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How to halve ploidy during meiosis – Lessons from budding yeast

Kerr, Gary; Sarkar, Sourav; Arumugam, Prakash

Authors

Sourav Sarkar

Prakash Arumugam



Abstract

Maintenance of ploidy in sexually reproducing organisms requires a specialized form of cell division called meiosis that generates genetically diverse haploid gametes from diploid germ cells. Meiotic cells halve their ploidy by undergoing two rounds of nuclear division (meiosis I and II) after a single round of DNA replication. Research in Saccharomyces cerevisiae (budding yeast) has shown that four major deviations from the mitotic cell cycle during meiosis are essential for halving ploidy. The deviations are (1) formation of a link between homologous chromosomes by crossover, (2) monopolar attachment of sister kinetochores during meiosis I, (3) protection of centromeric cohesion during meiosis I, and (4) suppression of DNA replication following exit from meiosis I. In this review we present the current understanding of the above four processes in budding yeast and examine the possible conservation of molecular mechanisms from yeast to humans.

Journal Article Type Review
Acceptance Date Mar 13, 2012
Online Publication Date Apr 6, 2012
Publication Date 2012-09
Deposit Date Feb 19, 2019
Journal Cellular and Molecular Life Sciences
Print ISSN 1420-682X
Publisher BMC
Peer Reviewed Peer Reviewed
Volume 69
Issue 18
Pages 3037-3051
DOI https://doi.org/10.1007/s00018-012-0974-9
Keywords Meiosis, Gametogenesis, Ploidy, Cell cycle, Shugoshin, Monopolin, FEAR,
Public URL http://researchrepository.napier.ac.uk/Output/1596271
Publisher URL https://link.springer.com/article/10.1007%2Fs00018-012-0974-9