Chris McEwan
Revisiting the Central and Peripheral Immune System
McEwan, Chris; Hart, Emma; Paechter, Ben
Authors
Abstract
The idiotypic network has a long and chequered history in both theoretical immunology and Artificial Immune Systems. In terms of the latter, the drive for engineering applications has led to a diluted interpretation of the immunological models. Research inspired by theoretical immunology has produced compelling models of self-organised tolerance and immunity, but currently fail to have any practical engineering applicability. In this paper, we briefly discuss the engineering applicability of “self-affirming” idiotypic networks, leading to a suggestion that the “Third Generation” network models represent a way forward in this respect. Results obtained by implementing and extending a discrete model of this type of network suggest that the extended prototype is capable of two context-dependent modes of immune response, readily applicable to unsupervised machine-learning.
Citation
McEwan, C., Hart, E., & Paechter, B. (2007, August). Revisiting the Central and Peripheral Immune System. Presented at ICARIS 2007: International Conference on Artificial Immune Systems, Santos, Brazil
Presentation Conference Type | Conference Paper (published) |
---|---|
Conference Name | ICARIS 2007: International Conference on Artificial Immune Systems |
Start Date | Aug 26, 2007 |
End Date | Aug 29, 2007 |
Publication Date | 2007 |
Deposit Date | Mar 15, 2010 |
Electronic ISSN | 1611-3349 |
Publisher | Springer |
Peer Reviewed | Peer Reviewed |
Pages | 240-251 |
Series Title | Lecture Notes in Computer Science |
Series Number | 4628 |
Series ISSN | 0302-9743 |
Book Title | Artificial Immune Systems. ICARIS 2007 |
ISBN | 9783540739210 |
DOI | https://doi.org/10.1007/978-3-540-73922-7_21 |
Keywords | Artificial immune systems; theoretical immunology; “self-affirming” idiotypic networks; “Third Generation” network; |
Public URL | http://researchrepository.napier.ac.uk/id/eprint/3436 |
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