Sertoli Cell Development and Function in an Animal Model of Testicular Dysgenesis Syndrome1 (2007)
Journal Article
Hutchison, G. R., Scott, H. M., Walker, M., McKinnell, C., Ferrara, D., Mahood, I. K., & Sharpe, R. M. (2008). Sertoli Cell Development and Function in an Animal Model of Testicular Dysgenesis Syndrome1. Biology of Reproduction, 78(2), 352-360. https://doi.org/10.1095/biolreprod.107.064006

Pregnancy exposure to di(n-butyl) phthalate (DBP) in rats induces a testicular dysgenesislike syndrome (TDS) in male offspring. Earlier studies suggested altered Sertoli cell development/maturation may result, especially in testes that become cryptor... Read More about Sertoli Cell Development and Function in an Animal Model of Testicular Dysgenesis Syndrome1.

The origins and time of appearance of focal testicular dysgenesis in an animal model of testicular dysgenesis syndrome: evidence for delayed testis development? (2007)
Journal Article
Hutchison, G. R., Sharpe, R. M., Mahood, I. K., Jobling, M., Walker, M., McKinnell, C., …Scott, H. M. (2008). The origins and time of appearance of focal testicular dysgenesis in an animal model of testicular dysgenesis syndrome: evidence for delayed testis development?. International Journal of Andrology, 31(2), 103-111. https://doi.org/10.1111/j.1365-2605.2007.00816.x

A testicular dysgenesis-like syndrome is induced in rats by fetal exposure todi(n-butyl) phthalate (DBP). A key feature of this is the formation of focal dys-genetic areas comprising malformed seminiferous cords⁄tubules and intratubu-lar Leydig cells... Read More about The origins and time of appearance of focal testicular dysgenesis in an animal model of testicular dysgenesis syndrome: evidence for delayed testis development?.

Role of androgens in fetal testis development and dysgenesis. (2007)
Journal Article
Scott, H. M., Hutchison, G. R., Mahood, I. K., Hallmark, N., Welsh, M., De Gendt, K., …Sharpe, R. M. (2007). Role of androgens in fetal testis development and dysgenesis. Endocrinology, 148, 2027-2036. doi:10.1210/en.2006-1622

This study sought to establish whether reduced androgen levels/action in the fetal rat testis induced by di(n-butyl) phthalate (DBP) contributes to dysgenetic features, namely reduced Sertoli cell number, occurrence of multinucleated gonocytes (MNG),... Read More about Role of androgens in fetal testis development and dysgenesis..