saline electrolysis with a much higher safety profile. We assessed non-inferiority of HOCl against standard NaOCl for surface disinfection in two hospitals in Abuja, Nigeria using a double-blind multi-period randomised cross-over study. Microbiological cleanliness [Aerobic Colony Counts (ACC)] was measured using dipslides. We aggregated data at the cluster-period level and fitted a linear regression. Microbiological cleanliness was high for both disinfectant (84.8% HOCl; 87.3% NaOCl). No evidence of a significant difference between the two products was found (RD = 2%, 90%CI: −5.1%–+0.4%; p-value = 0.163). We cannot rule out the possibility of HOCl being inferior by up to 5.1 percentage points and hence we did not strictly meet the non-inferiority margin we set ourselves. However, even a maximum difference of 5.1% in favour of sodium hypochlorite would not suggest there is a clinically relevant difference between the two products. We demonstrated that HOCl and NaOCl have a similar efficacy in achieving microbiological cleanliness, with HOCl acting at a lower concentration. With a better safety profile, and potential applicability across many healthcare uses, HOCl provides an attractive and potentially cost-efficient alternative to sodium hypochlorite in low resource settings.

Citation

Gon, G., Dansero, L., Aiken, A. M., Bottomley, C., Dancer, S. J., Graham, W. J., Ike, O. C., Lewis, M., Meakin, N., Okafor, O., Uwaezuoke, N. S., & Okwor, T. J. (2022). A Better Disinfectant for Low-Resourced Hospitals? A Multi-Period Cluster Randomised Trial Comparing Hypochlorous Acid with Sodium Hypochlorite in Nigerian Hospitals: The EWASH Trial. Microorganisms, 10(5), Article 910. https://doi.org/10.3390/microorganisms10050910

• Journal Article Type: Article
• Acceptance Date: Apr 13, 2022
• Online Publication Date: Apr 26, 2022
• Publication Date: 2022
• Deposit Date: May 23, 2022
• Publicly Available Date: May 23, 2022
• Publisher: MDPI
• Peer Reviewed: Peer Reviewed
• Volume: 10
• Issue: 5
• Article Number: 910
• DOI: https://doi.org/10.3390/microorganisms10050910
• Keywords: hypochlorous acid; disinfectant; hospital; environmental hygiene; Nigeria
• Public URL: http://researchrepository.napier.ac.uk/Output/2873411