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Health-Related Quality of Life for individuals with hepatitis C: A narrative review

Whiteley, David; Elliott, Lawrie; Cunningham-Burley, Sarah; Whittaker, Anne


David Whiteley

Lawrie Elliott

Sarah Cunningham-Burley

Anne Whittaker



The assessment of Health-Related Quality of Life (HRQoL) in hepatitis C (HCV) infected individuals continues to gain importance. However, rarely do reviews of this literature consider quantitative and qualitative accounts of HRQoL collectively, which only allows partial insight into the topic. This narrative review aims to address this gap in the literature.


Literature searches were conducted using seven databases with two separate search strategies, and results assessed for eligibility using specific inclusion/exclusion criteria; a data extraction sheet was used to identify the dominant themes for each research paradigm which were then distilled to key findings to construct the narrative.


Quantitative investigation reveals a low HRQoL in individuals with HCV due to a complex multifactorial cause. During treatment for HCV, a further transient reduction is observed, followed by improvement if a sustained virological response is achieved. Qualitative data provide a recognisable voice to the everyday challenges experienced by individuals with HCV including insights into diagnosis and stigmatisation, contextualising how a reduced HRQoL is experienced day-to-day. Methodological limitations of these findings are then discussed. Much of the quantitative data has little relevance to current substance users as they are excluded from most trials, and appraisal of the qualitative literature reveals a marked difference in the lived experience of HCV infected current substance users and that of other HCV groups.


Concurrent analysis of quantitative and qualitative paradigms provides a deeper understanding of the true burden of HCV illness on HRQoL. Greater utilisation of qualitative research within international clinical guidelines is likely to be of benefit in identifying relevant HRQoL outcomes for substance users.

Journal Article Type Article
Acceptance Date Apr 24, 2015
Online Publication Date May 7, 2015
Publication Date 2015-10
Deposit Date Oct 23, 2015
Publicly Available Date May 8, 2016
Journal International Journal of Drug Policy
Print ISSN 0955-3959
Publisher Elsevier
Peer Reviewed Peer Reviewed
Volume 26
Issue 10
Pages 936-949
Keywords Health-Related Quality of Life; Hepatitis C; Injecting drug users; Lived experience
Public URL
Publisher URL 10.1016/j.drugpo.2015.04.019
Contract Date Oct 23, 2015


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