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Narrative review of closed loop automated oxygen systems

Stewart, Lyndsey; MacVicar, Sonya


Lyndsey Stewart


Preterm infants frequently require respiratory support with supplemental oxygen but excess and fluctuation of oxygen levels can have adverse effects. Oxygen saturation levels are maintained within narrow target ranges as a manual titration process. Closed loop automated oxygen systems hypothesis that automatic titration of inspired oxygen will reduce time spent out of desired oxygen target range compared with current manual control.

comparison of automated versus manual oxygen control for preterm neonates undergoing non-invasive ventilation plus supplemental oxygen.

Four electronic databases (CINAHL, Cochrane Library, Medline and PubMed) were searched with narrative review of findings.

Four studies were included and all reported neonates spent more time in the oxygen target range with automated versus manual control with a wide variation in improvement from 8.8% to 30%.

Automated oxygen systems with non-invasive respiratory modalities can minimise time spent out with oxygen target range. Long term impact of automated control on incidence of oxidative stress injury remains undetermined.

Journal Article Type Article
Acceptance Date May 3, 2022
Online Publication Date May 11, 2022
Publication Date 2023-04
Deposit Date May 16, 2022
Publicly Available Date May 16, 2022
Journal Journal of Neonatal Nursing
Print ISSN 1355-1841
Publisher Elsevier
Peer Reviewed Peer Reviewed
Volume 29
Issue 2
Pages 229-234
Keywords Narrative review, Closed loop automated oxygen system, CLAOS’ prematurity neonate, Non-invasive respiratory support, Supplementary oxygen, Oxygen saturation
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