Pelvic Chlamydial Infection Predisposes to Ectopic Pregnancy by Upregulating Integrin β1 to Promote Embryo-tubal Attachment (2018)
Journal Article
Ahmad, S. F., Brown, J. K., Campbell, L. L., Koscielniak, M., Oliver, C., Wheelhouse, N., Entrican, G., McFee, S., Wills, G. S., McClure, M. O., Horner, P. J., Gaikoumelou, S., Lee, K. F., Critchley, H. O., Duncan, W. C., & Horne, A. W. (2018). Pelvic Chlamydial Infection Predisposes to Ectopic Pregnancy by Upregulating Integrin β1 to Promote Embryo-tubal Attachment. EBioMedicine, 29, 159-165. https://doi.org/10.1016/j.ebiom.2018.02.020

Tubal ectopic pregnancies are a leading cause of global maternal morbidity and mortality. Previous infection with Chlamydia trachomatis is a major risk factor for tubal embryo implantation but the biological mechanism behind this association is uncle... Read More about Pelvic Chlamydial Infection Predisposes to Ectopic Pregnancy by Upregulating Integrin β1 to Promote Embryo-tubal Attachment.

Chlamydia trachomatis infection of human endometrial stromal cells induces defective decidualisation and chemokine release (2017)
Journal Article
Giakoumelou, S., Wheelhouse, N., Brown, J., Wade, J., Simitsidellis, I., Gibson, D., Saunders, P. T. K., Horner, P., Entrican, G., Howie, S. E. M., & Horne, A. W. (2017). Chlamydia trachomatis infection of human endometrial stromal cells induces defective decidualisation and chemokine release. Scientific Reports, 7(1), Article 2001. https://doi.org/10.1038/s41598-017-02223-z

Miscarriage affects ~20% of pregnancies and 30 maternal infections account for ~15% of early miscarriages. Chlamydia trachomatis (Ct) has been associated with miscarriage but the underlying mechanisms are unknown. Successful implantation requires end... Read More about Chlamydia trachomatis infection of human endometrial stromal cells induces defective decidualisation and chemokine release.

The role of infection in miscarriage (2015)
Journal Article
Giakoumelou, S., Wheelhouse, N., Cuschieri, K., Entrican, G., Howie, S. E., & Horne, A. W. (2016). The role of infection in miscarriage. Human Reproduction Update, 22(1), 116-133. https://doi.org/10.1093/humupd/dmv041

BACKGROUND: Miscarriage is the spontaneous loss of a pregnancy before 12 weeks (early miscarriage) or from 12 to 24 weeks (late miscarriage) of gestation. Miscarriage occurs in one in five pregnancies and can have considerable physiological and psych... Read More about The role of infection in miscarriage.

Chlamydia trachomatis infection increases fallopian tube PROKR2 via TLR2 and NFκB activation resulting in a microenvironment predisposed to ectopic pregnancy (2010)
Journal Article
Shaw, J. L. V., Wills, G. S., Lee, K.-F., Horner, P. J., McClure, M. O., Abrahams, V. M., Wheelhouse, N., Jabbour, H. N., Critchley, H. O. D., Entrican, G., & Horne, A. W. (2011). Chlamydia trachomatis infection increases fallopian tube PROKR2 via TLR2 and NFκB activation resulting in a microenvironment predisposed to ectopic pregnancy. American Journal of Pathology, 178(1), 253-260. https://doi.org/10.1016/j.ajpath.2010.11.019

Chlamydia trachomatis and smoking are major risk factors for tubal ectopic pregnancy (EP), but the underlying mechanisms of these associations are not completely understood. Fallopian tube (FT) from women with EP exhibit altered expression of prokine... Read More about Chlamydia trachomatis infection increases fallopian tube PROKR2 via TLR2 and NFκB activation resulting in a microenvironment predisposed to ectopic pregnancy.

Expression of the repulsive SLIT/ROBO pathway in the human endometrium and Fallopian tube (2010)
Journal Article
Duncan, W. C., McDonald, S. E., Dickinson, R. E., Shaw, J. L. V., Lourenco, P. C., Wheelhouse, N., Lee, K.-F., Critchley, H. O. D., & Horne, A. W. (2010). Expression of the repulsive SLIT/ROBO pathway in the human endometrium and Fallopian tube. Molecular Human Reproduction, 16, 950-959. https://doi.org/10.1093/molehr/gaq055

We investigated whether the repulsive SLIT/ROBO pathway is expressed in the endometrium and is negatively regulated during implantation. We also examined whether deficient expression in the Fallopian tube (FT) may predispose to ectopic pregnancy (EP)... Read More about Expression of the repulsive SLIT/ROBO pathway in the human endometrium and Fallopian tube.

Ovine trophoblast is a primary source of TNFalpha during Chlamydophila abortus infection. (2009)
Journal Article
Wheelhouse, N., Wattegedera, S., Stanton, J., Maley, S., Watson, D., Jepson, C., Deane, D., Buxton, D., Longbottom, D., Baszler, T., & Entrican, G. (2009). Ovine trophoblast is a primary source of TNFalpha during Chlamydophila abortus infection. Journal of Reproductive Immunology, 80(1-2), 49-56. https://doi.org/10.1016/j.jri.2008.12.003

Chlamydophila abortus is a Gram-negative obligate intracellular bacterium that causes infectious abortion in sheep (ovine enzootic abortion, OEA) and humans. Infected placentas recovered from sheep that experience OEA have thickened membranes, contai... Read More about Ovine trophoblast is a primary source of TNFalpha during Chlamydophila abortus infection..

Expression of secretory leukocyte protease inhibitor and elafin in human fallopian tube and in an in-vitro model of Chlamydia trachomatis infection (2008)
Journal Article
King, A. E., Wheelhouse, N., Cameron, S., McDonald, S. E., Lee, K.-F., Entrican, G., Critchley, H. O. D., & Horne, A. W. (2009). Expression of secretory leukocyte protease inhibitor and elafin in human fallopian tube and in an in-vitro model of Chlamydia trachomatis infection. Human Reproduction, 24(3), 679-686. https://doi.org/10.1093/humrep/den452

BACKGROUND: Secretory leukocyte protease inhibitor (SLPI) and elafin are anti-protease and anti-microbial molecules with a role in innate immune defence. They have been demonstrated at multiple mucosal surfaces including those of the female reproduct... Read More about Expression of secretory leukocyte protease inhibitor and elafin in human fallopian tube and in an in-vitro model of Chlamydia trachomatis infection.