All Outputs (4)

Life course longitudinal growth and risk of knee osteoarthritis at age 53 years: evidence from the 1946 British birth cohort study (2020)
Journal Article
Staines, K. A., Hardy, R., Samvelyan, H. J., Ward, K. A., & Cooper, R. (2021). Life course longitudinal growth and risk of knee osteoarthritis at age 53 years: evidence from the 1946 British birth cohort study. Osteoarthritis and Cartilage, 29(3), 335-340. https://doi.org/10.1016/j.joca.2020.12.012

Objective To examine the relationship between height gain across childhood and adolescence with knee osteoarthritis in the MRC National Survey of Health and Development (NSHD). Materials and methods Data are from 3035 male and female participant... Read More about Life course longitudinal growth and risk of knee osteoarthritis at age 53 years: evidence from the 1946 British birth cohort study.

Zinc ameliorates human aortic valve calcification through GPR39 mediated ERK1/2 signalling pathway (2020)
Journal Article
Chen, Z., Gordillo-Martinez, F., Jiang, L., He, P., Hong, W., Wei, X., …Zhu, D. (2021). Zinc ameliorates human aortic valve calcification through GPR39 mediated ERK1/2 signalling pathway. Cardiovascular Research, 117(3), 820-835. https://doi.org/10.1093/cvr/cvaa090

Aims Calcific aortic valve disease (CAVD) is the most common heart valve disease in the Western world. It has been reported that zinc is accumulated in calcified human aortic valves. However, whether zinc directly regulates CAVD is yet to be elucida... Read More about Zinc ameliorates human aortic valve calcification through GPR39 mediated ERK1/2 signalling pathway.

Models of osteoarthritis: relevance and new insights (2020)
Journal Article
Samvelyan, H., Hughes, D., Stevens, C., & Staines, K. A. (2021). Models of osteoarthritis: relevance and new insights. Calcified Tissue International, 109(3), 243-256. https://doi.org/10.1007/s00223-020-00670-x

Osteoarthritis (OA) is a progressive and disabling musculoskeletal disease affecting millions of people and resulting in major healthcare costs worldwide. It is the most common form of arthritis, characterised by degradation of the articular cartilag... Read More about Models of osteoarthritis: relevance and new insights.

Conditional deletion of E11/Podoplanin in bone protects against ovariectomy-induced increases in osteoclast formation and activity (2020)
Journal Article
Staines, K., Hopkinson, M., Dillon, S., Stephen, L., Fleming, R., Sophocleous, A., …Farquharson, C. (2020). Conditional deletion of E11/Podoplanin in bone protects against ovariectomy-induced increases in osteoclast formation and activity. Bioscience Reports, 40(1), https://doi.org/10.1042/BSR20190329

E11/Podoplanin (Pdpn) is implicated in early osteocytogenesis and the formation of osteocyte dendrites. This dendritic network is critical for bone modeling/remodeling, through the production of the receptor for receptor activator of nuclear factor κ... Read More about Conditional deletion of E11/Podoplanin in bone protects against ovariectomy-induced increases in osteoclast formation and activity.