Dendritic cell trafficking: from Immunology to Engineering.

Hart, Emma; Davoudani, Despina

Abstract

The field of Artificial Immune Systems (AIS) has derived inspiration from many different elements of the natural immune system in order to develop engineered systems that operate in environments with constraints similar to those faced by the immune system [1]. A recent shift in thinking in AIS advocates developing a greater understanding of the underlying biological systems that serve as inspiration for engineering such systems by developing abstract computational models of the immune system in order to better understand the natural biology [2]. In this paper, we present results from a study in which agent-based modelling techniques were used to construct a model of dendritic-cell trafficking in the natural immune system with the aim of translating this model to an engineered system: a large-scale wireless sensor network. Our results highlight some generic issues which may arise when modelling biology with the intention of applying the results to AIS, rather than when modelling in order to replicate observed biological data. We suggest that the constraints of the engineered system must be considered when iterating the model, and that certain aspects of the biology may not be appropriate for the engineered system in question

Citation

Hart, E., & Davoudani, D. (2009, August). Dendritic cell trafficking: from Immunology to Engineering. Presented at 8th International Conference, ICARIS 2009, York, UK

• Presentation Conference Type: Conference Paper (published)
• Conference Name: 8th International Conference, ICARIS 2009
• Start Date: Aug 9, 2009
• End Date: Aug 12, 2009
• Publication Date: 2009-08
• Deposit Date: Jan 29, 2010
• Publisher: Springer
• Peer Reviewed: Peer Reviewed
• Volume: 5666
• Pages: 11-13
• Series Title: Lecture Notes in Computer Science
• Series Number: 5666
• Series ISSN: 0302-9743
• Book Title: Artificial Immune Systems
• ISBN: 978-3-642-03245-5
• DOI: https://doi.org/10.1007/978-3-642-03246-2_4
• Keywords: Artificial immune systems; AIS; immune systems; agent-based modelling techniques; dendritic-cell trafficking; wireless sensor network
• Public URL: http://researchrepository.napier.ac.uk/id/eprint/3479
• Publisher URL: https://doi.org/10.1007/978-3-642-03246-2_4