Karin S�rig Hougaard
A perspective on the developmental toxicity of inhaled nanoparticles
Hougaard, Karin S�rig; Campagnolo, Luisa; Chavatte-Palmer, Pascale; Tarrade, Anne; Rousseau-Ralliard, Delphine; Valentino, Sarah; Park, Margriet V D Z; de Jong, Wim H; Wolterink, Gerrit; Piersma, Aldert H; Ross, Bryony L; Hutchison, Gary R; Hansen, Jitka Stilund; Vogel, Ulla; Jackson, Petra; Slama, R�my; Pietroiusti, Antonio; Cassee, Flemming R
Authors
Luisa Campagnolo
Pascale Chavatte-Palmer
Anne Tarrade
Delphine Rousseau-Ralliard
Sarah Valentino
Margriet V D Z Park
Wim H de Jong
Gerrit Wolterink
Aldert H Piersma
Bryony L Ross
Prof Gary Hutchison Ga.Hutchison@napier.ac.uk
Dean of Applied Sciences
Jitka Stilund Hansen
Ulla Vogel
Petra Jackson
R�my Slama
Antonio Pietroiusti
Flemming R Cassee
Abstract
This paper aimed to clarify whether maternal inhalation of engineered nanoparticles (NP) may constitute a hazard to pregnancy and fetal development, primarily based on experimental animal studies of NP and air pollution particles. Overall, it is plausible that NP may translocate from the respiratory tract to the placenta and fetus, but also that adverse effects may occur secondarily to maternal inflammatory responses. The limited database describes several organ systems in the offspring to be potentially sensitive to maternal inhalation of particles, but large uncertainties exist about the implications for embryo–fetal development and health later in life. Clearly, the potential for hazard remains to be characterized. Considering the increased production and application of nanomaterials and related consumer products a testing strategy for NP should be established. Due to large gaps in data, significant amounts of groundwork are warranted for a testing strategy to be established on a sound scientific basis.
Citation
Hougaard, K. S., Campagnolo, L., Chavatte-Palmer, P., Tarrade, A., Rousseau-Ralliard, D., Valentino, S., Park, M. V. D. Z., de Jong, W. H., Wolterink, G., Piersma, A. H., Ross, B. L., Hutchison, G. R., Hansen, J. S., Vogel, U., Jackson, P., Slama, R., Pietroiusti, A., & Cassee, F. R. (2015). A perspective on the developmental toxicity of inhaled nanoparticles. Reproductive Toxicology, 56, 118-140. https://doi.org/10.1016/j.reprotox.2015.05.015
Journal Article Type | Article |
---|---|
Publication Date | 2015-08 |
Deposit Date | Oct 29, 2015 |
Publicly Available Date | Nov 26, 2019 |
Print ISSN | 0890-6238 |
Electronic ISSN | 1873-1708 |
Publisher | Elsevier |
Peer Reviewed | Peer Reviewed |
Volume | 56 |
Pages | 118-140 |
DOI | https://doi.org/10.1016/j.reprotox.2015.05.015 |
Keywords | Nanoparticles; Nanomaterial; Ultrafine particles; Developmental toxicity; Reproductive toxicity; Inhalation; Instillation; Pregnancy; |
Public URL | http://researchrepository.napier.ac.uk/id/eprint/9244 |
Publisher URL | http://dx.doi.org/10.1016/j.reprotox.2015.05.015 |
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Copyright Statement
This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
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