Metformin selectively targets redox control of complex I energy transduction
(2017)
Journal Article
Cameron, A. R., Logie, L., Patel, K., Erhardt, S., Bacon, S., Middleton, P., …Rena, G. (2018). Metformin selectively targets redox control of complex I energy transduction. Redox Biology, 14, 187-197. https://doi.org/10.1016/j.redox.2017.08.018
Many guanide-containing drugs are antihyperglycaemic but most exhibit toxicity, to the extent that only the biguanide metformin has enjoyed sustained clinical use. Here, we have isolated unique mitochondrial redox control properties of metformin that... Read More about Metformin selectively targets redox control of complex I energy transduction.