All Outputs (3)

Genome-wide association scan identifies a colorectal cancer susceptibility locus on 11q23 and replicates risk loci at 8q24 and 18q21 (2008)
Journal Article
Tenesa, A., Farrington, S. M., Prendergast, J. G. D., Porteous, M. E., Walker, M., Haq, N., …Dunlop, M. G. (2008). Genome-wide association scan identifies a colorectal cancer susceptibility locus on 11q23 and replicates risk loci at 8q24 and 18q21. Nature Genetics, 40, 631-637. https://doi.org/10.1038/ng.133

In a genome-wide association study to identify loci associated with colorectal cancer (CRC) risk, we genotyped 555,510 SNPs in 1,012 early-onset Scottish CRC cases and 1,012 controls (phase 1). In phase 2, we genotyped the 15,008 highest-ranked SNPs... Read More about Genome-wide association scan identifies a colorectal cancer susceptibility locus on 11q23 and replicates risk loci at 8q24 and 18q21.

Modification of the associations between lifestyle, dietary factors and colorectal cancer risk by APC variants (2008)
Journal Article
Theodoratou, E., Campbell, H., Tenesa, A., McNeill, G., Cetnarskyj, R., Barnetson, R. A., …Farrington, S. M. (2008). Modification of the associations between lifestyle, dietary factors and colorectal cancer risk by APC variants. Carcinogenesis, 29, 1774-1780. https://doi.org/10.1093/carcin/bgn082

In a large Scottish case–control study, we investigated the effects of adenomatous polyposis coli (APC) Asp1822Val (rs459552) and APC Glu1317Gln substitutions on colorectal cancer (CRC) risk and whether these associations were influenced by lifestyle... Read More about Modification of the associations between lifestyle, dietary factors and colorectal cancer risk by APC variants.

Modification of the inverse association between dietary vitamin D intake and colorectal cancer risk by aFokI variant supports a chemoprotective action of Vitamin D intake mediated through VDR binding (2008)
Journal Article
Theodoratou, E., Farrington, S. M., Tenesa, A., McNeill, G., Cetnarskyj, R., Barnetson, R. A., …Campbell, H. (2008). Modification of the inverse association between dietary vitamin D intake and colorectal cancer risk by aFokI variant supports a chemoprotective action of Vitamin D intake mediated through VDR binding. International Journal of Cancer, 123, 2170-2179. https://doi.org/10.1002/ijc.23769

Vitamin D has anticarcinogenic properties and might influence colorectal cancer (CRC) risk, but the epidemiological evidence is inconsistent. Many mechanisms of action for vitamin D have been proposed, with some of them initiating via its binding to... Read More about Modification of the inverse association between dietary vitamin D intake and colorectal cancer risk by aFokI variant supports a chemoprotective action of Vitamin D intake mediated through VDR binding.