Albert Tenesa
Genome-wide association scan identifies a colorectal cancer susceptibility locus on 11q23 and replicates risk loci at 8q24 and 18q21
Tenesa, Albert; Farrington, Susan M; Prendergast, James G D; Porteous, Mary E; Walker, Marion; Haq, Naila; Barnetson, Rebecca A; Theodoratou, Evropi; Cetnarskyj, Roseanne; Cartwright, Nicola; Semple, Colin; Clark, Andrew J; Reid, Fiona J L; Smith, Lorna A; Kavoussanakis, Kostas; Koessler, Thibaud; Pharoah, Paul D P; Buch, Stephan; Schafmayer, Clemens; Tepel, J?rgen; Schreiber, Stefan; V?lzke, Henry; Schmidt, Carsten O; Hampe, Jochen; Chang-Claude, Jenny; Hoffmeister, Michael; Brenner, Hermann; Wilkening, Stefan; Canzian, Federico; Capella, Gabriel; Moreno, Victor; Deary, Ian J; Starr, John M; Tomlinson, Ian P M; Kemp, Zoe; Howarth, Kimberley; Carvajal-Carmona, Luis; Webb, Emily; Broderick, Peter; Vijayakrishnan, Jayaram; Houlston, Richard S; Rennert, Gad; Ballinger, Dennis; Rozek, Laura; Gruber, Stephen B; Matsuda, Koichi; Kidokoro, Tomohide; Nakamura, Yusuke; Zanke, Brent W; Greenwood, Celia M T; Rangrej, Jagadish; Kustra, Rafal; Montpetit, Alexandre; Hudson, Thomas J; Gallinger, Stev...
Authors
Susan M Farrington
James G D Prendergast
Mary E Porteous
Marion Walker
Naila Haq
Rebecca A Barnetson
Evropi Theodoratou
Roseanne Cetnarskyj
Nicola Cartwright
Colin Semple
Andrew J Clark
Fiona J L Reid
Lorna A Smith
Kostas Kavoussanakis
Thibaud Koessler
Paul D P Pharoah
Stephan Buch
Clemens Schafmayer
Tepel
Stefan Schreiber
Henry
Carsten O Schmidt
Jochen Hampe
Jenny Chang-Claude
Michael Hoffmeister
Hermann Brenner
Stefan Wilkening
Federico Canzian
Gabriel Capella
Victor Moreno
Ian J Deary
John M Starr
Ian P M Tomlinson
Zoe Kemp
Kimberley Howarth
Luis Carvajal-Carmona
Emily Webb
Peter Broderick
Jayaram Vijayakrishnan
Richard S Houlston
Gad Rennert
Dennis Ballinger
Laura Rozek
Stephen B Gruber
Koichi Matsuda
Tomohide Kidokoro
Yusuke Nakamura
Brent W Zanke
Celia M T Greenwood
Jagadish Rangrej
Rafal Kustra
Alexandre Montpetit
Thomas J Hudson
Steven Gallinger
Harry Campbell
Malcolm G Dunlop
Abstract
In a genome-wide association study to identify loci associated with colorectal cancer (CRC) risk, we genotyped 555,510 SNPs in 1,012 early-onset Scottish CRC cases and 1,012 controls (phase 1). In phase 2, we genotyped the 15,008 highest-ranked SNPs in 2,057 Scottish cases and 2,111 controls. We then genotyped the five highest-ranked SNPs from the joint phase 1 and 2 analysis in 14,500 cases and 13,294 controls from seven populations, and identified a previously unreported association, rs3802842 on 11q23 (OR = 1.1; P = 5.8 10-10), showing population differences in risk. We also replicated and fine-mapped associations at 8q24 (rs7014346; OR = 1.19; P = 8.6 10-26) and 18q21 (rs4939827; OR = 1.2; P = 7.8 10-28). Risk was greater for rectal than for colon cancer for rs3802842 (P < 0.008) and rs4939827 (P < 0.009). Carrying all six possible risk alleles yielded OR = 2.6 (95% CI = 1.75–3.89) for CRC. These findings extend our understanding of the role of common genetic variation in CRC etiology.
Citation
Tenesa, A., Farrington, S. M., Prendergast, J. G. D., Porteous, M. E., Walker, M., Haq, N., …Dunlop, M. G. (2008). Genome-wide association scan identifies a colorectal cancer susceptibility locus on 11q23 and replicates risk loci at 8q24 and 18q21. Nature Genetics, 40, 631-637. https://doi.org/10.1038/ng.133
Journal Article Type | Article |
---|---|
Publication Date | 2008 |
Deposit Date | Mar 13, 2014 |
Print ISSN | 1061-4036 |
Electronic ISSN | 1546-1718 |
Publisher | Nature Publishing Group |
Peer Reviewed | Peer Reviewed |
Volume | 40 |
Pages | 631-637 |
DOI | https://doi.org/10.1038/ng.133 |
Keywords | Colorectal cancer; genetic variation; CRC etiology; |
Public URL | http://researchrepository.napier.ac.uk/id/eprint/6616 |
Publisher URL | http://dx.doi.org/10.1038/ng.133 |
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