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Outputs (6)

Identification of the mechanisms that drive the toxicity of TiO2 particulates: the contribution of physicochemical characteristics (2009)
Journal Article
Johnston, H. J., Hutchison, G. R., Christensen, F. M., Peters, S., Hankin, S., & Stone, V. (2009). Identification of the mechanisms that drive the toxicity of TiO2 particulates: the contribution of physicochemical characteristics. Particle and fibre toxicology, 6(1), 33. https://doi.org/10.1186/1743-8977-6-33

This review focuses on outlining the toxicity of titanium dioxide (TiO₂) particulates in vitro and in vivo, in order to understand their ability to detrimentally impact on human health. Evaluating the hazards associated with TiO₂ particles is vital a... Read More about Identification of the mechanisms that drive the toxicity of TiO2 particulates: the contribution of physicochemical characteristics.

Glucocorticoids Amplify Dibutyl Phthalate-Induced Disruption of Testosterone Production and Male Reproductive Development (2009)
Journal Article
Drake, A. J., van den Driesche, S., Scott, H. M., Hutchison, G. R., Seckl, J. R., & Sharpe, R. M. (2009). Glucocorticoids Amplify Dibutyl Phthalate-Induced Disruption of Testosterone Production and Male Reproductive Development. Endocrinology, 150(11), 5055-5064. https://doi.org/10.1210/en.2009-0700

Common male reproductive abnormalities including cryptorchidism, hypospadias, and low sperm counts may comprise a testicular dysgenesis syndrome (TDS), resulting from fetal testis dysfunction during a critical developmental period involving reduced a... Read More about Glucocorticoids Amplify Dibutyl Phthalate-Induced Disruption of Testosterone Production and Male Reproductive Development.

The Biological Mechanisms and Physicochemical Characteristics Responsible for Driving Fullerene Toxicity (2009)
Journal Article
Johnston, H. J., Hutchison, G. R., Christensen, F. M., Aschberger, K., & Stone, V. (2010). The Biological Mechanisms and Physicochemical Characteristics Responsible for Driving Fullerene Toxicity. Toxicological Sciences, 114(2), 162-182. https://doi.org/10.1093/toxsci/kfp265

This review provides a comprehensive critical review of the available literature purporting to assess the toxicity of carbon fullerenes. This is required as prior to the widespread utilization and production of fullerenes, it is necessary to consider... Read More about The Biological Mechanisms and Physicochemical Characteristics Responsible for Driving Fullerene Toxicity.

Death-associated protein kinase (DAPK) and signal transduction: additional roles beyond cell death: DAPK and signal transduction (2009)
Journal Article
Lin, Y., Hupp, T. R., & Stevens, C. (2010). Death-associated protein kinase (DAPK) and signal transduction: additional roles beyond cell death: DAPK and signal transduction. FEBS Journal, 277(1), 48-57. https://doi.org/10.1111/j.1742-4658.2009.07411.x

Death-associated protein kinase (DAPK) is a stress-regulated protein
kinase that mediates a range of processes, including signal-induced cell death and autophagy. Although the kinase domain of DAPK has a range of substrates that mediate its signalli... Read More about Death-associated protein kinase (DAPK) and signal transduction: additional roles beyond cell death: DAPK and signal transduction.

Secondary necrosis of apoptotic neutrophils induced by the human cathelicidin LL-37 is not proinflammatory to phagocytosing macrophages (2009)
Journal Article
Li, H., Barlow, P. G., Bylund, J., Mackellar, A., Björstad, Å., Conlon, J., Hiemstra, P. S., Haslett, C., Gray, M., Simpson, A. J., Rossi, A. G., & Davidson, D. J. (2009). Secondary necrosis of apoptotic neutrophils induced by the human cathelicidin LL-37 is not proinflammatory to phagocytosing macrophages. Journal of Leukocyte Biology, 86(4), 891-902. https://doi.org/10.1189/jlb.0209050

Cathelicidins are CHDP with essential roles in innate host defense but also more recently associated with the pathogenesis of certain chronic diseases. These peptides have microbicidal potential and the capacity to modulate innate immunity and inflam... Read More about Secondary necrosis of apoptotic neutrophils induced by the human cathelicidin LL-37 is not proinflammatory to phagocytosing macrophages.