Revisiting the Central and Peripheral Immune System

McEwan, Chris; Hart, Emma; Paechter, Ben

Abstract

The idiotypic network has a long and chequered history in both theoretical immunology and Artificial Immune Systems. In terms of the latter, the drive for engineering applications has led to a diluted interpretation of the immunological models. Research inspired by theoretical immunology has produced compelling models of self-organised tolerance and immunity, but currently fail to have any practical engineering applicability. In this paper, we briefly discuss the engineering applicability of “self-affirming” idiotypic networks, leading to a suggestion that the “Third Generation” network models represent a way forward in this respect. Results obtained by implementing and extending a discrete model of this type of network suggest that the extended prototype is capable of two context-dependent modes of immune response, readily applicable to unsupervised machine-learning.

Citation

McEwan, C., Hart, E., & Paechter, B. (2007, August). Revisiting the Central and Peripheral Immune System. Presented at ICARIS 2007: International Conference on Artificial Immune Systems, Santos, Brazil

• Presentation Conference Type: Conference Paper (published)
• Conference Name: ICARIS 2007: International Conference on Artificial Immune Systems
• Start Date: Aug 26, 2007
• End Date: Aug 29, 2007
• Publication Date: 2007
• Deposit Date: Mar 15, 2010
• Electronic ISSN: 1611-3349
• Publisher: Springer
• Peer Reviewed: Peer Reviewed
• Pages: 240-251
• Series Title: Lecture Notes in Computer Science
• Series Number: 4628
• Series ISSN: 0302-9743
• Book Title: Artificial Immune Systems. ICARIS 2007
• ISBN: 9783540739210
• DOI: https://doi.org/10.1007/978-3-540-73922-7_21
• Keywords: Artificial immune systems; theoretical immunology; “self-affirming” idiotypic networks; “Third Generation” network
• Public URL: http://researchrepository.napier.ac.uk/id/eprint/3436