Assessing the toxicity of engineered nanomaterials in the male reproductive system: Developing an improved testing strategy for hazard assessment (2019)
Thesis
Ross, B. L. Assessing the toxicity of engineered nanomaterials in the male reproductive system: Developing an improved testing strategy for hazard assessment. (Thesis). Edinburgh Napier University. Retrieved from http://researchrepository.napier.ac.uk/Output/2404236

Reproduction is the only certain constant within animals and maintaining the integrity of this process is key to ensuring survival of the species. However, male fertility rates in the Western world are in decline and the use of assisted reproductive... Read More about Assessing the toxicity of engineered nanomaterials in the male reproductive system: Developing an improved testing strategy for hazard assessment.

The effect of azathioprine on bone health (2019)
Thesis
Morgan, S. The effect of azathioprine on bone health. (Thesis). Edinburgh Napier University. Retrieved from http://researchrepository.napier.ac.uk/Output/2386593

Individuals with inflammatory bowel disease (IBD) often present with poor bone health and have increased risk of osteoporotic bone fractures. The development of targeted therapies for this bone loss requires a better understanding of the underlying c... Read More about The effect of azathioprine on bone health.

The relationship between ICD-11 PTSD, complex PTSD and dissociative experiences (2019)
Journal Article
Hyland, P., Shevlin, M., Fyvie, C., Cloitre, M., & Karatzias, T. (2020). The relationship between ICD-11 PTSD, complex PTSD and dissociative experiences. Journal of Trauma and Dissociation, 21(1), 62-72. https://doi.org/10.1080/15299732.2019.1675113

Debate exists in the trauma literature regarding the role of dissociation in traumatic stress disorders. With the release of the new ICD-11 diagnostic guideline for posttraumatic stress disorder (PTSD) and complex PTSD (CPTSD), this issue warrants fu... Read More about The relationship between ICD-11 PTSD, complex PTSD and dissociative experiences.

Conditional deletion of E11/podoplanin in bone protects against load-induced osteoarthritis (2019)
Journal Article
Staines, K., Ikpegbu, E., Törnqvist, A., Dillon, S., Javaheri, B., Amin, A. K., …Farquharson, C. (2019). Conditional deletion of E11/podoplanin in bone protects against load-induced osteoarthritis. BMC Musculoskeletal Disorders, 20, Article 344 (2019). https://doi.org/10.1186/s12891-019-2731-9

Background: Subchondral bone (SCB) thickening is one of the earliest detectable changes in osteoarthritic joints and is considered a potential trigger for subsequent articular cartilage degeneration. In this manuscript, we examine whether disruption... Read More about Conditional deletion of E11/podoplanin in bone protects against load-induced osteoarthritis.

The Effects of Inflammatory Bowel Disease Drugs on the Autophagy Pathway (2019)
Thesis
Hooper, K. The Effects of Inflammatory Bowel Disease Drugs on the Autophagy Pathway. (Thesis). Edinburgh Napier University. Retrieved from http://researchrepository.napier.ac.uk/Output/2070992

Crohn’s disease (CD), one of the main forms of Inflammatory Bowel Disease (IBD), is a complex disorder characterised by chronic inflammation of the gastrointestinal (GI) tract. The aetiology of CD involves genetics and environmental factors that trig... Read More about The Effects of Inflammatory Bowel Disease Drugs on the Autophagy Pathway.

The role of the human cathelicidin LL-37 in rhinovirus infection (2019)
Thesis
Henderson Sousa, F. The role of the human cathelicidin LL-37 in rhinovirus infection. (Thesis). Edinburgh Napier University. Retrieved from http://researchrepository.napier.ac.uk/Output/2070903

Human rhinoviruses (HRVs) are the most common causes for symptomatic respiratory infections, and have been linked to severe respiratory conditions in children, and in immunocompromised and elderly individuals. Currently there are no specific treatmen... Read More about The role of the human cathelicidin LL-37 in rhinovirus infection.

Differentiating Symptom Profiles of ICD-11 PTSD, Complex PTSD and Borderline Personality Disorder: A Latent Class Analysis in a Multiply Traumatised Sample (2019)
Journal Article
Jowett, S., Karatzias, T., Shevlin, M., & Albert, I. (2020). Differentiating Symptom Profiles of ICD-11 PTSD, Complex PTSD and Borderline Personality Disorder: A Latent Class Analysis in a Multiply Traumatised Sample. Personality Disorders: Theory, Research, and Treatment, 11(1), 36-45. https://doi.org/10.1037/per0000346

Background: Complex PTSD (CPTSD) has been included as a diagnostic category in the ICD-11 consisting of six symptom clusters; the three PTSD criteria of Re-experiencing, Avoidance, and Hypervigilance, in addition to three Disturbances of Self-Organis... Read More about Differentiating Symptom Profiles of ICD-11 PTSD, Complex PTSD and Borderline Personality Disorder: A Latent Class Analysis in a Multiply Traumatised Sample.

The inflammatory bowel disease drug azathioprine induces autophagy via mTORC1 and the unfolded protein response sensor PERK (2019)
Journal Article
Hooper, K. M., Casanova, V., Kemp, S., Staines, K. A., Satsangi, J., Barlow, P. G., …Stevens, C. (2019). The inflammatory bowel disease drug azathioprine induces autophagy via mTORC1 and the unfolded protein response sensor PERK. Inflammatory Bowel Diseases, 25(9), 1481-1496. https://doi.org/10.1093/ibd/izz039

Background Genetic studies have strongly linked autophagy to Crohn's disease (CD) and stimulating autophagy in CD patients may be therapeutically beneficial. The aim of this study was to evaluate the effect of current inflammatory bowel disease (IBD)... Read More about The inflammatory bowel disease drug azathioprine induces autophagy via mTORC1 and the unfolded protein response sensor PERK.