Outputs (8)

The type III intermediate filament vimentin regulates organelle distribution and modulates autophagy (2019)
Journal Article
Biskou, O., Casanova, V., Hooper, K., Kemp, S., Wright, G. P., Satsangi, J., Barlow, P., & Stevens, C. (2019). The type III intermediate filament vimentin regulates organelle distribution and modulates autophagy. PLOS ONE, 14(1), Article e0209665. https://doi.org/10.1371/journal.pone.0209665

The cytoskeletal protein vimentin plays a key role in positioning of organelles within the cytosol and has been linked to the regulation of numerous cellular processes including autophagy, however, how vimentin regulates autophagy remains relatively... Read More about The type III intermediate filament vimentin regulates organelle distribution and modulates autophagy.

Belonging to a learning community: staff perspectives. (2018)
Presentation / Conference Contribution
Ennis, L., Tierney, A., Lucas, L., Logan, P., & Wright, G. (2018, October). Belonging to a learning community: staff perspectives. Presented at Evidence for Enhancement: The Challenge of Community and Belonging, Edinburgh, Scotland

The Faculty Learning Community (FLC) at Edinburgh Napier University is based on the Miami model developed by Milton D. Cox and seeks to explore the ways in which staff support each other throughout the institution. This formal, time-bound and selecti... Read More about Belonging to a learning community: staff perspectives..

Lower Resting and Exercise-Induced Circulating Angiogenic Progenitors and Angiogenic T-Cells in Older Men (2017)
Journal Article
Ross, M. D., Malone, E. M., Simpson, R., Cranston, I., Ingram, L., Wright, G. P., Chambers, G., & Florida-James, G. D. (2018). Lower Resting and Exercise-Induced Circulating Angiogenic Progenitors and Angiogenic T-Cells in Older Men. American journal of physiology. Heart and circulatory physiology, 314(3), 392-402. https://doi.org/10.1152/ajpheart.00592.2017

Ageing is associated with a dysfunctional endothelial phenotype, as well as reduced angiogenic capabilities. Exercise exerts beneficial effects on the cardiovascular system, possibly by increasing/maintaining the number and/or function of circulating... Read More about Lower Resting and Exercise-Induced Circulating Angiogenic Progenitors and Angiogenic T-Cells in Older Men.

Remote ischaemic preconditioning in orthotopic liver transplantation (RIPCOLT trial): a pilot randomized controlled feasibility study (2017)
Journal Article
Robertson, F. P., Goswami, R., Wright, G. P., Imber, C., Sharma, D., Malago, M., Fuller, B. J., & Davidson, B. R. (2017). Remote ischaemic preconditioning in orthotopic liver transplantation (RIPCOLT trial): a pilot randomized controlled feasibility study. HPB, 19(9), 757-767. https://doi.org/10.1016/j.hpb.2017.05.005

Background
Ischaemia Reperfusion (IR) injury is a major cause of morbidity, mortality and graft loss following Orthotopic Liver Transplantation (OLT). Utilising marginal grafts, which are more susceptible to IR injury, makes this a key research goal... Read More about Remote ischaemic preconditioning in orthotopic liver transplantation (RIPCOLT trial): a pilot randomized controlled feasibility study.

CD3 limits the efficacy of TCR gene therapy in vivo (2011)
Journal Article
Ahmadi, M., King, J. W., Xue, S. A., Voisine, C., Holler, A., Wright, G. P., Waxman, J., Morris, E., & Stauss, H. J. (2011). CD3 limits the efficacy of TCR gene therapy in vivo. Blood, 118(13), 3528-3537. https://doi.org/10.1182/blood-2011-04-346338

The function of T-cell receptor (TCR) gene modified T cells is dependent on efficient surface expression of the introduced TCR
/ heterodimer. We tested whether endogenous CD3 chains are rate-limiting for TCR expression and antigen-specific T-cell fu... Read More about CD3 limits the efficacy of TCR gene therapy in vivo.

Therapeutic potential of Tregs to treat rheumatoid arthritis (2011)
Journal Article
Wright, G. P., Stauss, H. J., & Ehrenstein, M. R. (2011). Therapeutic potential of Tregs to treat rheumatoid arthritis. Seminars in Immunology, 23(3), 195-201. https://doi.org/10.1016/j.smim.2011.07.004

There is accumulating evidence for regulatory T cell defects in rheumatoid arthritis and that some biologic interventions, in particular anti-TNF, can target this population. Despite the challenges in defining regulatory T cells in patients, there ar... Read More about Therapeutic potential of Tregs to treat rheumatoid arthritis.

Natural IgM Is Required for Suppression of Inflammatory Arthritis by Apoptotic Cells (2011)
Journal Article
Notley, C. A., Brown, M. A., Wright, G. P., & Ehrenstein, M. R. (2011). Natural IgM Is Required for Suppression of Inflammatory Arthritis by Apoptotic Cells. The journal of immunology : official journal of the American Association of Immunologists, 186(8), 4967-4972. https://doi.org/10.4049/jimmunol.1003021

The clearance of dying cells is vital for re-establishing tolerance during inflammation and has potent immunoregulatory consequences. Because natural IgM plays a key role in the removal of apoptotic cells, we investigated whether the immune modulator... Read More about Natural IgM Is Required for Suppression of Inflammatory Arthritis by Apoptotic Cells.

Adoptive therapy with redirected primary regulatory T cells results in antigen-specific suppression of arthritis (2009)
Journal Article
Wright, G. P., Notley, C. A., Xue, S. A., Bendle, G. M., Holler, A., Schumacher, T. N., Ehrenstein, M. R., & Stauss, H. J. (2009). Adoptive therapy with redirected primary regulatory T cells results in antigen-specific suppression of arthritis. Proceedings of the National Academy of Sciences, 106(45), 19078-19083. https://doi.org/10.1073/pnas.0907396106

Regulatory T cells (Tregs) can suppress a wide range of immune cells, making them an ideal candidate for the treatment of autoimmunity. The potential clinical translation of targeted therapy with antigen-specific Tregs is hampered by the difficulties... Read More about Adoptive therapy with redirected primary regulatory T cells results in antigen-specific suppression of arthritis.