Investigating the impact of a spinal mobilisation intervention in people with multiple sclerosis

Hamilton, Rebecca Isabel

Abstract

Background: Multiple Sclerosis (MS) has many disabling symptoms due to weakened signal propagation in the central nervous system. Manual therapeutics are often seen to have a positive effect on these symptoms with limited information as to why. The purpose of this project was to investigate a spinal mobilisation intervention, objectively measuring the changes it may be causing to muscle quality and movement patterns as a contribution to research in MS therapeutics.
Methods: A series of 3 studies were designed to investigate the effects of a spinal mobilisation intervention on muscle quality and movement patterns. Study 1 tested people with lower back pain (LBP) as a pilot population (n=40), testing for an immediate effect on muscle quality. Study 2 replicated this with MS patients (n=20) assessing muscle quality, balance, and pain. Study 3 tested the intervention in a longer-term 4 bout study (n=20), assessing muscle quality, balance, pain, and fatigue.
Results: Significant muscle stiffness reductions were seen in the LBP population post the intervention (p = 0.01, η2partial = 0.15). Baseline stiffness was found as a significant contributor (p = 0.002, R2 = 0.22). These muscular results were not replicated with the MS population. However, significant improvements in self-reported pain as a result of the intervention were revealed (p = 0.008, η2partial = 0.33). Study 3 findings demonstrated significant improvements from baseline in balance and fatigue measures as a result of the intervention. High variability in the data are seen within the MS population.
Conclusions: Four sessions were not sufficient to elicit a significant response in muscle quality as a result of the intervention in an MS population. However, significant improvements in balance and fatigue were revealed. Given the variability from the MS population, it is necessary to undertake a longer-term study and normalise baseline muscle quality values.

Citation

Hamilton, R. I. Investigating the impact of a spinal mobilisation intervention in people with multiple sclerosis. (Thesis). Edinburgh Napier University. Retrieved from http://researchrepository.napier.ac.uk/Output/2709099

• Thesis Type: Thesis
• Deposit Date: Dec 7, 2020
• Publicly Available Date: Dec 7, 2020
• DOI: https://doi.org/10.17869/enu.2020.2709099
• Keywords: Multiple Sclerosis (MS); spinal mobilisation intervention; muscle quality; movement patterns; therapeutics
• Public URL: http://researchrepository.napier.ac.uk/Output/2709099
• Award Date: Oct 5, 2020