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Exercise for individuals with bone metastases: A systematic review

Weller, Sarah; Hart, Nicolas H.; Bolam, Kate A.; Mansfield, Sami; Santa Mina, Daniel; Winters-Stone, Kerri M.; Campbell, Anna; Rosenberger, Friederike; Wiskemann, Joachim; Quist, Morten; Cormie, Prue; Goulart, Jennifer; Campbell, Kristin L.


Sarah Weller

Nicolas H. Hart

Kate A. Bolam

Sami Mansfield

Daniel Santa Mina

Kerri M. Winters-Stone

Friederike Rosenberger

Joachim Wiskemann

Morten Quist

Prue Cormie

Jennifer Goulart

Kristin L. Campbell


Exercise has the potential to improve physical function and quality of life in individuals with bone metastases but is often avoided due to safety concerns. This systematic review summarizes the safety, feasibility and efficacy of exercise in controlled trials that include individuals with bone metastases.

MEDLINE, Embase, Pubmed, CINAHL, PEDro and CENTRAL databases were searched up to July 16, 2020.

A total of 17 trials were included incorporating aerobic exercise, resistance exercise or soccer interventions. Few (n=4, 0.5%) serious adverse events were attributed to exercise participation, with none related to bone metastases. Mixed efficacy results were found, with exercise eliciting positive changes or no change. The majority of trials included an element of supervised exercise instruction (n=16, 94%) and were delivered by qualified exercise professionals (n=13, 76%).

Exercise appears safe and feasible for individuals with bone metastases when it includes an element of supervised exercise instruction.

Journal Article Type Article
Acceptance Date Jul 28, 2021
Online Publication Date Aug 3, 2021
Publication Date 2021-10
Deposit Date Jul 30, 2021
Publicly Available Date Aug 4, 2022
Journal Critical Reviews in Oncology/Hematology
Print ISSN 1040-8428
Publisher Elsevier
Peer Reviewed Peer Reviewed
Volume 166
Article Number 103433
Keywords neoplasm metastasis; bone neoplasms; neoplasms; rehabilitation; Exercise; sports; systematic review
Public URL


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