Design, synthesis, and cytotoxicity of bifunctional anticancer agents targeted to mitochondria
(2023)
Thesis
Kamel, M. A. Design, synthesis, and cytotoxicity of bifunctional anticancer agents targeted to mitochondria. (Thesis). Edinburgh Napier University
One of the major challenges of cancer chemotherapy is multidrug resistance (MDR) leading to failure and drug withdrawal. A major factor in drug resistance is the overexpression of transmembrane P-gp protein efflux pumps in cancer cell membranes that... Read More about Design, synthesis, and cytotoxicity of bifunctional anticancer agents targeted to mitochondria.