A complete shikimate pathway in Toxoplasma gondii: an ancient eukaryotic innovation

Campbell, S.A.; Campbell, Samantha A; Richards, T.A.; Mui, E.J.; Samuel, B.U.; Coggins, J.R.; McLeod, R.; Roberts, C.W.

doi:10.1016/j.ijpara.2003.10.006

All Outputs (2)

The Structure of Escherichia coli ATP-phosphoribosyltransferase: Identification of Substrate Binding Sites and Mode of AMP Inhibition (2003)
Journal Article
Lohkamp, B., McDermott, G., Campbell, S. A., Coggins, J. R., & Lapthorn, A. J. (2004). The Structure of Escherichia coli ATP-phosphoribosyltransferase: Identification of Substrate Binding Sites and Mode of AMP Inhibition. Journal of Molecular Biology, 336(1), 131-144. https://doi.org/10.1016/j.jmb.2003.12.020

ATP-phosphoribosyltransferase (ATP-PRT), the first enzyme of the histidine pathway, is a complex allosterically regulated enzyme, which controls the flow of intermediates through this biosynthetic pathway. The crystal structures of Escherichia coli A... Read More about The Structure of Escherichia coli ATP-phosphoribosyltransferase: Identification of Substrate Binding Sites and Mode of AMP Inhibition.

A complete shikimate pathway in Toxoplasma gondii: an ancient eukaryotic innovation (2003)
Journal Article
Campbell, S., Campbell, S. A., Richards, T., Mui, E., Samuel, B., Coggins, J., …Roberts, C. (2004). A complete shikimate pathway in Toxoplasma gondii: an ancient eukaryotic innovation. International Journal for Parasitology, 34(1), 5-13. https://doi.org/10.1016/j.ijpara.2003.10.006

The shikimate pathway is essential for survival of the apicomplexan parasites Plasmodium falciparum, Toxoplasma gondii and Cryptosporidium parvum. As it is absent in mammals it is a promising therapeutic target. Herein, we describe the genes encoding... Read More about A complete shikimate pathway in Toxoplasma gondii: an ancient eukaryotic innovation.