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Challenges and priorities for modelling livestock health and pathogens in the context of climate change (2016)
Journal Article
Özkan, Ş., Vitali, A., Lacetera, N., Amon, B., Bannink, A., Bartley, D. J., Blanco-Penedo, I., de Haas, Y., Dufrasne, I., Elliott, J., Eory, V., Fox, N. J., Garnsworthy, P. C., Gengler, N., Hammami, H., Kyriazakis, I., Leclère, D., Lessire, F., Macleod, M., Robinson, T. P., …Kipling, R. P. (2016). Challenges and priorities for modelling livestock health and pathogens in the context of climate change. Environmental Research, 151, 130-144. https://doi.org/10.1016/j.envres.2016.07.033

Climate change has the potential to impair livestock health, with consequences for animal welfare, productivity, greenhouse gas emissions, and human livelihoods and health. Modelling has an important role in assessing the impacts of climate change on... Read More about Challenges and priorities for modelling livestock health and pathogens in the context of climate change.

MAPK Activation Is Essential for Waddlia chondrophila Induced CXCL8 Expression in Human Epithelial Cells (2016)
Journal Article
Storrie, S., Longbottom, D., Barlow, P. G., & Wheelhouse, N. (2016). MAPK Activation Is Essential for Waddlia chondrophila Induced CXCL8 Expression in Human Epithelial Cells. PLOS ONE, 11(3), Article e0152193. https://doi.org/10.1371/journal.pone.0152193

Background
Waddlia chondrophila (W. chondrophila) is an emerging agent of respiratory and reproductive disease in humans and cattle. The organism is a member of the order Chlamydiales, and shares many similarities at the genome level and in growth s... Read More about MAPK Activation Is Essential for Waddlia chondrophila Induced CXCL8 Expression in Human Epithelial Cells.

Evidence of members of the Chlamydiales in bovine abortions in England and Wales (2015)
Journal Article
Wheelhouse, N., Mearns, R., Willoughby, K., Wright, E., Turnbull, D., & Longbottom, D. (2015). Evidence of members of the Chlamydiales in bovine abortions in England and Wales. Veterinary Record, 176, 465. https://doi.org/10.1136/vr.103075

Despite the economical importance and welfare issues associated with bovine abortion, as well as the potential zoonotic implications, the rate of diagnosis remains low with a cause of abortion only identified in around 22.5 per cent of submissions re... Read More about Evidence of members of the Chlamydiales in bovine abortions in England and Wales.

Chlamydia-related Organisms: Infection in Ruminants and Potential for Zoonotic transmission (2015)
Journal Article
Wheelhouse, N., & Longbottom, D. (2015). Chlamydia-related Organisms: Infection in Ruminants and Potential for Zoonotic transmission. Current Clinical Microbiology Reports, 2(1), 1-9. https://doi.org/10.1007/s40588-014-0011-x

The chlamydiae are a diverse group of obligate intracellular Gram-negative bacteria that are known to infect a wide variety of host species and are responsible for a wide range of diseases in animals and man. Studies of human disease first provided e... Read More about Chlamydia-related Organisms: Infection in Ruminants and Potential for Zoonotic transmission.

An unusual presentation of Chlamydia pneumoniaeinfection in a Royal Python (Python regius) (2014)
Journal Article
Cope, I., Wheelhouse, N., Pocknell, A., Dagleish, M., & Summers, B. (2014). An unusual presentation of Chlamydia pneumoniaeinfection in a Royal Python (Python regius). Veterinary record case reports, 2(1), Article e000086. https://doi.org/10.1136/vetreccr-2014-000086

Chlamydia species are a relatively newly recognised and emerging pathogen in reptile species. Chlamydia pneumoniae has been reported to cause infections in several snake species, as well as other reptiles and amphibia, leading to granulomatous lesion... Read More about An unusual presentation of Chlamydia pneumoniaeinfection in a Royal Python (Python regius).

Chlamydia in cases of bovine abortion in Ireland (2014)
Journal Article
Wheelhouse, N., Longbottom, D., & O'Donovan, J. (2014). Chlamydia in cases of bovine abortion in Ireland. Veterinary Record, 174(22), 560-561. https://doi.org/10.1136/vr.g3567

We report the findings of a preliminary investigation into chlamydial involvement in cases of bovine abortion in Ireland. Chlamydia abortus has long been recognised as a known major cause of ruminant abortion. However, several newly recognised specie... Read More about Chlamydia in cases of bovine abortion in Ireland.

Risk factors associated with Lawsonia intracellularis in English pig farms (2013)
Journal Article
Bae, J. K., Wieland, B., Sait, M., Longbottom, D., Smith, D. G. E., Alarcon, P., & Wheelhouse, N. (2013). Risk factors associated with Lawsonia intracellularis in English pig farms. Veterinary Journal, 197(3), 707-711. https://doi.org/10.1016/j.tvjl.2013.03.020

Porcine proliferative enteropathy (PPE) caused by the bacterium Lawsonia intracellularis causes considerable economic loss to the pig industry. The objective of this study was to evaluate the seroprevalence of L. intracellularis exposure in different... Read More about Risk factors associated with Lawsonia intracellularis in English pig farms.

Genome Sequence of Lawsonia intracellularis Strain N343, Isolated from a Sow with Hemorrhagic Proliferative Enteropathy (2013)
Journal Article
Sait, M., Aitchison, K., Wheelhouse, N., Wilson, K., Alex Lainson, F., Longbottom, D., & Smith, D. G. E. (2013). Genome Sequence of Lawsonia intracellularis Strain N343, Isolated from a Sow with Hemorrhagic Proliferative Enteropathy. Genome Announcements, 1(1), https://doi.org/10.1128/genomeA.00027-13

Lawsonia intracellularis is the etiological agent of proliferative enteropathy (PE), causing mild or acute hemorrhagic diarrhea in infected animals. Here we report the genome sequence of strain N343, isolated from a sow that died of hemorrhagic PE. N... Read More about Genome Sequence of Lawsonia intracellularis Strain N343, Isolated from a Sow with Hemorrhagic Proliferative Enteropathy.

Expression patterns of five polymorphic membrane proteins during the Chlamydia abortus developmental cycle (2012)
Journal Article
Longbottom, D., Wheelhouse, N., Sait, M., Wilson, K., Aitchison, K., McLean, K., & Smith, D. G. E. (2012). Expression patterns of five polymorphic membrane proteins during the Chlamydia abortus developmental cycle. Veterinary Microbiology, 160(3-4), 525-529. https://doi.org/10.1016/j.vetmic.2012.06.017

It has been suggested that polymorphic membrane proteins (Pmps) belonging to the Type V autotransporter protein family play an important role in the pathogenesis of Chlamydia abortus (C. abortus; formerly Chlamydophila abortus) infection. In a previo... Read More about Expression patterns of five polymorphic membrane proteins during the Chlamydia abortus developmental cycle.

Processing of Chlamydia abortus polymorphic membrane protein 18D during the chlamydial developmental cycle (2012)
Journal Article
Wheelhouse, N. M., Sait, M., Aitchison, K., Livingstone, M., Wright, F., McLean, K., Inglis, N. F., Smith, D. G. E., & Longbottom, D. (2012). Processing of Chlamydia abortus polymorphic membrane protein 18D during the chlamydial developmental cycle. PLOS ONE, 7, Article e49190. https://doi.org/10.1371/journal.pone.0049190

BACKGROUND: Chlamydia possess a unique family of autotransporter proteins known as the Polymorphic membrane proteins (Pmps). While the total number of pmp genes varies between Chlamydia species, all encode a single pmpD gene. In both Chlamydia tracho... Read More about Processing of Chlamydia abortus polymorphic membrane protein 18D during the chlamydial developmental cycle.

Evaluation of the impact and control of enzootic abortion of ewes (2012)
Journal Article
Longbottom, D., Entrican, G., Wheelhouse, N., Brough, H., & Milne, C. (2013). Evaluation of the impact and control of enzootic abortion of ewes. Veterinary Journal, 195(2), 257-259. https://doi.org/10.1016/j.tvjl.2012.06.018

Despite the availability of effective management and treatment strategies, Chlamydia abortus remains the single most frequently diagnosed cause of infectious ovine abortion (enzootic abortion of ewes, EAE) in the UK and one of the most significant ca... Read More about Evaluation of the impact and control of enzootic abortion of ewes.

Involvement of Parachlamydia in bovine abortions in Scotland (2012)
Journal Article
Howie, F., Gidlow, J., Greub, G., Wheelhouse, N., Dagleish, M., & Longbottom, D. (2012). Involvement of Parachlamydia in bovine abortions in Scotland. Veterinary Journal, 193(2), 586-588. https://doi.org/10.1016/j.tvjl.2012.01.008

Bovine abortion represents a major animal welfare issue and a cause of substantial economic loss yet the rate of successful diagnosis remains low. Chlamydia-related organisms including Parachlamydia have recently emerged as putative cattle abortifaci... Read More about Involvement of Parachlamydia in bovine abortions in Scotland.

New challenges for vaccination to prevent chlamydial abortion in sheep (2011)
Journal Article
Entrican, G., Wheelhouse, N., Wattegedera, S. R., & Longbottom, D. (2012). New challenges for vaccination to prevent chlamydial abortion in sheep. Comparative Immunology, Microbiology and Infectious Diseases, 35(3), 271-276. https://doi.org/10.1016/j.cimid.2011.12.001

Ovine enzootic abortion (OEA) is caused by the obligate intracellular Gram-negative bacterium Chlamydia abortus. OEA remains a common cause of infectious abortion in many sheep-rearing countries despite the existence of commercially available vaccine... Read More about New challenges for vaccination to prevent chlamydial abortion in sheep.

Genetic variability of Chlamydophila abortus strains assessed by PCR-RFLP analysis of polymorphic membrane protein-encoding genes (2011)
Journal Article
Saita, M., Clarka, E. M., Wheelhouse, N., Spalding, L., Livingstone, M., Sachse, K., Markey, B. K., Magnino, S., Siarkou, V. I., Vretou, E., Caro, M. R., Yaga, R., Lainson, F. A., Smith, D. G. E., Wright, F., & Longbottom, D. (2011). Genetic variability of Chlamydophila abortus strains assessed by PCR-RFLP analysis of polymorphic membrane protein-encoding genes. Veterinary Microbiology, 151(3-4), 284-290. https://doi.org/10.1016/j.vetmic.2011.03.005

This study used PCR-RFLP to investigate the genetic variability of pmp-encoding genes from fifty-two Chlamydophila abortus (C. abortus) strains originating from abortion cases from various geographical regions and host species. Six primer pairs were... Read More about Genetic variability of Chlamydophila abortus strains assessed by PCR-RFLP analysis of polymorphic membrane protein-encoding genes.

Ectopic lymphoid tissue formation in the lungs of mice infected with Chlamydia pneumoniae is associated with epithelial macrophage inflammatory protein-2/CXCL2 expression (2010)
Journal Article
Fitch, P., Wheelhouse, N., Bowles, P., Paterson, M., Longbottom, D., Entrican, G., & Howie, S. (2010). Ectopic lymphoid tissue formation in the lungs of mice infected with Chlamydia pneumoniae is associated with epithelial macrophage inflammatory protein-2/CXCL2 expression. Clinical and Experimental Immunology, 162(2), 372-378. https://doi.org/10.1111/j.1365-2249.2010.04231.x

Infection with Chlamydia pneumoniae (Cp) accounts for around 10% of community acquired bacterial pneumonia and has been associated with other chronic inflammatory conditions. We describe a C57/Bl6 murine model of Cp lung infection characterized by a... Read More about Ectopic lymphoid tissue formation in the lungs of mice infected with Chlamydia pneumoniae is associated with epithelial macrophage inflammatory protein-2/CXCL2 expression.

Immunological paradigms and the pathogenesis of ovine chlamydial abortion (2010)
Journal Article
Entrican, G., Wattegedera, S., Wheelhouse, N., Allan, A., & Rocchi, M. (2010). Immunological paradigms and the pathogenesis of ovine chlamydial abortion. American Journal of Reproductive Immunology, 64(4), 287-294. https://doi.org/10.1111/j.1600-0897.2010.00907.x

Successful mammalian pregnancy involves complex immunological interactions between the mother and foetus that are not yet fully understood. A number of immunological paradigms have been established to explain the failure of the maternal immune system... Read More about Immunological paradigms and the pathogenesis of ovine chlamydial abortion.

Evidence of Chlamydophila abortus vaccine strain 1B as a possible cause of ovine enzootic abortion (2010)
Journal Article
Wheelhouse, N., Aitchison, K., Laroucau, K., Thomson, J., & Longbottom, D. (2010). Evidence of Chlamydophila abortus vaccine strain 1B as a possible cause of ovine enzootic abortion. Vaccine, 28(35), 5657-5663. https://doi.org/10.1016/j.vaccine.2010.04.114

Chlamydophila abortus, the agent of ovine enzootic abortion (OEA), is a major cause of lamb mortality worldwide. Disease can be controlled through the use of vaccines based on the 1B temperature-sensitive mutant strain of C. abortus. This study inves... Read More about Evidence of Chlamydophila abortus vaccine strain 1B as a possible cause of ovine enzootic abortion.