Skip to main content

Research Repository

Advanced Search

Preferential activation of HIF-2 adaptive mechanisms in neuronal-like cells in response to hypoxia (2017)
Presentation / Conference
Fraser, J., Baudel, M., Rae, M., Darlison, M., & Poole, A. (2017, April). Preferential activation of HIF-2 adaptive mechanisms in neuronal-like cells in response to hypoxia. Poster presented at British Neuroscience Association - festival of neuroscience 2017

Stroke is a leading cause of death and disability worldwide. Blockage, or occlusion, of cerebral arteries causes irreversible neuronal damage as disrupted blood flow starves neurones of oxygen and glucose. The hypoxia inducible factors (HIFs) are mas... Read More about Preferential activation of HIF-2 adaptive mechanisms in neuronal-like cells in response to hypoxia.

New developments in osteoarthritis and cartilage biology (2016)
Journal Article
Poulet, B., & Staines, K. A. (2016). New developments in osteoarthritis and cartilage biology. Current Opinion in Pharmacology, 28, 8-13. https://doi.org/10.1016/j.coph.2016.02.009

Osteoarthritis (OA) is a degenerative joint disease and the most common form of arthritis. Characterised by articular cartilage loss, subchondral bone thickening and osteophyte formation, the OA joint afflicts much pain and disability. Whilst OA has... Read More about New developments in osteoarthritis and cartilage biology.

A perspective on the developmental toxicity of inhaled nanoparticles (2015)
Journal Article
Hougaard, K. S., Campagnolo, L., Chavatte-Palmer, P., Tarrade, A., Rousseau-Ralliard, D., Valentino, S., …Cassee, F. R. (2015). A perspective on the developmental toxicity of inhaled nanoparticles. Reproductive Toxicology, 56, 118-140. https://doi.org/10.1016/j.reprotox.2015.05.015

This paper aimed to clarify whether maternal inhalation of engineered nanoparticles (NP) may constitute a hazard to pregnancy and fetal development, primarily based on experimental animal studies of NP and air pollution particles. Overall, it is plau... Read More about A perspective on the developmental toxicity of inhaled nanoparticles.

Multi-walled carbon nanotube induced frustrated phagocytosis, cytotoxicity and pro-inflammatory conditions in macrophages are length dependent and greater than that of asbestos (2015)
Journal Article
Boyles, M. S., Young, L., Brown, D. M., MacCalman, L., Cowie, H., Moisala, A., …Stone, V. (2015). Multi-walled carbon nanotube induced frustrated phagocytosis, cytotoxicity and pro-inflammatory conditions in macrophages are length dependent and greater than that of asbestos. Toxicology in Vitro, 29(7), 1513-1528. https://doi.org/10.1016/j.tiv.2015.06.012

The potential toxicity of carbon nanotubes (CNTs) has been compared to pathogenic fibres such as asbestos. It is important to test this hypothesis to ascertain safe methods for CNT production, handling and disposal. In this study aspects reported to... Read More about Multi-walled carbon nanotube induced frustrated phagocytosis, cytotoxicity and pro-inflammatory conditions in macrophages are length dependent and greater than that of asbestos.

Invadolysin acts genetically via the SAGA complex to modulate chromosome structure (2015)
Journal Article
Janiszewski, M. M., Heck, M. M., Rao, S. G., Janiszewski, M. M., Duca, E., Nelson, B., …Heck, M. M. S. (2015). Invadolysin acts genetically via the SAGA complex to modulate chromosome structure. Nucleic Acids Research, 43(7), 3546-3562. https://doi.org/10.1093/nar/gkv211

Identification of components essential to chromosome structure and behaviour remains a vibrant area of study. We have previously shown that invadolysin is essential in Drosophila, with roles in cell division and cell migration. Mitotic chromosomes ar... Read More about Invadolysin acts genetically via the SAGA complex to modulate chromosome structure.

The Glycosylation of AGP and Its Associations with the Binding to Methadone (2013)
Journal Article
Behan, J. L., Cruickshank, Y. E., Matthews-Smith, G., Bruce, M., & Smith, K. D. (2013). The Glycosylation of AGP and Its Associations with the Binding to Methadone. BioMed Research International, 2013, 1-7. https://doi.org/10.1155/2013/108902

Methadone remains the most common form of pharmacological therapy for opioid dependence; however, there is a lack of explanation for the reports of its relatively low success rate in achieving complete abstinence. One hypothesis is that in vivo bind... Read More about The Glycosylation of AGP and Its Associations with the Binding to Methadone.

The well-being outcomes of career guidance (2013)
Journal Article
Robertson, P. J. (2013). The well-being outcomes of career guidance. British Journal of Guidance and Counselling, 41(3), 254-266. https://doi.org/10.1080/03069885.2013.773959

The potential for career guidance to impact on well-being has received insufficient attention in the UK. There are both conceptual and empirical reasons to expect that the impacts may be positive, but a lack of evidence directly testing this proposit... Read More about The well-being outcomes of career guidance.

Zinc oxide nanoparticles and monocytes: Impact of size, charge and solubility on activation status (2012)
Journal Article
Prach, M., Stone, V., & Proudfoot, L. (2012). Zinc oxide nanoparticles and monocytes: Impact of size, charge and solubility on activation status. Toxicology and Applied Pharmacology, 266(1), 19-26. https://doi.org/10.1016/j.taap.2012.10.020

Zinc oxide (ZnO) particle induced cytotoxicity was dependent on size, charge and solubility, factors which at sublethal concentrations may influence the activation of the human monocytic cell line THP1. ZnO nanoparticles (NP; average diameter 70 nm)... Read More about Zinc oxide nanoparticles and monocytes: Impact of size, charge and solubility on activation status.

Cartilage development and degeneration: a Wnt Wnt situation - cartilage development and degeneration: a WNT WNT situation (2012)
Journal Article
Staines, K. A., MacRae, V. E., & Farquharson, C. (2012). Cartilage development and degeneration: a Wnt Wnt situation - cartilage development and degeneration: a WNT WNT situation. Cell Biochemistry and Function, 30(8), 633-642. https://doi.org/10.1002/cbf.2852

The Wnt signaling pathway plays a crucial role in the development and homeostasis of a variety of adult tissues and, as such, is emerging as an important therapeutic target for numerous diseases. Factors involved in the Wnt pathway are expressed thro... Read More about Cartilage development and degeneration: a Wnt Wnt situation - cartilage development and degeneration: a WNT WNT situation.

The importance of the SIBLING family of proteins on skeletal mineralisation and bone remodelling (2012)
Journal Article
Staines, K. A., MacRae, V. E., & Farquharson, C. (2012). The importance of the SIBLING family of proteins on skeletal mineralisation and bone remodelling. Journal of Endocrinology, 214(3), 241-255. https://doi.org/10.1530/joe-12-0143

The small integrin-binding ligand N-linked glycoprotein (SIBLING) family consists of osteopontin, bone sialoprotein, dentin matrix protein 1, dentin sialophosphoprotein and matrix extracellular phosphoglycoprotein. These proteins share many structura... Read More about The importance of the SIBLING family of proteins on skeletal mineralisation and bone remodelling.

Activation of metabotropic glutamate receptor 7 in spinal cord inhibits pain and hyperalgesia in a novel formalin model in sheep (2011)
Journal Article
Dolan, S., Gunn, M. D., Crossan, C., & Nolan, A. M. (2011). Activation of metabotropic glutamate receptor 7 in spinal cord inhibits pain and hyperalgesia in a novel formalin model in sheep. Behavioural Pharmacology, 22, 582-588. https://doi.org/10.1097/FBP.0b013e3283478802

This study set out to characterize the contribution of group III metabotropic glutamate receptor 7 activation to nociceptive behaviour and mechanical hypersensitivity in a novel formalin test in sheep. The mGlu receptor 7 allosteric agonist, N,N′-dib... Read More about Activation of metabotropic glutamate receptor 7 in spinal cord inhibits pain and hyperalgesia in a novel formalin model in sheep.

Depressive symptons in early pregnancy disrupt attentional processing of infant emotion (2010)
Journal Article
Pearson, R. M., Cooper, R. M., Penton-Voak, I. S., Lightman, S., & Evans, J. (2010). Depressive symptons in early pregnancy disrupt attentional processing of infant emotion. Psychological Medicine, 40, 621-631. https://doi.org/10.1017/S0033291709990961

BACKGROUND: Growing evidence suggests that perinatal depression is associated with disrupted mother-infant interactions and poor infant outcomes. Antenatal depression may play a key role in this cycle by disrupting the development of a maternal respo... Read More about Depressive symptons in early pregnancy disrupt attentional processing of infant emotion.

Therapeutic effects of magnetic and copper bracelets in osteoarthritis: a randomised placebo controlled crossover trial (2009)
Journal Article
Richmond, S. J., Brown, S., Campion, P. D., Porter, A. J. L., Klaber Moffett, J. A., Jackson, D. A., …Taylor, A. J. (2009). Therapeutic effects of magnetic and copper bracelets in osteoarthritis: a randomised placebo controlled crossover trial. Complementary Therapies in Medicine, 17, 249-256. https://doi.org/10.1016/j.ctim.2009.07.002

Objectives: to test the effectiveness of a typical magnetic wrist strap for reducing pain and stiffness, and for improving physical functioning amongst patients with osteoarthritis. Design: a randomised double-blind placebo-controlled crossover trial... Read More about Therapeutic effects of magnetic and copper bracelets in osteoarthritis: a randomised placebo controlled crossover trial.

Evaluating the uptake, intracellular fate and functional consequences of hepatocyte exposure to a range of nanoparticles, in vitro (2009)
Thesis
Johnston, H. Evaluating the uptake, intracellular fate and functional consequences of hepatocyte exposure to a range of nanoparticles, in vitro. (Thesis). Edinburgh Napier University. Retrieved from http://researchrepository.napier.ac.uk/id/eprint/2548

The liver is recognised as a potential target site for nanoparticle (NP) toxicity, as NPs have been observed to accumulate within this organ subsequent to exposure via injection, inhalation or instillation. The liver’s unique structure has to be take... Read More about Evaluating the uptake, intracellular fate and functional consequences of hepatocyte exposure to a range of nanoparticles, in vitro.

Bendigoles A~C, New Steroids from Gordonia australis Acta 2299 (2008)
Journal Article
Schneider, K., Graf, E., Irran, E., Nicholson, G., Stainsby, F. M., Goodfellow, M., …Fiedler, H. (2008). Bendigoles A~C, New Steroids from Gordonia australis Acta 2299. Journal of Antibiotics, 61(6), 356-364. https://doi.org/10.1038/ja.2008.50

Bendigoles A~C are the first secondary metabolites to be isolated from a member of the actinomycete genus Gordonia. They were detected in a culture filtrate extract of Gordonia australis Acta 2299 by HPLC-diode array analysis and characterized as new... Read More about Bendigoles A~C, New Steroids from Gordonia australis Acta 2299.

Nanoparticle interactions with zinc and iron: Implications for toxicology and inflammation (2007)
Journal Article
Wilson, M. R., Foucaud, L., Barlow, P. G., Hutchison, G. R., Sales, J., Simpson, R. J., & Stone, V. (2007). Nanoparticle interactions with zinc and iron: Implications for toxicology and inflammation. Toxicology and Applied Pharmacology, 225(1), 80-89. https://doi.org/10.1016/j.taap.2007.07.012

Particulate air pollution (PM10) consists of a mixture of components, including nanoparticles and metals. Studies from our laboratory have demonstrated that transition metals can potentiate the ability of nanoparticles to induce lung inflammation and... Read More about Nanoparticle interactions with zinc and iron: Implications for toxicology and inflammation.

Devising and evaluating a model for teaching therapeutic handling and moving skills to complementary therapists (2007)
Journal Article
Donnelly, C., & MacMillan, M. S. (2007). Devising and evaluating a model for teaching therapeutic handling and moving skills to complementary therapists. Complementary Therapies in Clinical Practice, 13(3), 201-209. https://doi.org/10.1016/j.ctcp.2006.12.002

This two phase, mixed methods study, developed and evaluated the effectiveness of a model for teaching the neuromuscular approach (NMA) to human movement. From an original volunteer sample of 74 students, 33 completed the 15-week (Phase 1) moving and... Read More about Devising and evaluating a model for teaching therapeutic handling and moving skills to complementary therapists.

Hippocalcin functions as a calcium sensor in hippocampal LTD. (2005)
Journal Article
Palmer, C., Lim, W., Hastie, P. G. R., Toward, M., Korolchuk, V. I., Burbidge, S. A., …Henley, J. M. (2005). Hippocalcin functions as a calcium sensor in hippocampal LTD. Neuron, 47, 487-494. https://doi.org/10.1016/j.neuron.2005.06.014

It is not fully understood how NMDAR-dependent LTD causes Ca2+-dependent endocytosis of AMPARs. Here we show that the neuronal Ca2+ sensor hippocalcin binds the ?2-adaptin subunit of the AP2 adaptor complex and that along with GluR2 these coimmunopre... Read More about Hippocalcin functions as a calcium sensor in hippocampal LTD..

Targeting an MMP-9-activated prodrug to multiple myeloma diseased bone marrow: a proof of principle in the 5T33MM mouse model. (2005)
Journal Article
Van Valckenborgh, E., Mincher, D., Di Salvo, A., Van Riet, I., Young, L., Van Camp, B., & Vanderkerken, K. (2005). Targeting an MMP-9-activated prodrug to multiple myeloma diseased bone marrow: a proof of principle in the 5T33MM mouse model. Leukemia, 19, 1628-1633. https://doi.org/10.1038/sj.leu.2403866

Multiple myeloma (MM) is an incurable B-cell cancer characterised by the monoclonal proliferation of tumour cells in the bone marrow (BM). It has been described that matrix metalloproteinases (MMPs) and especially MMP-9 is secreted by MM cells. In th... Read More about Targeting an MMP-9-activated prodrug to multiple myeloma diseased bone marrow: a proof of principle in the 5T33MM mouse model..