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A perspective on the developmental toxicity of inhaled nanoparticles

Hougaard, Karin S�rig; Campagnolo, Luisa; Chavatte-Palmer, Pascale; Tarrade, Anne; Rousseau-Ralliard, Delphine; Valentino, Sarah; Park, Margriet V D Z; de Jong, Wim H; Wolterink, Gerrit; Piersma, Aldert H; Ross, Bryony L; Hutchison, Gary R; Hansen, Jitka Stilund; Vogel, Ulla; Jackson, Petra; Slama, R�my; Pietroiusti, Antonio; Cassee, Flemming R


Karin S�rig Hougaard

Luisa Campagnolo

Pascale Chavatte-Palmer

Anne Tarrade

Delphine Rousseau-Ralliard

Sarah Valentino

Margriet V D Z Park

Wim H de Jong

Gerrit Wolterink

Aldert H Piersma

Bryony L Ross

Jitka Stilund Hansen

Ulla Vogel

Petra Jackson

R�my Slama

Antonio Pietroiusti

Flemming R Cassee


This paper aimed to clarify whether maternal inhalation of engineered nanoparticles (NP) may constitute a hazard to pregnancy and fetal development, primarily based on experimental animal studies of NP and air pollution particles. Overall, it is plausible that NP may translocate from the respiratory tract to the placenta and fetus, but also that adverse effects may occur secondarily to maternal inflammatory responses. The limited database describes several organ systems in the offspring to be potentially sensitive to maternal inhalation of particles, but large uncertainties exist about the implications for embryo–fetal development and health later in life. Clearly, the potential for hazard remains to be characterized. Considering the increased production and application of nanomaterials and related consumer products a testing strategy for NP should be established. Due to large gaps in data, significant amounts of groundwork are warranted for a testing strategy to be established on a sound scientific basis.

Journal Article Type Article
Publication Date 2015-08
Deposit Date Oct 29, 2015
Publicly Available Date Nov 26, 2019
Print ISSN 0890-6238
Electronic ISSN 1873-1708
Publisher Elsevier
Peer Reviewed Peer Reviewed
Volume 56
Pages 118-140
Keywords Nanoparticles; Nanomaterial; Ultrafine particles; Developmental toxicity; Reproductive toxicity; Inhalation;
Instillation; Pregnancy;
Public URL
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