All Outputs (2)

P088 Involvement of NMDAR in chondrocyte cell death and matrix degeneration (2009)
Presentation / Conference
Ramage, L., Hardingham, G., & Salter, D. (2009, June). P088 Involvement of NMDAR in chondrocyte cell death and matrix degeneration. Paper presented at 2nd Joint meeting of the Bone Research Society and the British Society for Matrix Biology

NMDA receptors (NMDAR) are expressed by chondrocytes in articular cartilage although their function is yet to be fully understood. NMDAR are ionotropic glutamate receptors which when excessively stimulated in neurones induce cell death and neuron... Read More about P088 Involvement of NMDAR in chondrocyte cell death and matrix degeneration.

Signalling cascades in mechanotransduction: cell-matrix interactions and mechanical loading (2009)
Journal Article
Ramage, L., Nuki, G., & Salter, D. M. (2009). Signalling cascades in mechanotransduction: cell-matrix interactions and mechanical loading. Scandinavian Journal of Medicine and Science in Sports, 19(4), 457-469. https://doi.org/10.1111/j.1600-0838.2009.00912.x

Mechanical loading of articular cartilage stimulates the metabolism of resident chondrocytes and induces the synthesis of molecules to maintain the integrity of the cartilage. Mechanical signals modulate biochemical activity and changes in cell behav... Read More about Signalling cascades in mechanotransduction: cell-matrix interactions and mechanical loading.