Outputs (13)

Making Sense of Surgical Flaps (1992)
Journal Article
Coull, A. F. (1992). Making Sense of Surgical Flaps. Nursing Times, 88(1),

No abstract available.

Making Sense of Pulse Oximetry (1992)
Journal Article
Coull, A. F. (1992). Making Sense of Pulse Oximetry. Nursing Times, 88(32),

No abstract available.

The Isolation of Genomic DNA from Invertebrates (1992)
Book Chapter
Vreugdenhil, E., & Darlison, M. G. (1992). The Isolation of Genomic DNA from Invertebrates. In A. Longstaff, & P. Revest (Eds.), Protocols in Molecular Neurobiology (15-24). Springer. https://doi.org/10.1385/0-89603-199-3%3A15

Generally, genomic DNA is used either for the construction of genomic libraries or for Southern blot analysis. For several reasons, it is frequently preferable in the field of invertebrate neurobiology to screen, at least initially, genomic rather th... Read More about The Isolation of Genomic DNA from Invertebrates.

Invertebrate GABA and glutamate receptors: molecular biology reveals predictable structures but some unusual pharmacologies (1992)
Journal Article
Darlison, M. G. (1992). Invertebrate GABA and glutamate receptors: molecular biology reveals predictable structures but some unusual pharmacologies. Trends in Neurosciences, 15(12), 469-474. https://doi.org/10.1016/0166-2236%2892%2990091-l

Determination of the sequences of invertebrate γ-aminobutyric acid (GABA)-gated and glutamate-gated receptor/ion channels, through the application of recombinant {DNA} methods, is not just an academic exercise to effect evolutionary comparisons with... Read More about Invertebrate GABA and glutamate receptors: molecular biology reveals predictable structures but some unusual pharmacologies.

GABAA receptor subunit genes as candidate genes for bipolar affective disorder—an association analysis (1992)
Journal Article
Walsh, C., Hicks, A. A., Sham, P., Castle, D., Hunt, N., Clements, A., Sander, T., Murray, R., Darlison, M. G., & Gill, M. (1992). GABAA receptor subunit genes as candidate genes for bipolar affective disorder—an association analysis. Psychiatric Genetics, 2(4), 239-248. https://doi.org/10.1097/00041444-199210000-00002

Polymorphic DNA segments can be used as genetic markers to test for allelic association between a disease and a candidate gene locus. Here we report the results of a study of 60 unrelated bipolar patients in which we sought for evidence of associatio... Read More about GABAA receptor subunit genes as candidate genes for bipolar affective disorder—an association analysis.

Physiotherapy Management of Chronic Low Back Pain (1992)
Journal Article
Frost, H., & Moffett, J. K. (1992). Physiotherapy Management of Chronic Low Back Pain. Physiotherapy, 78(10), 751-754. https://doi.org/10.1016/s0031-9406%2810%2961638-0

Disability reported as a result of low back pain (LBP) has increased dramatically over the last 20 years. This paper reviews some of the scientific evidence currently available for the treatment of patients with LBP. The advantages of a more active a... Read More about Physiotherapy Management of Chronic Low Back Pain.

QALYs in mental health: a case study (1992)
Journal Article
Wilkinson, G., Williams, B., Krekorian, H., McLees, S., & Falloon, I. (1992). QALYs in mental health: a case study. Psychological Medicine, 22(3), 725. https://doi.org/10.1017/S0033291700038162

The applicability of the Charing Cross health indicator (CH-X) to the field of mental health was investigated in a community setting using descriptive statistics and principal components analysis. The CH-X is based on assessments of (i) distress and... Read More about QALYs in mental health: a case study.

Unusual effects of benzodiazepines and cyclodiene insecticides on an expressed invertebrate GABAAreceptor (1992)
Journal Article
Zaman, S. H., Harvey, R. J., Barnard, E. A., & Darlison, M. G. (1992). Unusual effects of benzodiazepines and cyclodiene insecticides on an expressed invertebrate GABAAreceptor. FEBS Letters, 307(3), 351-354. https://doi.org/10.1016/0014-5793%2892%2980711-o

We have previously reported [(1991) EMBO J. 10, 3239–3245] the sequence of an invertebrate γ‐aminobutyric acid (GABA) type A (GABAA) receptor polypeptide which forms homo‐oligomeric GABA‐gated, bicuculline‐sensitive, chloride‐ion channels upon hetero... Read More about Unusual effects of benzodiazepines and cyclodiene insecticides on an expressed invertebrate GABAAreceptor.

Assembly of functional GABAA receptors in insect cells using baculovirus expression vectors (1992)
Journal Article
Atkinson, A. E., Bermudez, I., Darlison, M. G., Barnard, E. A., Earley, F. G. P., Possee, R. D., Beadle, D. J., & King, L. A. (1992). Assembly of functional GABAA receptors in insect cells using baculovirus expression vectors. NeuroReport, 3(7), 597-600. https://doi.org/10.1097/00001756-199207000-00013

We have constructed recombinant baculoviruses containing cDNAs encoding either the [alpha]1- or the [beta]1-subunit of the bovine GABAA receptor. In Spodoptera frugiperda (IPLB-Sf-21) cells infected with recombinant virus expressing either the [alpha... Read More about Assembly of functional GABAA receptors in insect cells using baculovirus expression vectors.

Fine mapping of the human biglycan (BGN) gene within the Xq28 region employing a hybrid cell panel (1992)
Journal Article
Traupe, H., Ouweland, A. M. V. D., Oost, B. A. V., Vogel, W., Vetter, U., Warren, S. T., Rocchi, M., Darlison, M. G., & Ropers, H.-H. (1992). Fine mapping of the human biglycan (BGN) gene within the Xq28 region employing a hybrid cell panel. Genomics, 13(2), 481-483. https://doi.org/10.1016/0888-7543%2892%2990279-2

Human biglycan is a small proteoglycan that is expressed at high levels in the growing skeleton and in human skin at the cell surface of differentiating keratinocytes. The human gene for biglycan (BGN) has previously been mapped by in situ hybridizat... Read More about Fine mapping of the human biglycan (BGN) gene within the Xq28 region employing a hybrid cell panel.

Effects of subunit types of the recombinant GABAA receptor on the response to a neurosteroid (1992)
Journal Article
Zaman, S. H., Shingai, R., Harvey, R. J., Darlison, M. G., & Barnard, E. A. (1992). Effects of subunit types of the recombinant GABAA receptor on the response to a neurosteroid. European journal of pharmacology. Molecular pharmacology section, 225(4), 321-330. https://doi.org/10.1016/0922-4106%2892%2990106-6

When vertebrate brain poly(A)+ RNA is expressed in Xenopus oocytes the response of the GABA receptors formed is found to be inhibited allosterically by a neurosteroid, pregnenolone sulphate (PS). This negative modulation was reproduced after expressi... Read More about Effects of subunit types of the recombinant GABAA receptor on the response to a neurosteroid.

Differential Localization of Two Alternatively Spliced GABAAReceptor γ2-Subunit mRNAs in the Chick Brain (1992)
Journal Article
Glencorse, T. A., Bateson, A. N., & Darlison, M. G. (1992). Differential Localization of Two Alternatively Spliced GABAAReceptor γ2-Subunit mRNAs in the Chick Brain. European Journal of Neuroscience, 4(3), 271-277. https://doi.org/10.1111/j.1460-9568.1992.tb00874.x

Two variants of the GABAA receptor γ2 subunit are known to exist, which differ by the presence (γ2L) or absence (γ2S) of eight amino acids in the presumed intracellular loop between the third and fourth membrane-spanning domains. These variants have... Read More about Differential Localization of Two Alternatively Spliced GABAAReceptor γ2-Subunit mRNAs in the Chick Brain.

Publicity problems. (1992)
Journal Article
Frost, H., & Sylvester, K. (1992). Publicity problems. Physiotherapy, 78(2), 123

No abstract available.