Altered relationship between prefrontal glutamate and activation during cognitive control in people with high trait anxiety (2019)
Journal Article
Morgenroth, E., Orlov, N., Lythgoe, D. J., Stone, J. M., Barker, H., Munro, J., …Allen, P. (2019). Altered relationship between prefrontal glutamate and activation during cognitive control in people with high trait anxiety. Cortex, 117, 53-63. https://doi.org/10.1016/j.cortex.2019.02.021

Trait anxiety can affect cognitive control resulting in ineffective and/or inefficient task performance. Moreover, previous functional Magnetic Resonance Imaging (fMRI) studies have reported altered dorsolateral prefrontal cortex (DLPFC) activity in... Read More about Altered relationship between prefrontal glutamate and activation during cognitive control in people with high trait anxiety.

Is there a burden attached to synaesthesia? Health screening of synaesthetes in the general population (2018)
Journal Article
Carmichael, D. A., Smees, R., Shillcock, R. C., & Simner, J. (2019). Is there a burden attached to synaesthesia? Health screening of synaesthetes in the general population. British Journal of Psychology, 110(3), 530-548. https://doi.org/10.1111/bjop.12354

Synaesthesia has long been considered a benign alternative form of perception most often associated with positive rather than negative outcomes. The condition has been associated with a variety of cognitive and perceptual advantages, including benefi... Read More about Is there a burden attached to synaesthesia? Health screening of synaesthetes in the general population.

Silver nanoparticles promote the emergence of heterogeneic human neutrophil sub-populations (2018)
Journal Article
Kemp, S., Young, L., Ross, M., Prach, M., Hutchison, G. R., Malone, E., & Fraser, J. A. (2018). Silver nanoparticles promote the emergence of heterogeneic human neutrophil sub-populations. Scientific Reports, 8(1), Article 7506. https://doi.org/10.1038/s41598-018-25854-2

Neutrophil surveillance is central to nanoparticle clearance. Silver nanoparticles (AgNP) have numerous uses, however conflicting evidence exists as to their impact on neutrophils and whether they trigger damaging inflammation. Neutrophil’s importanc... Read More about Silver nanoparticles promote the emergence of heterogeneic human neutrophil sub-populations.

Power and research: a qualitative approach to understanding the relationship between major mental illness, masculinity and violence (2018)
Digital Artefact
Haddow, C. (2018). Power and research: a qualitative approach to understanding the relationship between major mental illness, masculinity and violence. [Sage Research Methods Case Study]

This case study reflects on research which explored the relationship between major mental illness and masculinity in the context of violent offending behavior. Studies which examine violence by the mentally disordered largely look to mental illness a... Read More about Power and research: a qualitative approach to understanding the relationship between major mental illness, masculinity and violence.

Direct Keap1-Nrf2 disruption as a potential therapeutic target for Alzheimer’s disease (2017)
Journal Article
Kerr, F., Sofola-Adesakin, O., Ivanov, D. K., Gatliff, J., Gomez Perez-Nievas, B., Bertrand, H. C., …Partridge, L. (2017). Direct Keap1-Nrf2 disruption as a potential therapeutic target for Alzheimer’s disease. PLoS Genetics, 13(3), https://doi.org/10.1371/journal.pgen.1006593

Nrf2, a transcriptional activator of cell protection genes, is an attractive therapeutic target for the prevention of neurodegenerative diseases, including Alzheimer’s disease (AD). Current Nrf2 activators, however, may exert toxicity and pathway ove... Read More about Direct Keap1-Nrf2 disruption as a potential therapeutic target for Alzheimer’s disease.

Chloride co-transporters as possible therapeutic targets for stroke (2016)
Journal Article
Martín-Aragón Baudel, M. A. S., Martín-Aragón Baudel, M. A. S., Poole, A. V., & Darlison, M. G. (2017). Chloride co-transporters as possible therapeutic targets for stroke. Journal of Neurochemistry, 140(2), 195-209. https://doi.org/10.1111/jnc.13901

Stroke is one of the major causes of death and disability worldwide. The major type of stroke is an ischaemic one, which is caused by a blockage that interrupts blood flow to the brain. There are currently very few pharmacological strategies to red... Read More about Chloride co-transporters as possible therapeutic targets for stroke.

Social responsiveness to inanimate entities: Altered white matter in a ‘social synaesthesia’ (2016)
Journal Article
Simner, J., Rehme, M., Carmichael, D., Bastin, M., Sprooten, E., McIntosh, A., …Zedler, M. (2016). Social responsiveness to inanimate entities: Altered white matter in a ‘social synaesthesia’. Neuropsychologia, 91, 282-289. https://doi.org/10.1016/j.neuropsychologia.2016.08.020

Judgments about personalities and social traits can be made by relatively brief exposure to animate living things. Here we show that unusual architecture in the microstructure of the human brain is related to atypical mental projections of personalit... Read More about Social responsiveness to inanimate entities: Altered white matter in a ‘social synaesthesia’.

Different dimensions of cognitive style in typical and atypical cognition: new evidence and a new measurement tool (2016)
Journal Article
Mealor, A. D., Simner, J., Rothen, N., Carmichael, D. A., & Ward, J. (2016). Different dimensions of cognitive style in typical and atypical cognition: new evidence and a new measurement tool. PLOS ONE, 11(5), https://doi.org/10.1371/journal.pone.0155483

We developed the Sussex Cognitive Styles Questionnaire (SCSQ) to investigate visual and verbal processing preferences and incorporate global/local processing orientations and systemising into a single, comprehensive measure. In Study 1 (N = 1542), fa... Read More about Different dimensions of cognitive style in typical and atypical cognition: new evidence and a new measurement tool.

Deletion of endogenous Tau proteins is not detrimental in Drosophila (2016)
Journal Article
Burnouf, S., Grönke, S., Augustin, H., Dols, J., Gorsky, M. K., Werner, J., …Partridge, L. (2016). Deletion of endogenous Tau proteins is not detrimental in Drosophila. Scientific Reports, 6, https://doi.org/10.1038/srep23102

Human Tau (hTau) is a highly soluble and natively unfolded protein that binds to microtubules within neurons. Its dysfunction and aggregation into insoluble paired helical filaments is involved in the pathogenesis of Alzheimer’s disease (AD), constit... Read More about Deletion of endogenous Tau proteins is not detrimental in Drosophila.

Cross-modal tactile–taste interactions in food evaluations (2015)
Journal Article
Slocombe, B., Carmichael, D., & Simner, J. (2016). Cross-modal tactile–taste interactions in food evaluations. Neuropsychologia, 88, 58-64. https://doi.org/10.1016/j.neuropsychologia.2015.07.011

Detecting the taste components within a flavoured substance relies on exposing chemoreceptors within the mouth to the chemical components of ingested food. In our paper, we show that the evaluation of taste components can also be influenced by the ta... Read More about Cross-modal tactile–taste interactions in food evaluations.

Do sequence-space synaesthetes have better spatial imagery skills? Yes, but there are individual differences (2015)
Journal Article
Havlik, A. M., Carmichael, D. A., & Simner, J. (2015). Do sequence-space synaesthetes have better spatial imagery skills? Yes, but there are individual differences. Cognitive Processing, 16(3), 245-253. https://doi.org/10.1007/s10339-015-0657-1

People with sequence-space synaesthesia perceive sequences (e.g. numbers, months, letters) as spatially extended forms. Here, we ask whether sequence-space synaesthetes have advantages in visuo-spatial skills such as mental rotation. Previous studies... Read More about Do sequence-space synaesthetes have better spatial imagery skills? Yes, but there are individual differences.

A Randomized Controlled Evaluation of the Efficacy of an Ankle-Foot Cast on Walking Recovery Early After Stroke: SWIFT Cast Trial (2015)
Journal Article
Pomeroy, V. M., Rowe, P., Clark, A., Walker, A., Kerr, A., Chandler, E., …Ugboule, U. C. (2016). A Randomized Controlled Evaluation of the Efficacy of an Ankle-Foot Cast on Walking Recovery Early After Stroke: SWIFT Cast Trial. Neurorehabilitation and Neural Repair, 30(1), 40-48. https://doi.org/10.1177/1545968315583724

Background. Timely provision of an ankle-foot orthosis (AFO) orthotist customized for individuals early after stroke can be problematic. Objective. To evaluate the efficacy of a therapist-made AFO (SWIFT Cast) for walking recovery. Methods. This w... Read More about A Randomized Controlled Evaluation of the Efficacy of an Ankle-Foot Cast on Walking Recovery Early After Stroke: SWIFT Cast Trial.

Is synaesthesia a dominantly female trait? (2015)
Journal Article
Simner, J., & Carmichael, D. A. (2015). Is synaesthesia a dominantly female trait?. Cognitive Neuroscience, 6(2-3), 68-76. https://doi.org/10.1080/17588928.2015.1019441

Synaesthesia is a familial condition that gives rise to unusual secondary percepts. We present a large-scale prevalence study which informs our ideas on whether the condition is more prevalent in men or women. A number of studies over the last 20 yea... Read More about Is synaesthesia a dominantly female trait?.

Validating a standardised test battery for synesthesia: Does the Synesthesia Battery reliably detect synesthesia? (2015)
Journal Article
Carmichael, D., Down, M., Shillcock, R., Eagleman, D., & Simner, J. (2015). Validating a standardised test battery for synesthesia: Does the Synesthesia Battery reliably detect synesthesia?. Consciousness and Cognition, 33, 375-385. https://doi.org/10.1016/j.concog.2015.02.001

Synesthesia is a neurological condition that gives rise to unusual secondary sensations (e.g., reading letters might trigger the experience of colour). Testing the consistency of these sensations over long time intervals is the behavioural gold stand... Read More about Validating a standardised test battery for synesthesia: Does the Synesthesia Battery reliably detect synesthesia?.

Creatine supplementation and exercise as possible therapeutic treatments in Parkinson’s Disease: A review (2014)
Journal Article
Graham, S. M., Baird, M., & Boyd, G. W. (2014). Creatine supplementation and exercise as possible therapeutic treatments in Parkinson’s Disease: A review. Archives of Exercise in Health and Disease, 4(3), 286-298. https://doi.org/10.5628/aehd.v4i3.169

Parkinson’s disease (PD) is the second most common progressive neurodegenerative condition after Alzheimer’s Disease. It is characterized by a progressive loss of dopaminergic neurons in the substantia nigra region of the brain. Symptoms and signs m... Read More about Creatine supplementation and exercise as possible therapeutic treatments in Parkinson’s Disease: A review.

Colour fluctuations in grapheme-colour synaesthesia: The effect of clinical and non-clinical mood changes (2014)
Journal Article
Kay, C. L., Carmichael, D. A., Ruffell, H. E., & Simner, J. (2015). Colour fluctuations in grapheme-colour synaesthesia: The effect of clinical and non-clinical mood changes. British Journal of Psychology, 106(3), 487-504. https://doi.org/10.1111/bjop.12102

Synaesthesia is a condition that gives rise to unusual secondary sensations (e.g., colours are perceived when listening to music). These unusual sensations tend to be reported as being stable throughout adulthood (e.g., Simner & Logie, 2007, Neurocas... Read More about Colour fluctuations in grapheme-colour synaesthesia: The effect of clinical and non-clinical mood changes.

Rates of white matter hyperintensities compatible with the radiological profile of multiple sclerosis within self-referred synesthete populations (2014)
Journal Article
Simner, J., Carmichael, D. A., Hubbard, E. M., Morris, Z., & Lawrie, S. M. (2015). Rates of white matter hyperintensities compatible with the radiological profile of multiple sclerosis within self-referred synesthete populations. Neurocase, 21(3), 322-330. https://doi.org/10.1080/13554794.2014.892625

Synesthesia is an inherited condition causing unusual secondary sensations (e.g, sounds might be experienced as both auditory and visual percepts). The condition has been linked with cognitive and perceptual benefits and is considered a benign altern... Read More about Rates of white matter hyperintensities compatible with the radiological profile of multiple sclerosis within self-referred synesthete populations.

Genetics and Inheritance of Synaesthesia (2013)
Book Chapter
Asher, J. E., & Carmichael, D. A. (2013). Genetics and Inheritance of Synaesthesia. In J. Simner, & E. M. Hubbard (Eds.), Oxford Handbook of Synesthesia (23-45). Oxford: Oxford University Press. https://doi.org/10.1093/oxfordhb/9780199603329.013.0002

Synaesthesia is a neurodevelopmental condition characterised by anomalous sensory perceptions and associated alterations in cognitive function. This chapter summarises what is known about the familial transmission of synaesthesia and its genetic unde... Read More about Genetics and Inheritance of Synaesthesia.

‘The Evil I Retreat from In Myself: Nationalism and das Ding’ (2013)
Book Chapter
Neill, C. (2013). ‘The Evil I Retreat from In Myself: Nationalism and das Ding’. In Nationalism and the Body Politic (209-222). London: Karnac Books

No abstract available.

GABAA receptor chloride channels are involved in the neuroprotective role of GABA following oxygen and glucose deprivation in the rat cerebral cortex but not in the hippocampus (2013)
Journal Article
Darlison, M. G., Dos-Anjos, S., Llorente, I. L., Llorente, I. L., Perez-Rodriguez, D., Martínez-Villayandre, B., …Fernández-López, A. (2013). GABAA receptor chloride channels are involved in the neuroprotective role of GABA following oxygen and glucose deprivation in the rat cerebral cortex but not in the hippocampus. Brain Research, 1533, 141-151. https://doi.org/10.1016/j.brainres.2013.08.024

Assays on "ex vivo" sections of rat hippocampus and rat cerebral cortex, subjected to oxygen and glucose deprivation (OGD) and a three-hour reperfusion-like (RL) recovery, were performed in the presence of either GABA or the GABA(A) receptor binding... Read More about GABAA receptor chloride channels are involved in the neuroprotective role of GABA following oxygen and glucose deprivation in the rat cerebral cortex but not in the hippocampus.